Sr. Principal Instrument Replacement Lead
Waters Corporation
Overview Overview Our Enterprise Transformation team is on a mission to improve business outcomes and employee experiences by driving step-change improvements in critical enterprise processes, and the technology and analytics supporting these. As a Sr. Principal, Lifecycle Program Lead, you will be responsible for delivering transformative improvements in enterprise Instrument Replacement capabilities, defining and scaling a consistent, data driven approach to managing instrument lifecycle replacement across business units, regions, and commercial motions. This role is accountable for end‑to‑end replacement excellence, supporting the commercial teams with installed base intelligence, replacement strategy and playbooks to improve commercial execution, governance model, and value realization. Partnering with global sales leadership, commercial excellence, finance, IT, and operations, the desired business outcomes include translating lifecycle strategy into repeatable operating models that improve revenue retention, revenue growth and customer loyalty. Responsibilities Enterprise Instrument Replacement strategy Collaborate with commercial leadership and functional SMEs in the definition of the enterprise instrument replacement strategy, ensuring a consistent, scalable approach across regions, product lines, and customer segments End‑to‑End Lifecycle model design Collaborate with commercial leadership and functional SMEs to design and support governing the future‑state replacement operating models, including: Installed base intelligence and lifecycle triggers; Commercial plays and GTM motions; Pricing guidance. Ensure replacement programs are simple to understand, easy to deploy, and measurable, enabling effective adoption by business units Cross‑Functional Leadership & Governance Lead cross‑functional collaboration across Sales, Service, Commercial Excellence, Sales, Service, Product Management, Finance, IT, and Analytics; Facilitate executive alignment and decision making by clearly articulating trade‑offs, value cases, and risks; Define success metrics, KPIs, and partner with stakeholders to support governance and operating cadence for instrument replacement excellence Digital, Data & Analytics Enablement Partner with the Commercial Operations and Customer 360 teams to ensure accurate and actionable installed base visibility; Embed lifecycle and replacement triggers into CRM and analytics platforms; Enable consistent tracking of replacement opportunities, conversion, and value realization Value Realization & Continuous Improvement Define and track enterprise‑level impact of instrument replacement initiatives on revenue retention and growth, margin and asset productivity, and customer experience and loyalty; Identify systemic bottlenecks and improvement opportunities, partnering with business units to address them; Scale best practices globally while enabling regional and segment‑specific execution flexibility Qualifications Bachelor’s degree in business, Engineering, Economics, or a related field 12+ years of experience in lifecycle management, commercial excellence, sales operations, service operations, or enterprise transformation Proven experience leading complex, cross‑functional programs in a global, multi‑BU environment Strong understanding of: Installed base management and asset lifecycle concepts; Commercial motions supporting replacement, upgrades, and renewals; Sales and service operating models Experience working with CRM, installed base, and analytics platforms (e.g., Salesforce or similar) Demonstrated ability to influence without authority and drive alignment across senior stakeholders Strong analytical mindset with the ability to translate strategy into execution Lean / continuous improvement experience a plus Results‑oriented, with a strong sense of ownership and urgency Company Description Waters Corporation (NYSE:WAT) is a global leader in life sciences and diagnostics, dedicated to accelerating the benefits of pioneering science through analytical technologies, informatics, and service. With a focus on regulated, high-volume testing environments, our innovative portfolio harnesses deep scientific expertise across chemistry, physics, and biology. We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance. Through a shared culture of relentless innovation, our passionate team of ~16,000 colleagues turn scientific challenges into breakthroughs that improve lives worldwide. Diversity and inclusion are fundamental to our core values at Waters Corporation. It benefits our employees, our products, our customers and our community. Waters complies with all applicable federal, state, and local laws. Qualified applicants are considered without regard to sex, race, color, ancestry, national origin, citizenship status, religion, age, marital status (including civil unions), military service, veteran status, pregnancy (including childbirth and related medical conditions), genetic information, sexual orientation, gender identity, legally recognized disability, domestic violence victim status, or any other characteristic protected by law. Waters is proud to be an equal opportunity workplace and is an affirmative action employer. All hiring decisions are based solely on qualifications, merit, and business needs at the time. Key Words
