Sr. Principal Instrument Replacement Lead
Waters Corporation
Overview Overview Our Enterprise Transformation team is on a mission to improve business outcomes and employee experiences by driving step-change improvements in critical enterprise processes, and the technology and analytics supporting these. As a Sr. Principal, Lifecycle Program Lead, you will be responsible for delivering transformative improvements in enterprise Instrument Replacement capabilities, defining and scaling a consistent, data driven approach to managing instrument lifecycle replacement across business units, regions, and commercial motions. This role is accountable for end‑to‑end replacement excellence, supporting the commercial teams with installed base intelligence, replacement strategy and playbooks to improve commercial execution, governance model, and value realization. Partnering with global sales leadership, commercial excellence, finance, IT, and operations, the desired business outcomes include translating lifecycle strategy into repeatable operating models that improve revenue retention, revenue growth and customer loyalty. Responsibilities Enterprise Instrument Replacement strategy Collaborate with commercial leadership and functional SMEs in the definition of the enterprise instrument replacement strategy, ensuring a consistent, scalable approach across regions, product lines, and customer segments End‑to‑End Lifecycle model design Collaborate with commercial leadership and functional SMEs to design and support governing the future‑state replacement operating models, including: Installed base intelligence and lifecycle triggers; Commercial plays and GTM motions; Pricing guidance. Ensure replacement programs are simple to understand, easy to deploy, and measurable, enabling effective adoption by business units Cross‑Functional Leadership & Governance Lead cross‑functional collaboration across Sales, Service, Commercial Excellence, Sales, Service, Product Management, Finance, IT, and Analytics; Facilitate executive alignment and decision making by clearly articulating trade‑offs, value cases, and risks; Define success metrics, KPIs, and partner with stakeholders to support governance and operating cadence for instrument replacement excellence Digital, Data & Analytics Enablement Partner with the Commercial Operations and Customer 360 teams to ensure accurate and actionable installed base visibility; Embed lifecycle and replacement triggers into CRM and analytics platforms; Enable consistent tracking of replacement opportunities, conversion, and value realization Value Realization & Continuous Improvement Define and track enterprise‑level impact of instrument replacement initiatives on revenue retention and growth, margin and asset productivity, and customer experience and loyalty; Identify systemic bottlenecks and improvement opportunities, partnering with business units to address them; Scale best practices globally while enabling regional and segment‑specific execution flexibility Qualifications Bachelor’s degree in business, Engineering, Economics, or a related field 12+ years of experience in lifecycle management, commercial excellence, sales operations, service operations, or enterprise transformation Proven experience leading complex, cross‑functional programs in a global, multi‑BU environment Strong understanding of: Installed base management and asset lifecycle concepts; Commercial motions supporting replacement, upgrades, and renewals; Sales and service operating models Experience working with CRM, installed base, and analytics platforms (e.g., Salesforce or similar) Demonstrated ability to influence without authority and drive alignment across senior stakeholders Strong analytical mindset with the ability to translate strategy into execution Lean / continuous improvement experience a plus Results‑oriented, with a strong sense of ownership and urgency Company Description Waters Corporation (NYSE:WAT) is a global leader in life sciences and diagnostics, dedicated to accelerating the benefits of pioneering science through analytical technologies, informatics, and service. With a focus on regulated, high-volume testing environments, our innovative portfolio harnesses deep scientific expertise across chemistry, physics, and biology. We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance. Through a shared culture of relentless innovation, our passionate team of ~16,000 colleagues turn scientific challenges into breakthroughs that improve lives worldwide. Diversity and inclusion are fundamental to our core values at Waters Corporation. It benefits our employees, our products, our customers and our community. Waters complies with all applicable federal, state, and local laws. Qualified applicants are considered without regard to sex, race, color, ancestry, national origin, citizenship status, religion, age, marital status (including civil unions), military service, veteran status, pregnancy (including childbirth and related medical conditions), genetic information, sexual orientation, gender identity, legally recognized disability, domestic violence victim status, or any other characteristic protected by law. Waters is proud to be an equal opportunity workplace and is an affirmative action employer. All hiring decisions are based solely on qualifications, merit, and business needs at the time. Key Words
