Senior Scientist, Protein and Antibody Bioconjugation

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)

About the Role:
We seek a Bioconjugation Sr. Scientist to join our Bioconjugates Research Group. The successful candidate will contribute to the design, generation, and characterization of novel bioconjugate modalities, including antibody-peptide conjugates (APC), antibody-oligonucleotides conjugates (AOC), and antibody-drug conjugates (ADC). Your expertise in protein and antibody conjugation will enable you to have a significant impact on Neurocrine's pipeline of innovative therapeutics.

Your Contributions (include, but are not limited to):

• Carry out laboratory functions, plan and design experiments, and apply technical knowledge and skills to achieve project goals in a precise and timely manner
• Design, synthesize, and characterize antibody conjugates using state-of-the-art bioconjugation methods, purification processes, and biophysical techniques
• Optimized conjugation protocols using novel chemistries and techniques for a variety of bioconjugates modalities such as peptide-antibody (APC), oligonucleotides-antibody (AOC) and small molecule antibody (ADC) conjugates. Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is desirable
• Identify and troubleshoot critical issues within conjugation processes, resolving them promptly to ensure consistent progress and quality
• Collaborate cross-functionally with chemists and other teams to design and establish linker-payload biologic SAR (structure-activity relationships), supporting scientific discovery and project progression
• Tracks progress against the timelines of ongoing projects, ensuring timely delivery of results and providing regular updates to project teams and stakeholders
• Effective communication of scientific rationale, results, and interpretation at project, team and departmental meetings, contributing to strategic discussions
• Establish and maintain excellent working relationships with critical collaborators throughout the company
• Maintains accurate and well-organized lab notebooks and batch records to document all experimental procedures and findings, ensuring compliance with regulatory requirements and internal standards
• Represents our function in cross-functional meetings and contributes to decision-making at the program level, driving strategy, execution, and delivery of critical milestones. Communicate scientific rationale, data, and interpretations effectively in project, team, and departmental meetings
• Contribute to project and platform strategy, including proposing new technologies, approaches, or areas of exploration

Requirements:

• BS/BA degree in biology and 4+ years of relevant industry experience OR
• MS/MA degree in biology and 3+ years of relevant industry experience OR
• PhD or equivalent and some relevant experience
• In-depth knowledge of modern protein bioconjugation (peptide, protein, and antibody) purification, and analytical characterization
• Hands-on experience with antibody conjugates with various payload classes, including peptides, oligonucleotides, and small molecules. Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is an advantage
• Strong background in analytical characterization of bioconjugates, specifically RP-HPLC, LC-MS
• Proficiency in purification techniques for antibodies and antibody conjugates such as RP-HPLC, FPLC-AKTA, size-exclusion (SEC), ion exchange (IEX), tangential flow filtration (TFF)
• Independently design and implement conjugation and purification strategies applying stay-of-the-art knowledge in the field
• Strong publication record of accomplishment
• Understanding of peptide, siRNA, and protein structure and associated biophysical techniques to assess structure, stability, and behavior in solution is desirable
• Experience in formulation strategies for conjugate molecules is a plus
• Excellent interpersonal skills with strong oral and written communication abilities
• Assimilates data and research findings outside of Neurocrine and applies them to new scientific projects
• Prioritizes teamwork above all else
• Must be able to work independently with supervision as needed
• Understands the team's role within the larger organization and can discuss changes, progress, and issues in relation to other areas
• Excellent written and verbal communication skills, with the ability to present complex scientific data clearly to diverse audiences
• Demonstrates strong problem-solving and analytical thinking skills, showing a proactive attitude towards exploring new approaches
• Maintains a comprehensive knowledge of principles and theories, providing solutions to a wide range of complex problems
• Able to meet multiple deadlines across various projects/programs with a high degree of accuracy and efficiency
• High attention to detail and commitment to data integrity, reproducibility, and quality documentation

#LI-LS1

Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the .

The annual base salary we reasonably expect to pay is $110,800.00-$151,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.