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Senior Mechanical Engineer, Machine Design

$130k - $140k

Foresite Labs

Senior Mechanical Engineer, Machine Design

Location: San Diego, CA

Job Type: Full-Time

$130,000 - $140,000

Machine Design
  • Own the design of precision mechanical systems including frames, motion elements, fixtures, and actuation mechanisms
  • Perform tolerance stack-ups and define GD&T for precision assemblies
  • Develop and manage mechanical error budgets (alignment, motion accuracy).
  • Analyze stiffness, deflection, vibration, and fatigue using analytical methods and FEA
  • Design mechanisms that balance performance, cost, manufacturability, and reliability
Thermal Control Hardware
  • Design thermal control systems including heaters, heat exchangers, insulation, cold plates, airflow systems, and structural thermal paths
  • Translate temperature stability and uniformity requirements into hardware specifications
  • Perform thermal modeling and first-principles heat transfer calculations (conduction, convection, radiation)
  • Develop and maintain thermal error budgets (drift, gradients, response time)
  • Collaborate with electrical and firmware engineers on sensor placement and control strategy integration
Fluid Control Hardware Design
  • Design fluid handling assemblies including manifolds, tubing routing, fittings, valves, pumps, and reservoirs
  • Perform flow calculations (pressure drop, flow rate, Reynolds number)
  • Support material selection for chemical compatibility and biocompatibility
  • Integrate fluidic subsystems with thermal and mechanical assemblies
  • Develop leak testing and validation strategies
Analysis & Validation
  • Build structured analytical models to predict mechanical, thermal, and fluidic performance
  • Maintain subsystem-level error budgets (mechanical, thermal stability, flow accuracy)
  • Design and execute validation testing for temperature stability, fluid accuracy, drift, and mechanical robustness
  • Perform structured root cause analysis when performance targets are not met
  • Support DFMEA and risk assessment activities
Prototyping & Integration
  • Assemble and debug mechanical, thermal, and fluidic prototypes
  • Instrument systems for temperature, flow, and mechanical performance measurement
  • Iterate quickly based on test results and integration feedback
  • Support alpha and beta system builds
Manufacturing & Documentation
  • Create detailed mechanical drawings with proper GD&T
  • Participate in DFM/DFA reviews
  • Work with vendors on machined, sheet metal, molded, and fluidic components
  • Support transition from prototype to low-volume production
Qualifications

Required
  • B.S. or M.S. in Mechanical Engineering or related field
  • 5-8+ years of experience in precision machine design, thermal systems, and/or fluid handling hardware
  • Strong foundation in tolerance analysis and error budgeting
  • Experience performing thermal and fluid flow calculations
  • Proficiency in 3D CAD (e.g. SolidWorks)
  • Hands-on experience building and testing hardware
Preferred
  • Experience in bioinstrumentation, medical devices, diagnostics, or scientific equipment
  • Experience designing closed-loop temperature-controlled systems
  • Experience with microfluidic or low-volume reagent handling systems
  • Familiarity with FEA tools for structural and thermal analysis
  • Experience selecting materials for chemical compatibility
  • Experience supporting early-stage production builds
What We're Looking For
  • Analytical thinker who quantifies performance limits and tradeoffs
  • Strong mechanical fundamentals with systems-level intuition
  • Comfortable owning subsystems end-to-end
  • Hands-on builder who enjoys working in the lab
  • Clear communicator across electrical, firmware, fluidics, and systems teams

We are an equal opportunity employer. We thrive on diversity and collaboration.
Vacancy posted 3 days ago
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