Associate Director, Translational Science

Overview Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech is seeking an Associate Director, Translational Science as part of the Early Drug Development team based in Somerset, NJ . Role Overview The Associate Director of Translational Science will bridge the gap between early-stage discovery research and clinical development. This role requires a unique blend of deep immunological expertise and advanced computational proficiency. You will be responsible for designing and executing translational strategies, identifying biomarkers, and leveraging large-scale multi-omic datasets to provide actionable insights into mechanism of action (MoA), patient stratification, and drug resistance in both autoimmune and oncology disease areas. Key Responsibilities Translational Strategy: Lead the development and execution of program-specific translational plans from lead optimization through Phase II clinical trials. Data Integration & Analysis: Oversee the analysis of high-dimensional datasets (e.g., scRNA-seq, CITE-seq, flow cytometry, and spatial transcriptomics) to identify pharmacodynamic markers and predictive signatures, to interpret and provide insight into the biological mechanisms. Clinical Collaboration: Partner with Clinical Development and Clinical Operations to implement biomarker assays in clinical protocols and ensure high-quality data collection. External Partnerships: Manage relationships with Contract Research Organizations (CROs) and academic collaborators for specialized assay development and advanced data processing. Cross-Functional Leadership: Represent Translational Science on program teams, providing expert input on disease biology, target engagement, and competitive landscape. Scientific Communication: Author high-quality technical reports, regulatory documents (IND/IB/NDA), and contribute to peer-reviewed publications and conference presentations. Requirements PhD or MD/PhD in Immunology, Bioinformatics, Computational Biology, or a related field. 5+ years of experience in the biopharmaceutical industry or an equivalent academic leadership role within translational research. Extensive knowledge of human autoimmune disease and oncology diseases, specifically in areas such as immuno-oncology, autoimmune diseases, or cell therapy (CAR-T/TCR-T). Demonstrated experience with genomic data analysis. Practical and hands-on experience with data analysis pipelines, ability to guide data integration, knowledge integration from multiple datasets is essential. Proven track record in the development, validation, and clinical implementation of complex biomarkers. Experience working with relevant disease areas, deep understanding of the biological mechanisms related to diseases (autoimmune, oncology, or both). Strong understanding of regulatory requirements for biomarker-driven clinical trials. Excellent project management skills with the ability to lead multiple programs in a fast-paced environment. High scientific curiosity, driven, motivated in deep understanding of the biology behind both disease and therapies. Compensation and Benefits The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles. Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work. EEO Statement It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. #J-18808-Ljbffr Legend Biotech US