Senior Associate Scientist, Biology

About the Company Parabilis Medicines is a clinical‑stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high‑impact protein targets long‑considered undruggable. The company has developed a new class of stabilized, cell‑penetrant alpha‑helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Massachusetts, Parabilis is advancing a focused pipeline of first‑in‑class therapies across rare and common cancers, including zolucatetide (FOG‑001) and investigational degraders for prostate cancer. The Opportunity The Senior Associate Scientist will play a hands‑on role in discovery and translational biology, leading assay development, generating mechanistic insights, and supporting oncology programs from lead optimization to biomarker development. Responsibilities Design, develop, and optimize multiplexed cell‑based and high‑throughput assays to ensure robust, reproducible, and scalable data generation. Improve assay throughput and efficiency through automation or semi‑automation, proactively identifying risks and refining experimental strategies. Drive mechanistic understanding of novel oncology targets through hypothesis‑driven experimentation (e.g., CRISPR, knockdown, tool compounds, rescue strategies). Integrate internal data, literature, and public datasets to inform experimental design, interpret results, and refine scientific hypotheses. Contribute to biomarker discovery efforts and support translational strategy development. Collaborate cross‑functionally with chemistry, DMPK, in‑vivo pharmacology, and data science teams to advance programs from hit‑to‑lead through IND‑enabling studies. Support assay transfer to CROs, including data review, troubleshooting, and performance tracking. Present findings clearly to project teams and maintain rigorous documentation, including ELN entries and SOP development. Qualifications Education & Experience Bachelor’s degree with 5+ years or Master’s degree with 4+ years of industry experience in a relevant field. Experience in discovery biology, with exposure to oncology or related therapeutic areas preferred. Technical Expertise Strong hands‑on experience developing and executing cell‑based and high‑throughput assays, including automation. Quantitative approach to assay design and data quality, with a focus on reproducibility, robustness, and controls. Experience designing and executing experiments independently and generating actionable insights from complex datasets. Familiarity with a subset of the following: CRISPR/Cas9, gene editing/knockdown, overexpression systems qPCR/RT‑qPCR, Western blotting, flow cytometry Reporter assays (e.g., luciferase, NanoBRET), protein–protein interaction assays Mammalian cell culture and functional assays (e.g., proliferation, apoptosis) High‑throughput screening formats (e.g., 384‑well) Omics approaches (e.g., RNA‑seq, proteomics) preferred Automation platforms, ELN systems (e.g., Dotmatics), and SOP authorship Core Capabilities Strong experimental rigor and data‑driven decision‑making Ability to manage multiple projects and priorities in a fast‑paced environment Effective cross‑functional collaboration and clear scientific communication Ownership mindset with ability to independently drive workstreams Demonstrated ability to utilize AI tools for day‑to‑day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus. Able to work on‑site and attend in‑person meetings. Core Values Growth‑Minded : We invent a new class of medicines for targets considered impossible to drug, approaching challenges with curiosity, humility, and adaptability. Interdependent : We collaborate as a team to shift drug discovery paradigms and deliver better treatment options. Patient‑Focused : We are deeply focused on patient outcomes, with all energy directed toward science that translates into impact. All‑In : We commit fully to solving the hardest scientific challenges and delivering highly effective new classes of drugs. Salary & Benefits Base salary range: $88,000–$108,000 per year, depending on experience and qualifications. Parabilis offers an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support overall well‑being. Equal Opportunity Statement As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law. Location 30 Acorn Park Drive, Cambridge, MA 02140 | #J-18808-Ljbffr Parabilis Medicines