Director, Tax Operations

Build Our Future Together At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Director of Tax Operations to own the day-to-day management of the company's global tax reporting and compliance functions for the US. Reporting to the Head of Tax Operations, the Director runs the operational execution of tax accounting (ASC 740), U.S. compliance, indirect taxes, SOX controls, audits, and the systems and data that support them. In this role you will modernize the tax operating model — embedding artificial intelligence (AI), automation, and analytics into everyday tax work while maintaining rigorous controls and human review. The Director coordinates with Tax Strategy counterparts on planning, technical positions, and shared or cross-functional work, and manages the U.S. and Ireland operations as a single, well-run team.

When & Where: This position is full-time and will sit in our Sleepy Hollow, NY office four days per week.

Discovery Your Role:

• Manage ASC 740 tax accounting including provisions, reconciliations, financial statement disclosures, and external audit coordination
• Ensure SOX-compliant internal controls over tax reporting processes, including AI and automation-enabled workflows
• Oversee all U.S. federal, state, and international tax compliance, filings, payments, and audit-ready documentation
• Manage tax credits (R&D, orphan drug), indirect taxes (sales/use, property, excise), and tax audits/examinations
• Monitor and implement regulatory changes including OECD Pillar Two, U.S. CAMT, and international statutory requirements
• Lead tax operations AI strategy by identifying use cases, piloting solutions, and establishing responsible-use guardrails
• Own tax technology platforms, analytics tools, and data initiatives while driving process transformation and team upskilling
• Partner with Tax Strategy and cross-functional stakeholders while leading and developing the Tax Operations team

This Role Requires:

Bachelor's Degree in Tax, Accounting, Finance, or a related field plus at least 10 years of progressive corporate tax experience (or equivalent combination of education and professional experience) working for or with publicly traded, multinational companies; a combination of Big 4 and in-house experience is strongly preferred. Deep expertise in ASC 740, including provisions, uncertain tax positions, financial statement disclosures, and strong U.S. federal and state income tax experience, with exposure to indirect taxes. Life sciences or biopharmaceutical industry experience nice to have. International and statutory reporting experience (FRS 102, IFRS); Ireland experience a plus nice to have. Familiarity with the OECD global minimum tax (Pillar Two) and the U.S. corporate alternative minimum tax (CAMT) nice to have. Experience leading tax technology, automation, or data-analytics initiatives nice to have.

Salary Range (annually) $183,100.00 - $305,200.00

Does this sound like you?

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

For additional information about Regeneron benefits in the U.S., please visit For other locations, additional information will be provided during the recruitment process.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site.

We are also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA- approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.