Research Associate in Department of Physiology

The Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for a Research Associate position in the Academic Support Staff. This appointment will be initially for one (1) year and continuation during that time period and renewal are based on satisfactory performance and availability of funding (limited to three (3) years). Expertise is required in the specific area of mass spectrometry-based proteomics, including experience with LC-MS/MS instrumentation, experimental design, and proteomics data analysis. Candidates should possess strong expertise in protein biochemistry, molecular biology, and quantitative proteomics approaches. A strong record of original peer-reviewed publications, scientific leadership, communication, and interpersonal skills is required. Applicants must have a Ph.D. or M.D./Ph.D. degree.

Responsibilities may include conducting independent and collaborative research in structural proteomics, chemical biology, and mitochondrial biology; developing and implementing mass spectrometry-based workflows including chemical crosslinking mass spectrometry (XL-MS), quantitative proteomics, and protein interaction mapping; operating and maintaining advanced LC-MS/MS instrumentation; analyzing complex proteomics datasets; mentoring students and trainees; contributing to manuscript preparation, grant writing, and collaborative research projects.

The successful applicant will have an opportunity to establish and lead new structural proteomics and crosslinking mass spectrometry capabilities within a newly established research program; develop independent research projects at the interface of proteomics, structural biology, neuroscience, and reproductive biology; collaborate with investigators across Penn's structural biology, proteomics, mitochondrial biology, and neuroscience communities; receive mentorship in laboratory leadership, grant writing, project development, and career advancement; and contribute to high-impact interdisciplinary research programs.

Candidates should have demonstrated experience designing and executing independent research projects and working effectively within collaborative multidisciplinary teams. Experience with Orbitrap-based mass spectrometry platforms, quantitative proteomics workflows, and advanced proteomics software tools is required.

Preferred qualifications include expertise in chemical crosslinking mass spectrometry (XL-MS), structural proteomics, protein interaction mapping, chemical biology, development of novel analytical methodologies, and computational analysis of proteomics datasets. Experience with mitochondrial biology, neuroscience, reproductive biology, cryo-EM, or integrative structural biology is desirable but not required.

Ph.D. or M.D./Ph.D.

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.