Biological Scientist

Biological Scientist Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is seeking a Biological Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD. This position designs, executes, and optimizes advanced molecular, cellular, genomic, and functional studies using genome engineering, stem cell biology, high-throughput screening, imaging, sequencing, and specialized analytical platforms to support mechanistic and translational research. The role also provides scientific and technical leadership in laboratory operations, quality control, instrumentation, data analysis, documentation, and multidisciplinary collaboration, contributing to research programs, publications, presentations, and grant-related activities. Additional qualifications: Field of Study: Biology, Molecular Biology Skills: Cell culture, Molecular biology, Molecular Biology Genome Engineering, Cell Stem Cell Biology, Genomics Sequencing, Protein Cellular Assays, High-Throughput Screening, Advanced Instrumentation, Microscopy, Cell Banking Quality Control, Laboratory Operations, Scientific Analysis Communication Deliverables: Run Validation - Ad-Hoc Inspect Equipment - Ad-Hoc Meet with lab members to present updates - Weekly Molecular biology, genome engineering, and functional genomics work products related to experimental reports, protocols, construct maps, plasmid inventories, and technical documentation related to the design, execution, and optimization of molecular biology and cell-based experiments, including CRISPR genome editing, cloning, construct design, gene expression analysis, and functional genomics studies - Ad-Hoc Mammalian cell culture work products, laboratory reports, and technical documentation related to the maintenance, expansion, characterization, and experimental use of stem cell lines, and differentiated cell populations - Ad-Hoc Stem cell differentiation work products, protocols, differentiation records, assay results, and technical reports related to stem cell differentiation, optimization of culture conditions, and implementation of automated and high-throughput cell culture platforms - Ad-Hoc Genetic construct design and generation work products, construct designs, plasmid maps, cloning records, genome-editing validation reports, and associated documentation related to molecular cloning, plasmid engineering, CRISPR/Cas-mediated genome editing, and viral vector development - Ad-Hoc DNA, RNA, and protein isolation work products, laboratory reports, quality control documentation, and technical records related to the isolation, quantification, characterization, and storage of DNA, RNA, and protein samples from cellular and tissue specimens - Ad-Hoc Genomic sample preparation and sequencing support work products, sequencing preparation records, library preparation documentation, quality control reports, and technical documentation related to PCR, qPCR, next-generation sequencing (NGS), transcriptomics, and single-cell sequencing workflows - Ad-Hoc Multi-omics work products, sequencing reports, sample tracking records, analytical summaries, and technical documentation related to transcriptomic and genomic data generation workflows and coordination of downstream bioinformatics analyses - Ad-Hoc Cell characterization and functional analysis work products, assay reports, experimental data, and technical documentation related to Western blotting, immunocytochemistry, immunofluorescence staining, and related protein and cellular characterization studies - Ad-Hoc Tissue processing and histological analysis work products, microscopy datasets, tissue preparation records, cryostat sectioning documentation, image analysis reports, and technical documentation supporting cellular and molecular characterization studies - Ad-Hoc High-throughput assay development work products, assay development plans, validation reports, screening datasets, and technical documentation related to the development, optimization, validation, and implementation of high-throughput screening platforms, including bioluminescence-, fluorescence-, and reporter-based assays - Ad-Hoc Laboratory inventory management work products, inventory databases, reagent tracking systems, laboratory resource catalogs, and documentation related to establishing, maintaining, and updating inventories of reagents, antibodies, plasmids, cell lines, small molecules, consumables, and experimental protocols - Ad-Hoc Salary Range $80,000 —$85,000 USD Axle Informatics