Senior Research Technologist-Rochester Flow Cytometry Core

Independently sets up and performs experiments and procedures in support of lab goals and grant commitments (e.g. assays, cell/tissue culture, animal studies, etc.). Contributes to the planning, design and modification of studies and experiments in the research lab setting. Monitors results, reports unusual outcomes and suggests modifications. Collects, enters, summarizes, and analyzes data. May oversee and assist with the training of residents, fellows and temporary lab personnel in lab techniques. Works with minimal supervision and performs assignments independently as discussed and approved by Principal Investigator.Additional Information:The Optical Microscopy and Cell Analysis Core is seeking a motivated individual to support flow cytometry-based research projects across the Mayo Clinic enterprise. The successful candidate will be responsible for day-to-day instrument calibration, sample acquisition and high-speed cell sorting, data management and backup, routine maintenance, quality control, and troubleshooting of flow cytometry instrumentation. The individual will train and assist researchers with experimental design, multicolor flow cytometry panel development and optimization, instrument setup, and interpretation of flow cytometry data. Additional responsibilities include supporting assay development, data analysis using platforms such as FlowJo, maintaining detailed records and standard operating procedures, and ensuring a safe, organized, and collaborative core facility environment. Experience with conventional and/or spectral flow cytometry platforms and the ability to provide technical support for multiple research projects are highly desirable.This is a limited tenure position that has been approved for two years that may have the possibility of turning into a regular position.This vacancy is not eligible for sponsorship. We will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. Benefits HighlightsMedical: Multiple plan options.Dental: Delta Dental or reimbursement account for flexible coverage.Vision: Affordable plan with national network.Pre-Tax Savings: HSA and FSAs for eligible expenses.Retirement: Competitive retirement package to secure your future. Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.Equal OpportunityAll qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization. Requires bachelor's degree in biology, chemistry, or other relevant science with 4 years of research laboratory experience. Master's degree in biology, chemistry, or other relevant science preferred.Preferred Experience and Qualifications:Demonstrated expertise in multicolor flow cytometry panel design, optimization, and troubleshooting, including experience with high-parameter conventional and/or spectral flow cytometry. Ability to develop and validate complex panels, identify technical issues, and implement solutions to ensure high-quality and reproducible data.Hands-on experience operating and maintaining flow cytometry instrumentation, including platforms such as BD Biosciences, Cytek, Bio-Rad, or equivalent systems. Experience performing routine quality control, instrument performance monitoring, basic troubleshooting, and coordinating preventive maintenance and service activities is preferred.Strong knowledge of experimental design, assay development, and flow cytometry data analysis. Experience using software such as FlowJo or similar platforms to support investigators with study design, data interpretation, compensation, spectral unmixing, and validation of research assays.Experience working in a shared resource, core facility, or collaborative research environment supporting multiple users and projects simultaneously. Demonstrated ability to prioritize workflows, maintain detailed records, develop standard operating procedures, and provide technical support in a service-oriented setting.Candidates who have published first-author peer-reviewed research articles demonstrating the development, optimization, or application of multicolor flow cytometry panels will be given special consideration.Full timePosting Date: 2026-06-22