Analytical Chemistry Principal Research Associate

Job Description

Vertex is seeking an on-site Principal Research Associate, Analytical Chemistry to support medicinal chemistry programs through small molecule purification, analytical characterization, property assays and workflow optimization. This role will focus on HPLC and SFC purification, with a strong emphasis on SFC expertise, to help deliver high-quality compounds and data that enable rapid discovery efforts.

Key Duties and Responsibilities:

• Purify small molecules using HPLC and SFC in support of medicinal chemistry programs.
• Develop and optimize SFC purification methods, including chiral and achiral separations.
• Perform analytical testing to confirm purity, identity, and quality of compounds.
• Run small molecule property assays such as solubility, lipophilicity, and stability assessments.
• Partner closely with medicinal chemists to support project timelines and compound delivery needs.
• Troubleshoot purification and assay issues and help improve lab workflows.
• Maintain accurate records and clearly communicate results to project teams.
• Support routine operation and maintenance of chromatography instruments.

Knowledge and Skills:

• Small molecule purification and characterization
• Laboratory data systems and electronic lab notebooks
• Familiarity with discovery informatics or compound tracking systems
• Experience with software development, scripting, or coding
• Ability to work effectively in cross-functional teams
• Strong written and verbal communication skills
• Demonstrated ability to work independently, manage priorities, and drive technical work with limited oversight

Education and Experience:

• Requires a Master's and 2+ years, or a Bachelor's and 5+ years of experience, or the equivalent combination of education and experience
• Experience supporting small molecule discovery or medicinal chemistry programs
• Strong hands-on experience with HPLC and/or SFC purification
• Strong organizational, communication, and collaboration skills

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Pay Range:
$85,700 - $128,500

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.


Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.


Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.


Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io