Sr. Scientist/Sr. Scientist II - Pharmacology

Generous. Innovative. Leadership-driven. Family-oriented. Socially responsible. Founded in 1998, Glaukos Corporation is an ophthalmic pharmaceutical and medical technology company focused on developing and commercializing novel therapies for the treatment of glaucoma, corneal disorders, and retinal diseases.Our mission at Glaukos is to truly transform vision by pioneering novel, dropless therapies that can meaningfully advance the standard of care and improve the lives of patients suffering from chronic, sight-threatening eye diseases. Innovation is at the core of everything we do, and we are resolute in our commitment to challenge conventional thinking with new treatment alternatives that are supported by real science, robust clinical evidence, and an unrelenting focus on patients. Our constant pursuit of game-changing technologies that disrupt legacy treatment paradigms is encapsulated in the Glaukos mantra “We’ll Go First,” which articulates our willingness to take chances, our determination to forge new ground, and our commitment to continuous improvement in all that we do. Our company completed an initial public offering in June of 2015, and our shares are traded on the New York Stock Exchange under the ticker symbol “GKOS”. Our global headquarters is in Aliso Viejo, California with additional locations in San Clemente, California, and Burlington, Massachusetts.Glaukos Corporation is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected Veteran Status, or any other characteristic protected by applicable federal, state, or local law. All offers of employment are contingent upon the successful completion of a background check, including successfully passing a drug screen, based on the position and local regulations.Senior Scientist / Senior Scientist II, PharmacologyHow You’ll Contribute:Glaukos is seeking a highly motivated and scientifically rigorous Senior Scientist / Senior Scientist II to join the Pharmacology team. This role will advance the Glaukos pipeline through pharmacology strategies and studies supporting discovery, translation, clinical dose selection, and regulatory submissions.The successful candidate will report to the Head of Pharmacology and work in a highly cross-functional environment. The individual will provide pharmacology expertise across glaucoma, retinal disease, and anterior segment programs, supporting studies of small molecules, biologics, sustained-release technologies, medical devices, and combination products.What You’ll Do:Develop and implement pharmacology strategies to support candidate selection, lead optimization, IND-enabling development, clinical dose justification of ophthalmic therapeutic programs.Design, oversee, and interpret in vitro, ex vivo, and in vivo pharmacology studies to evaluate mechanism of action, potency, efficacy, pharmacodynamics, biomarker response, exposure-response relationships, and translational relevance.Manage outsourced pharmacology studies with CROs, academic laboratories, and external collaborators, including study concept development, vendor selection, contracting support, protocol development and approval, study amendments, data review, final report review, timeline tracking, budget oversight, and delivery of key milestones.Represent Pharmacology on cross-functional project teams, contribute to integrated development plans, and present study designs, data interpretation, scientific rationale, and recommendations to support evidence-based decision-making.Author and review pharmacology-related sections of regulatory and development documents, including IND submissions, Investigator’s Brochures, regulatory briefing packages, NDA/BLA submissions, study reports, literature summaries, and supporting scientific materials. Support responses to regulatory agency questions by providing clear scientific rationale and data-driven interpretation.Maintain awareness of advances in ophthalmology, ocular pharmacology, translational models, drug delivery technologies, and relevant competitive and scientific landscapes to inform program strategy.Prepare high-quality technical reports, presentations, manuscripts, posters, and scientific publications, and communicate research findings effectively to internal stakeholders, external collaborators, and scientific or industry audiences.How You’ll Get There:Ph.D. in Ophthalmology, Neuroscience, Pharmacology, or a related life science discipline, with 4+ years of relevant industry experience; postdoctoral or industry experience in ocular research is preferred.Strong knowledge of ocular pharmacology, ocular anatomy and physiology, ocular pathobiology, nonclinical disease models, and translational endpoints relevant to ophthalmic drug and device development.Demonstrated experience designing, executing, analyzing, and interpreting mechanism-of-action, efficacy, pharmacodynamic, biomarker, or translational pharmacology studies.Strong analytical and problem-solving skills, with the ability to critically evaluate complex datasets, identify key conclusions and limitations, and communicate findings clearly to scientific and cross-functional audiences.Experience in ophthalmic drug development, ocular drug delivery, sustained-release technologies, biologics, medical devices, or combination products is highly desired.Experience managing CROs, academic collaborators, or external scientific partnerships is desired.Familiarity with nonclinical study design, translational pharmacology, regulatory expectations, and data packages used to support IND, NDA, BLA, or equivalent regulatory submissions is preferred.Excellent verbal and written communication skills.Ability to thrive in a fast-paced, collaborative biotechnology environment, manage multiple priorities, work independently, and contribute effectively within matrixed project teams.Ability to travel up to 15% of the time.Flexible on level for those with ophthalmology industry experience #GKOSUSFull timePosting Date: 2026-08-11