General Manager (Drug Asset Lead)

About Formation Bio

Formation Bio is a tech and AI driven pharma company differentiated by radically more efficient drug development.


Advancements in AI and drug discovery are creating more candidate drugs than the industry can progress because of the high cost and time of clinical trials. Recognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Formation Bio partners, acquires, or in-licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients. The company is backed by investors across pharma and tech, including a16z, Sequoia, Sanofi, Thrive Capital, John Doerr, Spark Capital, SV Angel Growth, and others.


You can read more at the following links:

• Our Vision for AI in Pharma
• Our Current Drug Portfolio
• Our Technology & Platform

At Formation Bio, our values are the driving force behind our mission to revolutionize the pharma industry. Every team and individual at the company shares these same values, and every team and individual plays a key part in our mission to bring new treatments to patients faster and more efficiently.

About the Position:

As General Manager for a Formation Bio asset, you will be the accountable leader -responsible for translating the investment thesis into action and progressing the asset towards value inflection with speed, efficiency, and leverage. You will own the asset strategy, budget, and execution rhythm, ensuring momentum, clarity, and disciplined delivery across functions. GMs at Formation Bio own outcomes: they make high-stakes decisions (including no-go calls), anticipate inflection points, and deploy resources to maximize value. You will align financial and operational decisions with the asset strategy and work in close partnership with a Clinical Lead and other cross functional partners and stakeholders to advance the asset with scientific rigor, operational excellence, and AI-enabled leverage.
Responsibilities

• Refine and deliver the strategy for the asset and define key results that ladder up to asset objectives.
• Drive and own business outcomes-including asset P&L, budgets, ROI, and value inflection with speed.
• Lead a team of full-time and contract team members, forecasting and pulling resources (functional experts, tech, and other services) as needed.
• Partner with the assigned Tech Lead, Clinical Development Lead, and other functional subject matter experts (e.g., CMC, Regulatory, Data Science) to drive asset strategy and execution.
• Establish and run team rituals (charters, prioritization touchpoints, etc.) that ensure clarity, accountability, and disciplined execution.
• Anticipate and surface tradeoffs, risks, and governance needs, while maintaining autonomy for operational decisions.
• Develop and maintain comprehensive governance tools such as asset development roadmaps, registers and dashboards.
• Track and manage against success metrics, including milestone adherence, team efficiency and overall asset value.
• Provide ongoing strategic updates to the Formation Bio Leadership Team, ensuring alignment with broader portfolio and company-level strategy.

About You

• Outcome-Driven: You optimize for value creation and speed, not process for its own sake.
• Radically Accountable: You own timelines, budgets, risks, and tradeoffs without relying on matrix ambiguity.
• AI-Native: You naturally embed AI and automation into team culture, workflows, and decisions.
• Generalist With Range: You flex across disciplines, knowing when to go deep or bring in expertise and when to rely on the team.
• Influential Without Authority: You earn trust and alignment among SMEs and functional leaders without direct reporting lines.
• Structured & Decisive: You run the team like a business-with sharp prioritization, clear charters, and disciplined execution.
• Comfortable in Ambiguity: You thrive in dynamic environments, simplify complexity, and adapt quickly.
• Strategically grounded with tactical depth : You seamlessly connect high-level vision to detailed, practical action.

Total Compensation Range: $311,000 - $388,500

Compensation Individual compensation is determined by several factors, including role scope, geographic location, and skills & experience. Your offer will reflect where you fall within the range based on these considerations. In addition to base salary, we offer equity, comprehensive benefits, and generous perks. If the posted range doesn't match your expectations, we still encourage you to apply!

Where We Hire Formation Bio is prioritizing hiring in key hubs, primarily the New York City and Boston metro areas, with a hybrid model requiring 3 days per week in office. Applicants from the Research Triangle (NC) and San Francisco Bay Area may also be considered. Please apply only if you reside in these locations or are willing to relocate

Equal Opportunity Formation Bio is committed to building a diverse and inclusive team. We are an equal opportunity employer and welcome candidates from all backgrounds. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, ancestry, sex (including pregnancy, childbirth, breastfeeding, and related medical conditions), gender identity or expression, sexual orientation, age, disability, genetic information, marital status, military or veteran status, or any other characteristic protected by federal, state, or local law.