Principal Scientist
Scorpion Therapeutics
Role Principal Scientist in Translational Informatics and Predictive Sciences at BMS, focusing on applying computational, bioinformatics, and machine learning approaches to large-scale clinical and real-world datasets in solid tumor oncology. Responsibilities analyze high-dimensional molecular data (e.g., genomics, proteomics), develop predictive models, generate mechanistic insights, and partner with biomarker scientists and clinical teams to inform treatment response and resistance mechanisms. Provide scientific leadership, mentorship, and communicate complex analyses to cross-functional stakeholders. Qualifications Bachelor's (8+ yrs), Master's (6+ yrs), or PhD (4+ yrs) with expertise in high-throughput molecular data and proficiency in R/Python, AI, and statistics. Preferred: experience with spatial ’omics, oncology, and drug development in translational sciences or clinical settings. High-value specifics: oncology (solid tumors), translational research, biomarker discovery, AI/ML applications, and collaboration across R&D stages. Work setup: not specified, but the role involves cross-functional engagement within BMS's research environment. #J-18808-Ljbffr Scorpion Therapeutics
- ...MassachusettsCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** are seeking a highly skilled Scientist to join our Biologics Discovery team and lead antibody discovery efforts. We are looking for someone who thinks carefully about...Principal
$137k - $215.27k
...information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Pharmacovigilance Scientist, Senior Scientist ensures regulatory compliance and safety of Takeda's products by managing large projects, developing innovative...PrincipalMinimum wageLocal area$138.6k - $257.4k
...Description SummaryWe are seeking a highly motivated and experienced scientist to lead a small group of biologists with advanced imaging... ...for patients.Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition Location: Cambridge, MA,...PrincipalFull time$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout the JobImmunology and Inflammation Therapeutic AreaWe have an exciting opportunity to join Sanofi's Translational Biology team as a Senior Principal Scientist within the Type 2 Immunology...PrincipalFull time$175k - $225k
...follow @ScholarRock on X and on LinkedIn.Summary of Position:Scholar Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for biomarker strategy and execution across preclinical programs in...PrincipalFull time$146k - $236k
About Pioneering IntelligencePioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio...Principal$179k - $236k
...nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will...Principal$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group in Boston. This role will help shape...PrincipalFull timeFor contractorsLocal area$146k - $236.5k
About the Role:FL117, a venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here you will build the physics layer of a drug development AI platform. You will characterize how binders engage their targets and...Principal$168k - $252k
...high-value opportunities across the design-make-test-analyze (DMTA) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation, hypothesis generation, and decision-making. Although the...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$198.9k - $269k
...range of science and engineering domains within Amazon, and you will join the team at the forefront of this research.As a Principal Applied Scientist, you will play a pivotal role in shaping the definition, vision, and development of product features from beginning to...PrincipalFlexible hours$188k - $259k
About This Role Biogen is seeking a Sr. Principal Scientist, Oral Drug Product Development to provide scientific and strategic leadership for the development of small molecule oral drug products. This role leads scientific and engineering efforts supporting formulation...PrincipalFull timeTemporary workLocal area$119.7k - $222.3k
Job Description SummaryLocation: Cambridge MAInternal: Principal Scientist I/IILI#-HybridThe individual will provide scientific and operational support to Study Quality and Compliance group within the Toxicology line function of Preclinical Safety (PCS). Key areas of responsibility...PrincipalPermanent employmentFull time$126k - $234k
...of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and...PrincipalFull timeRemote work$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate...PrincipalFull time$190.8k - $300.3k
Job DescriptionWe are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Cardiovascular & Metabolic and Infectious Diseases/Vaccines portfolios.This role will lead the design...PrincipalFull timeFor contractorsLocal areaFlexible hours$147.2k - $220.8k
...therapeutics and other emerging modalities. The candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours$142.5k - $256.5k
..., as a shared discovery resource. This role is intended for a scientist ready to own and evolve a core discovery capability, led by scientific... ...independence, judgment, and ownership consistent with a Principal Scientist role.Here’s What You’ll Bring to the Table (...PrincipalPermanent employmentFull timeWork at officeWork from home$119.7k - $222.3k
...preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of...PrincipalFull time$208k - $286k
...cycles, continuously improving their performance while maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms.In this role you will develop methods that enable...Principal$216k - $297k
...reasoning efforts on both the technical and application levels. You will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-class biological reasoning engines. You will be responsible for...Principal- Lila Sciences in Cambridge, MA is looking for a Senior/Principal Scientist specializing in Small Molecule Therapeutics. This role focuses on leading hit identification through DNA-encoded libraries (DEL) and executing robust screening methodologies in collaboration with...Principal
- Sanofi is seeking a Senior Principal Scientist in Cambridge, MA to lead preclinical immunology programs and shape translational strategies that inform clinical development and lifecycle management. You will drive collaborations with Development, Medical Affairs, and Commercial...Principal
$142.5k - $256.5k
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First...PrincipalPermanent employmentFull timeWork from home$138k - $207k
Job DescriptionGeneral Summary:Vertex Pharmaceuticals is seeking a highly experienced and motivated Principal Scientist to join the Vertex Manufacturing Center (VMC) Kilo Lab in a dual-capability role that is central to our drug substance development mission. This is an...PrincipalFull timeSummer workFlexible hours$176.2k - $277.3k
...DescriptionBoston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics - Principal ScientistOur company is a global health care leader with a... ...a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company’s...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours$208k - $286k
...elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational projects that accelerate pharmaceutical R&D across the...Principal- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...Principal
$141k - $188k
About This Role The Biomarkers and Systems Biology group is seeking a highly motivated Principal Scientist to contribute to the development and implementation of biomarker and bioanalytical strategies supporting discovery, translational, and clinical-stage programs. The...PrincipalFull timeTemporary workLocal areaFlexible hours$145.5k - $218.3k
Job DescriptionGeneral Summary:The Principal Scientist Aseptic Control is recognized as having expertise in the principals and application of sterile and low bioburden processing technologies and providing technical support for manufacturing of cell and gene therapy (C&...PrincipalFull timeContract workSummer workRemote workFlexible hours2 days per week
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