Principal Scientist Systems & Disease Biology
Mass Digital Health
Sanofi is seeking a Principal Scientist in Cambridge, MA to decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate discovery to patient impact. The role demands deep expertise in complex cellular analytics, multi-omics, and ML/AI deployment, with a track record of leading projects, mentoring junior scientists, and presenting results to decision points in drug discovery. This position is located in the US and offers collaboration across teams. #J-18808-Ljbffr Mass Digital Health
$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate...PrincipalFull time$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout... ...join Sanofi's Translational Biology team as a Senior Principal... ...understanding of the immune system - and innovative pipeline -... ...immunology and inflammatory disease pathways Experience with...PrincipalFull time$146k - $236k
...Pioneering Intelligence (PI) is building AI systems that accelerate translational decision... ...uncertainty across compound, mechanism, and disease dimensions Translate scientific... ...problems that require expert judgment: novel biology, new modalities, or high-consequence analyses...Principal$179k - $236k
...accomplished DMPK and bioanalytical scientist with experience in PK study... ...in rare disease, genetic medicine, or nucleic... ...therapeuticsFamiliarity with LNP platform biology and delivery landscapeFamiliarity... ..., our applicant tracking system, and may also be reviewed using...Principal$146k - $236.5k
...bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular... ...or HPC infrastructure; own system setup, parameterization, QC,... ...pharmacology, and external structural biology and assay partners; turn... ...COVID-19, curing intractable diseases, improving human health, preempting...Principal$208k - $286k
...Intelligence is building an autonomous system capable of exploring large... ...We are looking for a Senior Principal Scientist to invent and build the next... ...mathematics, computational biology, physics, or related) with a... ...-19, curing intractable diseases, improving human health,...Principal$216k - $297k
...to build polyintelligent AI systems that unify human scientific... ...intelligence, and nature’s biological signals into multi-modal, multi... ...talented machine learning scientists innovating on model architectures... ...-19, curing intractable diseases, improving human health, preempting...Principal$208k - $286k
...and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead... ...omics, biomolecule design, multi-o, systems biology, and scientific literature mining, ensuring... ...against COVID-19, curing intractable diseases, improving human health, preempting...Principal$141k - $188k
About This Role The Biomarkers and Systems Biology group is seeking a highly motivated Principal Scientist to contribute to the development and implementation of biomarker... ...implementation of Biomarker methods (TE, PD, Disease) supporting the biomarker strategy. Lead the...PrincipalFull timeTemporary workLocal areaFlexible hours$115k - $209k
...Summary We are seeking a (Senior) Scientist to join Pioneering... ...translational leaders into autonomous systems that identify, evaluate, and... ...Background in computational biology, bioinformatics, or a... ...COVID-19, curing intractable diseases, improving human health, preempting...Casual work$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical company... ...for patients with serious diseases by unlocking biologically important targets long considered... ...optimize, and qualify new assay systems and disease-relevant models—including...PrincipalShift work$121.28k - $202.13k
...combining our understanding of the immune system with cutting-edge technology to transform... ..., technology, and talent to get ahead of disease together. Job Description The... ..., oligonucleotide synthesis, or chemical biology or related fields. ~2+ years of industry...PrincipalFull timeLocal area$142.5k - $256.5k
The RoleModerna is seeking an Individual to lead host strain, vector, and expression system strategy for E. coli-based production of recombinant enzymes, plasmids, and related biological materials supporting Moderna’s technology platforms and pipeline programs.This role...PrincipalPermanent employmentFull timeWork at officeWork from home$138.6k - $257.4k
...highly motivated and experienced scientist to lead a small group of... ...discovery and validation across disease areas. This position is part... ...Job Title: Senior Principal Scientist/Associate DirectorPosition... ...leadership at the intersection of biology and advanced imaging-based...PrincipalFull time$175k - $225k
...atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a... ...need.As a global leader in myostatin biology, a field focused on proteins that regulate... ...accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific...PrincipalFull time$168k - $252k
...accelerate the application of AI and agentic systems across drug discovery. Working at the... ...them into scientifically rigorous AI co-scientists that enhance compound design, knowledge... ...associated with protein therapeutics, biologics, or other emerging therapeutic modalities...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist... ....EducationPh.D. or equivalent in biology, pharmacology, analytical chemistry,... ...pharmacology principles to interpret biological systems and guide experimental strategy.Proven...PrincipalFull timeFor contractorsLocal area- ...Senior/Principal Scientist, MPN Biology, Translational Sciences PharmaEssentia Innovation Research Center... ...new biologics for challenging diseases in the areas of hematology, oncology... ...and primary human cellular and tissue systems to generate comprehensive pharmacology...PrincipalContract work
$117k - $201.25k
...build a world where complex diseases are prevented, treated, and... ...searching for the best talent for a Principal Scientist, Animal Genetic Engineering... ...genetic engineering, B cell biology, and therapeutic antibody... ...engineer the mouse humoral system - for example, to broaden...PrincipalContract workLocal areaImmediate start$190.8k - $300.3k
...an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker... ...& Metabolic and Infectious Diseases/Vaccines portfolios.This role will lead... ...integrate therapeutic mechanism, disease biology, pharmacodynamics, patient heterogeneity...PrincipalFull timeFor contractorsLocal areaFlexible hours$142.5k - $256.5k
...an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within... ...across oncology and autoimmune disease programs. The role spans concept development... ...lead identification, including biological and therapeutic-area research, target...PrincipalPermanent employmentFull timeWork from home$176.2k - $277.3k
...Metabolism and Bioanalytics - Principal ScientistOur company is a... ...and collaborative Principal Scientist (director-level equivalent) to... ...neuroscience and infectious disease efforts as well. The successful... ...drug disposition on disease biology, pharmacological response (PK...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours$175k - $225k
...atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a... ...need.As a global leader in myostatin biology, a field focused on proteins that regulate... ...join the Bioanalytical Sciences team as Principal Scientist, Bioanalytical Specialist to provide...PrincipalFull time$114.1k - $211.9k
...planning. The Biomarker Strategy Lead will partner closely with Biology, In Vitro, In Vivo, Data Science and Biomarker Development to... ...including target engagement, pharmacodynamics, patient stratification, disease activity, and mechanism-based biomarkers.Experience leading...PrincipalFull timeLocal areaFlexible hours- ...patient datasets, identifying disease-associated cellular states... ...clinical teams. Requires a Ph.D. in biology or related field, 2+ years... ..., and machine learning scientists Requirements ~ Ph.D. or... ...understanding of molecular and systems biology with diverse data types...Principal
$260.3k - $409.7k
...exciting opportunity for a physician-scientist to join our group as a Principal Scientist (Clinical Director) in... ...Development in the Infectious Diseases Therapeutic Area.Translational Medicine... ...and behavioral responses to study biological activity in humansProviding...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle... ..., including neuromuscular diseases related to nucleotide repeat expansions...PrincipalLocal area
$108.5k - $201.5k
...Description SummaryInternal Position Title: Principal Scientist I/IILocation: Cambridge, MA, #LI-Onsite... ...biomarker assay development within Disease Area X (DAx). This position is integral... ...DesiredAnalytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration...PrincipalFull timeRelocation package$152.6k - $283.4k
...into life-changing medicines. As a Sr Principal Scientist / Associate Director, Biomarker Assay Development... ...renal, liver, fibrosis, and emerging disease areas, you will collaborate with... ...Skills DesiredAnalytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical...PrincipalFull timeContract workLocal areaFlexible hours- ...seeking an accomplished, creative, and highly collaborative scientist to lead the Cellular Biology function. The ideal candidate will bring deep... ...developing cell-based translational models of human hematologic diseases. This leader will play a pivotal role in advancing the...Principal
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