Research Specialist B

Research Specialist B - Contract - Philadelphia, PAReady to help advance the next generation of engineered cell therapies for blood cancers while playing a pivotal role in a leading translational research laboratory?Proclinical is seeking an experienced Research Specialist to join a large, collaborative translational research group of ~30 scientists working on engineered cellular therapies for blood cancers, including CAR T cells, CAR macrophages, and gene-edited hematopoietic stem cells. This is a hybrid role, split roughly evenly between two functions:Primary Responsibilities:The successful candidate is someone with hands-on rodent experience who is seeking a stable, central role in a busy academic laboratory, including candidates building research experience before applying to graduate or medical school. Training will be provided on lab-specific models, imaging workflows, and operational systems.Skills & Requirements:Experience with tumor xenograft or leukemia models, particularly in immunodeficient strains (NSG or similar)Experience with bioluminescent imaging (IVIS), bleeding, injectionFamiliarity with flow cytometry sample preparation or sterile cell cultureExperience with laboratory purchasing, inventory systems, or electronic lab notebooks (e.g., Benching)Previous work in an academic or industry research laboratoryThe Research Specialist B's responsibilities will be:In Vivo Research Support (~50%)Perform routine mouse procedures, including but not limited to intravenous, intraperitoneal, subcutaneous, and retro-orbital injections; tumor cell and cell-therapy product administration; and compound dosingCollect blood by submandibular, retro-orbital, or terminal cardiac puncture; process serum and plasma; aspirate bone marrowsPerform bioluminescent imaging (IVIS) to track tumor burden and cell trafficking, including luciferin administration, image acquisition, and quantificationConduct euthanasia and organ harvest (spleen, bone marrow, liver, lung, blood, tumor), and prepare single-cell suspensions for downstream flow cytometry and molecular analysesMonitor animal health and body condition, record clinical observations, and escalate concerns appropriatelySupport colony management in coordination with ULAR: cage census and record keepingMaintain meticulous, contemporaneous records in the electronic lab notebook and in study-specific data filesWork strictly within approved IACUC protocols; assist with protocol amendments, animal ordering, and per-diem trackingLaboratory Operations (~50%)Place and track orders for reagents, consumables, and equipment through Penn Marketplace and preferred vendors; reconcile packing slips, receipts, and invoicesMaintain inventory of high-use consumables, media, sera, cytokines, and antibodies; establish par levels and reorder points so critical items never run outReceive, unpack, log, and appropriately store incoming shipments, including cold-chain and controlled itemsMonitor and maintain cold storage: ?80 C and ?20 C freezers, 4 C refrigerators, and liquid nitrogen vessels - including temperature logs, alarm response, defrost scheduling, LN2 fills, and coordination of service callsMaintain freezer and cryotank inventories and sample-location databases; support periodic cleanouts and consolidationOversee shared equipment: routine maintenance, service contracts, calibration records, and coordination with vendors and core facilitiesMaintain lab safety and compliance: chemical inventory, SDS files, biohazard and sharps waste streams, autoclave use, and EHRS requirementsPrepare common stock solutions, buffers, and media for shared lab useHelp onboard and train new lab members on ordering procedures, storage systems, safety practices, and shared equipmentAssist the Laboratory Manager with space organization, expense tracking, and general day-to-day operationsRequired QualificationsBachelor's degree in biology, biochemistry, neuroscience, animal science, or a related field1-2 years of hands-on rodent experience, including injections, blood collection, and tissue harvestWillingness and ability to work with laboratory mice, including euthanasia and dissectionStrong organizational skills, attention to detail, and reliable record keepingAbility to manage competing requests from multiple investigators and prioritize effectivelyClear written and verbal communication; comfortable working as part of a large teamProficiency with standard office and data tools (Excel, email, shared drives)Ability to work independently and follow through on recurring responsibilities without promptingIf you are having difficulty in applying or if you have any questions, please contact Mike Raletz at View email address on click.appcast.io you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page. 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