Principal Scientist - Quantitative Translational Scientist

Regeneron’s Precision Medicine Quantitative Biomarker team (PMQBS) is seeking a Principal Scientist with a blend of deep biomarker and translational-science expertise coupled with advanced computational and analytical skills. This role will focus primarily on the Oncology portfolio, and will encompass exploratory analyses and visualization of omics, EHR, wearable sensor, imaging, and other biomarker data. This position is also involved in the development of tools and dashboards for querying, visualizing, and cleaning data. The individual will work collaboratively with internal and external groups to assure data integrity, best practices for analytics and data visualization, and offering strategic insights to drive Precision Medicine objectives.

A Typical Day in the Role Might Look Like:

• Set and refine quantitative biomarker strategies across multiple programs, aligning with Precision Medicine Strategy Leads and senior stakeholders.

• Translate program objectives into testable hypotheses, analytical roadmaps, and decision criteria that inform clinical development and asset strategy.

• Architect exploratory analyses of multi-modal datasets (genomic, transcriptomic, proteomic, metabolomic, clinical, and other biomarkers) to generate actionable insights.

• Define and review statistical frameworks, including hypothesis testing, modeling approaches, and power/sample-size analyses, ensuring appropriate interpretation.

• Oversee the correct application of statistical models on integrated datasets and drive clear, decision-oriented interpretation for translational and clinical teams.

• Contribute to the vision for scalable, reproducible pipelines and automated workflows that support enterprise-wide biomarker discovery and clinical development.

• Direct the design and enhancement of computational workflows for novel biomarkers; evaluate, integrate, or build tools as needed.

• Provide guidance on data cleaning, integration, and visualization standards to enable robust, interpretable analyses.

This role may be for you if you:

• Proficient in statistical modeling/regression, machine learning, and related data integration/blending techniques.

• Experienced in implementing scalable workflows on cloud platforms (AWS, GCP, or Azure)

• Experienced in Linux and/or cloud environments, shell scripting, and notebook-based workflows.

• Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption.

• Experience with version control and AI coding assistants such as Claude Code is strongly preferred.

• Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption.

To be considered for this role, you must have at minimum a PhD with 2 years, or Masters with 5 years of relevant industry experience in one of the following or otherwise related quantitative fields: Computer Science, Computational Biology, Systems Biology, Quantitative Biology, Bioinformatics, Data Analytics, Biostatistics. A working understanding of Clinical trials is a strong plus.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit . For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)