Senior/Principal DMPK Scientist - CNS Discovery (Hybrid)
Axonis
Axonis Therapeutics in Boston is seeking a Senior/Principal Scientist, DMPK to drive strategy from discovery through clinical development. You will collaborate with Chemistry and Toxicology teams to optimize ADME properties for CNS programs and lead human PK projections. The role emphasizes cross-functional leadership, data integrity, and external collaboration with CRO partners, aiming to advance lead compounds toward development candidates in a fast-growing, hybrid-work biotech environment. #J-18808-Ljbffr Axonis
- Axonis Therapeutics in Boston is seeking a Senior/Principal Scientist, DMPK to drive the program-level DMPK strategy and support discovery through early clinical development. This... ...Biology, and Toxicology, helping advance CNS programs with external partners and internal...PrincipalSenior
- We are growing our DMPK team at Axonis Therapeutics with a new Senior/Principal Scientist, DMPK role reporting to the... ...-functionally from discovery through clinical development... ...candidates within the CNS area. You will... ...global footprint and hybrid work environment. Responsibilities...PrincipalSenior
$168k - $252k
...DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing,... ...and agentic AI systems for drug discovery. In this role, you will work across modalities... ...Engineering.This is a Boston based, hybrid position requiring 3 days/week onsite...PrincipalSeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per week$168k - $252k
...agentic systems across drug discovery. Working at the intersection... ...scientifically rigorous AI co-scientists that enhance compound design,... ...efficiency.This is a Boston based, hybrid position requiring 3 days/... ..., data scientists, and senior leaders across a matrixed organization...PrincipalSeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per week$168k - $252k
...Vertex Pharmaceuticals seeks a Senior Principal Scientist to develop and deploy agentic AI systems for drug discovery. The role combines computational expertise with scientific leadership to create AI-enabled workflows that enhance small molecule and protein therapeutic...PrincipalSenior- ...Vertex Pharmaceuticals seeks a senior scientific leader to advance artificial intelligence... ...agentic systems in small-molecule drug discovery. This role bridges computational drug... ...project teams to develop and deploy AI co-scientists supporting design, analysis, and lead...PrincipalSenior
$179k - $236k
Reporting to the Chief Scientific Officer, this role leads DMPK strategy and oversees bioanalytical work across nonclinical and clinical... ...-on scientific leader. We are looking for an accomplished DMPK scientist with experience in PK and PK-PD study design, PK data analysis...PrincipalSenior$119.7k - $222.3k
...Summary LI#-Hybrid Location: Cambridge (... ...translation. Experience in late discovery into clinical... ...role overseeing ADME/DMPK project strategy in clinical... ...to be considered for Principal Scientist II. 4+ years of... ...to be considered for Senior Principal Scientist....PrincipalSenior$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific... ...for mass spectrometry-enabled discovery within the Quantitative Biosciences... ...with pharmacology, biology, DMPK, or translational science to...PrincipalSeniorFull timeFor contractorsLocal area$157k - $213k
...motivated and detail-oriented Scientist with strong expertise in... ...Metabolism and Pharmacokinetics (DMPK) sciences to support drug development... ...Lexington, MA office with a hybrid work arrangement.ExperiencePh... ...teams including bioanalysis, discovery research, toxicology,...SeniorContract workTemporary workSummer workWork at officeLocal area$184.2k - $253.2k
Does it excite you to translate DMPK insights into the design and optimization of complex... ...of this expansion, we are seeking a Principal Scientist to take a leading scientific role... ...and peptides) Establish and grow DMPK discovery platforms and bioanalysis capabilities...Principal$147.2k - $220.8k
...Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership... ...to advance programs from discovery through clinical development.... ...effectively to project teams, senior management, external collaborators...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours$115k - $215k
...strategic recommendations to project teams, senior leadership, and external collaborators... ...proteomics strategies that inform discovery, translational, and clinical-stage decision... ...discovery:Highly organized, solutions-oriented scientist with the ability to manage multiple...PrincipalSenior$138.6k - $257.4k
...seeking a highly motivated and experienced scientist to lead a small group of biologists... ...matrix teams to enable complex target discovery and validation across disease areas.... ...patients.Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition...PrincipalSeniorFull time- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...PrincipalSenior
$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout the JobImmunology and Inflammation Therapeutic AreaWe have an... ...reflect real-world needs.Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to...PrincipalSeniorFull time$146k - $236k
...finding is relevant to another. They will also serve as an expert test user for the Applied AI and Engineering teams, feeding field discoveries back as product requirements. The role owns the credibility of its analyses: transparent uncertainty, defensible assumptions, and...PrincipalSenior$146k - $236.5k
...venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here you will build the physics... ...simulation experience, at least part of it in a drug discovery setting (Sr. Scientist); 6+ years with demonstrated ownership...PrincipalSenior$214.1k - $337k
...Merck seeks a Senior Principal Scientist to lead mass spectrometry capabilities within the Quantitative Biosciences group in Boston. The role... ...strategic leadership, mentorship, and collaboration across discovery programs to advance drug discovery decision-making. Responsibilities...PrincipalSeniorLocal area$105.04k - $127.29k
...Senior Associate Scientist position within the Neuroscience Therapeutic Research Center focused on discovery biology for neurodegenerative, neuromuscular, and neuropsychiatric diseases.... ...multidisciplinary teams across biology, chemistry, DMPK, and computational biology...Senior- ...techniques relevant to pathogenic cell target discovery, depletion therapeutic development, and... ...teams, including in vivo pharmacology, DMPK, and technology groups, to drive... ...across projects. We are looking for a Senior Scientist I with a strong background in immunology...SeniorTemporary workLocal area
$138.6k - $257.4k
...Novartis Biomedical Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in Cambridge.This role is for... ...microenvironment biologyExperience supporting oncology drug discovery or early clinical development with image-based biomarker strategies...PrincipalSeniorFull time- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle biology . This is an opportunity for a scientific leader to advance portfolio projects...PrincipalSeniorLocal area
$208k - $286k
...maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary... ...learning, optimization, and automated scientific discovery. You will help define how AI systems navigate vast spaces...Principal$142.5k - $256.5k
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First...PrincipalPermanent employmentFull timeWork from home- Pioneering Intelligence is seeking a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms for autonomous... ...on Bayesian inference, reinforcement learning, optimization, and automated discovery. #J-18808-Ljbffr Pioneering IntelligencePrincipal
$152.6k - $283.4k
...biomarker science that helps transform promising discoveries into life-changing medicines. As a Sr Principal Scientist / Associate Director, Biomarker Assay... ...programs. In addition, we provide flexible and hybrid working options, where possible, and a minimum of...PrincipalSeniorFull timeContract workLocal areaFlexible hours- ...Bristol Myers Squibb seeks a Principal Scientist for its Discovery BioSciences Genomics team in Cambridge, MA. The role focuses on wet lab research using multi-omics approaches—genomics, functional genomics, and spatial transcriptomics—to advance oncology drug discovery...Principal
- Johnson & Johnson is seeking a Principal Scientist, Animal Genetic Engineering - Antibody Discovery, to design and engineer mouse models for advanced antibody discovery. Based in Cambridge, MA or Spring House, PA, the role integrates mouse genetics, CRISPR, B cell immunology...Principal
$148k - $208k
...training, lab integration, etc.), to identify and mitigate risks from scientific superintelligence while retaining the core scientific discovery capabilities of the stack. The initial focus of this team will be to build and implement a bespoke safety strategy for Lila,...PrincipalSeniorFull timeWork at officeLocal areaFlexible hours
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