- Instrument replacement
- instrument placement
- Waters Corporation is seeking a Sr. Principal, Lifecycle Program Lead in Milpitas, California. This role involves driving transformative improvements in instrument replacement processes across business units. You'll collaborate with sales and operational teams, lead cross...Senior
$132.4k - $251.6k
...solving the world’s most complex problems. With our three market leading businesses, world-class operations and investments in research... ...and defense.Applied Signal Technology (AST) is seeking an Sr Principal Systems Engineer / ICT Lead who strives for excellence and has...PrincipalSeniorTemporary workWork experience placementWork at officeRemote workFlexible hours- ...offering product solutions in the automotive, industrial, infrastructure and IoT markets. Our robust product portfolio includes world leading MCUs, SoCs, Analog and power products, plus Winning Combination solutions that curate these complementary products. We are a key...PrincipalSeniorWorldwideNight shift
$178.14k - $320.51k
As the Senior Principal Lead of Product Marketing Management for Vehicle Electrification, you will be the primary architect of our semiconductor product roadmap for the rapidly evolving Electric Vehicle (EV) market. You will lead the strategy for Integrated Circuit (IC...PrincipalSeniorLocal area$180.64k - $261.58k
...dynamic, collaborative environment and are ready to shape the future of power management, we'd love to hear from you!Key Responsibilities:Lead project: own top-level design and verification, partition blocks. Drive design flow to keep project on schedule and error...PrincipalPermanent employmentFull timeWork at officeDay shift- PsiQuantum is seeking a Principal Optical Fiber Architect to lead the design and integration of the Optical Distribution Network for quantum systems. This role involves developing the fiber network while ensuring performance and reliability across components. Applicants...Principal
- BD is looking for a Marketing Product Manager for Research Instruments in the US region. This strategic role oversees commercial performance, go-to-market strategies, and revenue growth for Research Instruments. The successful candidate will work alongside sales leadership...
- A leader in fusion technology located in California seeks a Principal Mechanical Engineer to drive R&D equipment design. This role involves leading design projects and mentoring a team in a fast-paced environment. The ideal candidate has substantial experience in mechanical...Principal
- ...Description Job Description Job Description Job title: Senior Principal Applications Engineer Experience: 5-14 Years Location:... ...: Full-time Must Haves: Experience in analytical instrumentation e.g. Mass spectrometers and gas analyzers. Familiarity...PrincipalSeniorFull timeWork experience placement
$150k - $250k
DescriptionOverview :Responsible for design, development, and refinement of Multi-Gbps PAM4 SerDes IP. Design and debug experience on RTL level signal synchronization, clock tree and cross domain clock designs is a significant plus.Need to work closely with system and test...PrincipalSenior- About The Role We are seeking an experienced Senior Teleoperations Lead to oversee robotics operations teams supporting AI training,... ...information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans...SeniorShift work
$175k - $250k
...to join the Extreme team.JOB DESCRIPTION Sr. Principal Engineer/ Principal Engineer - Cloud... ...exceptional Sr. Principal/Principal Engineer to lead the design, architecture, and... ...assist our recruitment team but do not replace human judgment. Final hiring decisions are...PrincipalSeniorFull timeLocal areaWork from home- ...qualification, and reliability initiatives. The role ensures measurement accuracy, regulatory compliance, and asset performance by leading complex calibrations and data-driven improvements. You will mentor staff, lead audits, and collaborate with Quality, R&D, Manufacturing...Senior
$220k - $240k
...solutions that protect and empower the world’s leading brands, Fortune 500 companies and... ...For more information, please visit As Sr. Principal Technical Program Manager, you will be a... ...assist our recruitment team but do not replace human judgment. Final hiring decisions...PrincipalSenior- ...Job Description Job Description Sr./Lead Linux Systems Administrator We are seeking an experienced Linux System Administrator who can provide solutions and be able to work independently and a good team player. Responsibilities: Responsible for administering...SeniorRemote work
$154k - $286k
...Cadence global silicon solutions teams who are designing semiconductor IP for the top electronic product companies in the world, in leading edge semiconductor processes, using the latest industry tools and methodologies. As a Technical Quality Engineer and member of the...PrincipalSeniorFull time$232k - $368k