- Instrument replacement
- instrument placement
- Waters Corporation is seeking a Sr. Principal, Lifecycle Program Lead in Milpitas, California. This role involves driving transformative improvements in instrument replacement processes across business units. You'll collaborate with sales and operational teams, lead cross...Senior
- ...enable customers to deploy intelligent, reliable, and scalable robotic systems across industries. Role Overview As Principal Robotics SLAM and Positioning Lead, you will be the technical owner and architect for Qualcomm’s core localization and mapping services. You will...PrincipalSeniorLocal areaWork from home
- ...Becton Dickinson is seeking a Senior Marketing Manager for Instruments & Informatics in Milpitas, California. This strategic role focuses on driving demand, adoption, and revenue through integrated marketing programs. The ideal candidate will have extensive B2B marketing...Senior
- ...Title: Principal / Lead Wireless Communications System Architect Location: US, Europe Job Type: Full-Time / Consultant Industry... .... These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by...PrincipalFull time
- Job Summary T he AI Interconnect Architect designs and engineers high-speed networking and communication systems for AI inference infrastructure, including servers, racks, and chips. This role focuses on delivering bandwidth, power efficiency, scalability, and optimized...PrincipalSenior
- ...Principal Mechanical Engineer - Instruments It started with a simple idea: what if surgery could be less invasive... ...uses highly complex mechanics, replaceable instruments and accessories, and... ...requirements for medical devices. Lead by having a breadth of technical knowledge...PrincipalWorldwide
$178.14k - $320.51k
...Job Description As the Senior Principal Lead of Product Marketing Management for Vehicle Electrification, you will be the primary architect of our semiconductor product roadmap for the rapidly evolving Electric Vehicle (EV) market. You will lead the strategy for...PrincipalSeniorLocal area$150k - $225k
A leading fusion energy company in Milpitas seeks a Principal Mechanical Engineer to lead R&D and equipment design for advanced thermal vacuum deposition systems. The ideal candidate will have over 15 years of experience, a Master’s in Mechanical Engineering, and skills...PrincipalFlexible hours- BD is looking for a Marketing Product Manager for Research Instruments in the US region. This strategic role oversees commercial performance, go-to-market strategies, and revenue growth for Research Instruments. The successful candidate will work alongside sales leadership...
$243k - $328.5k
...decisions that need their expertise. We need a Principal who can scale this across the company... ...Architect, the Telemetry and Insights Lead, and senior operating leaders across... ...to stick. Set baselines before launch. Instrument the pre-state with the Telemetry and Insights...Principal- A leading biotech firm is seeking a Principal Mechanical Engineer III in Santa Clara, CA. The candidate will lead the design and development of next-generation DNA sequencing instrumentation, focusing on complex mechanical challenges. Requirements include a PhD or advanced...Principal
$197.6k - $261.3k
...Gen Digital Inc. is looking for a Senior Principal Product Manager to lead the ecosystem strategy in Mountain View, California. The ideal candidate will own the strategy to protect and grow the business through innovative partnerships and incorporate emerging technologies...PrincipalSenior$195k - $220k
...and software needed to make these systems commercially valuable. Our application, software, and industry teams work directly with leading Fortune 500 companies-including Lockheed Martin, Mercedes-Benz, Boehringer Ingelheim, and Mitsubishi Chemical-to prepare quantum solutions...PrincipalFull timeShift work$260k - $275k
...SENIOR PRINCIPAL SOFTWARE ENGINEER Saviynt is an identity platform built to power and... ...to build out AI security for the world's leading enterprises. In a world of... ...assist our recruitment team but do not replace human judgment. Final hiring decisions are...PrincipalSenior- ...Dormont Manufacturing Co is seeking a Sr. Principal Architect to lead the technical direction of the Adobe Intelligence Platform. The ideal candidate will bring over 15 years of software engineering experience and deep expertise in AI architectures. This position involves...PrincipalSenior
$220k - $240k
