Senior Director, Pharmacokinetics, Dynamics, Metabolism and Bioanalysis, Protein Therapeutics

Job Description

At our Company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee builds on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating an organization that is inspired by invention and founded on a culture of respect and collaboration. At our Company’s Research Labs Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Responsibilities

• Oversee the design and interpretation of pharmacokinetic, immunogenicity and ADME studies for protein therapeutics across multiple disease indications and therapeutic areas.
• Mentor and manage a team of high performing PDMB scientists and managers (multi-tiered organization) supporting protein therapeutic optimization (PK, distribution, translational strategy) and discovery bioanalytics (ligand binding assays, mass spectrometry).
• Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safety.
• Contribute to global PDMB strategy through close collaboration with project teams in Boston (MA), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize protein therapeutic drug candidates.

Education Minimum Requirement

• Ph.D (with 7+ years relevant experience) in biochemistry, pharmacology, pharmaceutical sciences, protein engineering, molecular biology, bioengineering, or related STEM field; Relevant experience that includes a record of increasing responsibility and independence in a similar industrial/academic setting.

Required Experience and Skills

• Demonstrated experience leading protein therapeutic discovery efforts as a group leader or independent project-team representative within a highly collaborative environment.
• Strong understanding of protein therapeutic bioanalytical, ADME, FcRn biology, target‑mediated drug disposition (TMDD) and immunogenicity concepts for modalities such as monoclonal antibodies or engineered bispecifics.
• Proven track record of managing scientists and leading cross‑functional teams in a drug discovery or development setting.
• Experience contributing to development and execution of translational PK/PD efficacy relationships, human dose predictions and other useful quantitative pharmacology applications in a discovery setting.
• Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast‑paced environment.

Preferred Experience and Skills

• Hands‑on experience performing or interpreting data from translational PK/PD/efficacy or physiologically‑based pharmacokinetic (PBPK) models (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB).
• Proven track record supporting immunology or oncology‑based programs with experience spanning from early discovery through IND‑enabling effort.
• Expertise with designing and troubleshooting ligand binding assays or hybrid‑LC/MS assays for the detection and quantitation of protein therapeutics in various matrices (non‑GLP).
• Experience working within a research‑driven pharmaceutical company.

Equal Employment Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC.

Compensation and Benefits

Salary range: $194,100.00 - $305,600.00. This range reflects the pay we would offer for this role in good faith at the time of posting. The final salary within the range will be based on several factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable. We offer a comprehensive package of benefits, including medical, dental, vision, health care and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information is available at the company’s compensation and benefits website.

Job Details

Employee status: Regular. Relocation: Domestic. Visa sponsorship: No. Travel requirements: 10%.