...is possible.NVIDIA’s Silicon Co-Design Group is hiring a Chip Lead to serve as the technical lead for one of our most consequential... ...the crowd:Prior experience as a Chip Lead, Project Tech Lead, or Principal or Distinguished Engineer on a flagship GPU, AI accelerator,...PrincipalFull time- ...create a brighter, more sustainable future while tackling the most pressing challenges of the 21st century.We are looking for a Sr. Principal Electrical Engineer, Microgrid Modeling to join our team in one of today’s most exciting technologies. This role will report to...PrincipalSeniorFull timeWork at officeWorldwide
$231.1k - $358.2k
...purpose-built, software centric Physical AI HW/SW platform that leads the industry in Ease of use, performance, and power efficiency... ...and more. For more information, visit . We're looking for a Sr. Principal-level DFT leader to own that foundation. This isn't a role focused...PrincipalSeniorFull timeWork at office- A leading technology company in Mountain View is looking for an experienced AI Science Lead. You will lead a team to develop cutting-edge machine learning models that enhance customer experiences. The ideal candidate will hold a PhD/MS and possess strong skills in statistics...Principal
- ...expertise extends beyond the hardware realm, encrompassing 3P enablement, where we develop custom AI Software Solutions for Industry leading AI customers. Are you excited to work with one of Top 1% of the AI companies in the world? THE ROLE: Would you like to be part of a...PrincipalSenior
- ...most pressing challenges of the 21st century.We are looking for a Sr Principal Engineer, Enclosures Design, to join our team in one of today’s... ...real world deployment for decades.Role and Responsibilities: Lead development and integration of next generation enclosures...PrincipalSeniorFull timeWork at officeWorldwide
$119.8k - $234.7k
...advertiser success, and we are hiring for Senior or Principal Product Managers.Diagnostics: In this role, you will lead the next generation of Diagnostics Experiences... ...engage and act efficiently, and use instrumentation and experimentation to continuously improve.Customer...PrincipalSeniorOngoing contractTemporary workLocal area- Hewlett Packard Enterprise Labs seeks a Principal AI Research Scientist for the HPE Quantum team within Emergent Machine Intelligence. This senior role focuses on original, publication-driven research at the intersection of AI, quantum computing, and physical science. The...Principal
$214.67k - $322k
...ultimately contribute to every individual's freedom. OKX is a leading crypto exchange, and the developer of OKX Wallet, giving millions... ...for new product ideas. Identify, define, implement and instrument market research, product design, product implementation and product...PrincipalSeniorLocal area$129.3k - $193.9k
...not only part of history, they're making history.Northrop Grumman Mission Systems (NGMS) is looking for you to join our team as a Sr. Principal Manufacturing Engineer based out of Sunnyvale, CA. You will support the manufacturing and testing of marine launcher systems,...PrincipalSeniorFull timeWork experience placementRelocation packageShift workWeekend work$200k - $266.4k
...Job Description Job Description Job Title:Senior Principal Engineer, Hardware Application Engineering — Board & System Design... ...next-generation 448G systems and open AI fabric standards. Lead hardware bring-up support, root-cause debug, and issue resolution...PrincipalSeniorFull timeVisa sponsorshipRelocation package- ...the kind of precision that drives great outcomes.Job SummaryAs a Sr Principal Product Manager for Strata Cloud Manager Platform, you will be... ...to present our solutions, articulate requirements, and will lead a focused product team to deliver on our vision and strategy.Key...PrincipalSeniorFull timeWork at office
$129.3k - $193.9k
...life and launch your career today.Northrop Grumman is seeking a Sr. Principal Systems Engineer Level 4 to join our team of qualified,... ...Interface Control Documents, Arrangement Drawings, etc.Participate/Lead and coordinate preparation, conduct and closeout for internal...PrincipalSeniorFull timeWork experience placementRelocation packageShift work- Google is seeking a Strategic Partner Development Principal Lead, RCS for Business, onsite in Mountain View, CA. You will manage a portfolio of business customers, translate their needs into compelling advertising solutions, and drive extraordinary outcomes for Google...PrincipalTemporary work
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Sr. Principal Instrument Replacement Lead. Be the first to apply!
- senior network engineer remote Milpitas, CA
- senior app developer Milpitas, CA
- senior manager legal Milpitas, CA
- sr project manager Milpitas, CA
- senior staff systems engineer Milpitas, CA
- senior commercial counsel Milpitas, CA
- senior manager tax Milpitas, CA
- senior infrastructure engineer Milpitas, CA
- senior living Milpitas, CA
- senior implementation project manager Milpitas, CA