...security, with solutions that protect and empower the world's leading brands, Fortune 500 companies and government institutions. For... ...information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans...PrincipalSeniorWork experience placementRemote work$170k - $277k
...Summary We are seeking a Senior or Principal Backend Engineer for our Santa Clara Headquarters... ...Browser. In this role, you will be instrumental in developing a key security solution... ...security policies. You will take a leading position within the team, owning and leading...PrincipalSeniorFull timeWork at office- ...Johnson & Johnson in Santa Clara, CA is seeking a Principal AI Lead to drive the development of AI models for surgical applications. This role focuses on developing and deploying intelligent solutions that streamline surgical workflows and improve patient outcomes. The...Principal
- Do you have a strong background in Component Engineering? Join our HiRel team and leverage your experience to support the business with designing, developing, modifying and evaluating analog, power and mixed signal electronic parts, components or integrated circuitry for...PrincipalSenior
- ...The National Association of Secondary School Principals seeks a Principal for a middle school in Milpitas, California. This position serves as the educational and community leader, overseeing all school objectives, instructional programs, and staff assignments. Qualified...Principal
- ...Description Job Description SerDes architect and development lead focused on PAM4 ADC and DAC based wireline technologies. The... ...information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans...Senior
$194k - $262k
...Intuit is seeking a Principal Program Manager in Mountain View, California, focused on Performance Management and Development. This role entails designing and managing critical performance cycles, ensuring alignment with strategic goals and operational excellence. The...Principal- ...A leading technology company in Mountain View is looking for an experienced AI Science Lead. You will lead a team to develop cutting-edge machine learning models that enhance customer experiences. The ideal candidate will hold a PhD/MS and possess strong skills in statistics...Principal
$194k - $262k
...A leading financial software company in Mountain View, California, is seeking a Principal Program Manager for Performance Management and Development. This role is crucial for driving company-wide talent strategy and managing performance evaluation processes. The ideal...Principal- ...Broadcom Inc. is looking for a Principal Software Engineer in San Jose, California, to design and develop high-performance Control Software and Firmware. This role emphasizes ownership and responsibility for product lifecycle from inception to production, involving extensive...Principal
$220.2k - $330.4k
...Industrial and Embedded IoT (IE‑IoT) BU leads the transformation of industries through... ...‑prem, and hybrid cloud scenarios. As a Principal Systems Solutions Architect, you will define... ...designs, Build POCs and pilot systems; instrument, profile, and optimize models and...PrincipalWork experience placementWork at office$209.09k - $303.34k
.... To achieve that we are building the leading tech stack for the automotive industry... ...Role Summary: The Technical Lead Sr Principal Software Engineer, BSW is a senior technical... ..., and root-cause debug using advanced instrumentation, fault injection, and performance...PrincipalSeniorPermanent employmentTemporary workWorldwide$148.1k - $282.1k
...Adobe is seeking a Principal Product Manager in San Jose to lead the vision and strategy for the Firefly Graph ecosystem. This role requires significant product management experience, with a strong emphasis on technical capabilities and user empathy. The ideal candidate...Principal- ...Akraya, Inc. is seeking a Principal Software Engineer to improve engineering velocity and developer experience by optimizing the Software Development Life Cycle (SDLC). This role is situated at our Santa Clara HQ, requiring in-office presence three days a week. The successful...PrincipalWork at office3 days per week
- ...NVIDIA Gruppe is seeking a Principal Software Engineer to lead the transformation of AI networking systems. Your deep expertise will guide strategic deployments and influence NVIDIA's networking technologies. This role involves engaging with customers and internal teams...Principal
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Sr. Principal Instrument Replacement Lead. Be the first to apply!
- senior automation controls engineer Milpitas, CA
- senior brand designer Milpitas, CA
- senior business analyst contract Milpitas, CA
- senior app developer Milpitas, CA
- senior database analyst Milpitas, CA
- legal senior counsel family office Milpitas, CA
- senior aws cloud engineer Milpitas, CA
- senior financial analyst remote Milpitas, CA
- senior cloud engineer Milpitas, CA
- senior manager financial planning & analysis Milpitas, CA


