Director IT Infrastructure, Operations and Security

Join Us in Tackling Autoimmune Disease at Its Root At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide. When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care. Why Work at Vor? Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases. Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond. Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome. Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies. The Digital, Data, and Technology (DD&T) organization is seeking a Director of IT Infrastructure, Operations & Security to design, build, and operationalize a scalable, enterprise-grade IT function in an evolving biotech environment. This leader will be responsible for defining and implementing the global Infrastructure, IT Operations, End-User Support, and IT Security capabilities required to support regulated commercialization and corporate operations. This role requires a hands-on strategic builder who can architect the operating model, implement foundational governance and controls, and transition the organization from reactive IT support to a proactive, secure, service-oriented global IT function. The successful candidate will combine strong technical depth with operational discipline and executive-level communication, ensuring that IT enables scientific innovation while maintaining compliance, security, and scalability. Key Responsibilities IT Strategy & Operating Model Define and implement the IT Infrastructure, Operations, Global Support, and IT Security organizational structure. Establish a scalable IT service delivery model aligned to biotech growth and regulatory requirements. Develop a 2–3 year technology roadmap covering infrastructure modernization, security maturity, and operational excellence. Implement governance, KPIs, SLAs, and service management frameworks (e.g., ITIL-based processes). Build and manage internal teams and external managed service providers (MSPs). Infrastructure & Cloud Services Design and operationalize enterprise infrastructure strategy across: Cloud platforms (e.g., Microsoft Azure or AWS) Hybrid networking and secure connectivity Identity & access management Endpoint management (Windows, macOS, mobile) Ensure high availability, disaster recovery, and business continuity planning. Standardize global site infrastructure for offices and lab environments. Oversee lifecycle management of hardware, software, and core systems. IT Operations & Global Support Build a scalable global support model (Service Desk, onsite support, executive support). Implement incident, problem, change, and asset management processes. Define support tiers (L1–L3) and escalation models. Establish a global IT Command Center capability for operational visibility. Improve employee experience through premium, personalized technical support. Manage vendor relationships and outsourced support partners where appropriate. IT Security & Compliance Establish and operationalize an enterprise IT security program partnership. Define cybersecurity policies, standards, and technical controls. Implement risk management, vulnerability management, and incident response processes. Ensure compliance with biotech-relevant regulations and frameworks (e.g., GxP, SOX, GDPR, HIPAA as applicable). Partner with Quality and Legal teams on audit readiness and documentation. Develop security awareness and training programs across the organization. Financial & Vendor Management Develop and manage IT operating and capital budgets. Rationalize vendor landscape and negotiate enterprise contracts. Drive cost transparency and optimize spend while enabling growth. Evaluate and implement managed service provider (MSP) partnerships where appropriate. Required Qualifications 10+ years of progressive IT leadership experience, including building infrastructure and operations functions. Experience in biotech, life sciences, pharmaceutical, or other regulated environments. Proven track record of designing and implementing scalable IT operating models. Deep knowledge of: Cloud infrastructure (Azure, AWS) Enterprise networking and security architecture Endpoint management and identity platforms IT service management frameworks Experience implementing cybersecurity programs and managing regulatory audits. Strong financial acumen with experience managing multi-million-dollar IT budgets. Demonstrated success leading global or multi-site teams. Experience in growth-stage biotech or pre-commercial environments. Familiarity with GxP, validated systems, and laboratory IT environments. CISSP, CISM, ITIL, or relevant technical certifications. Experience transitioning from decentralized IT to centralized global operations. The salary range for the Director IT Infrastructure, Operations and Security is expected to be between $205,000 and $235,000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job-related skills, experience, education or training, market factors, and work location. At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond. As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Please visit our website at for more information.