Senior Scientist, In Vivo Pharmacology
Scorpion Therapeutics
Senior Scientist — Cell Therapy (Thymmune) Responsibilities: Design, execute, and interpret in vivo studies to assess efficacy, safety, pharmacology, biodistribution, persistence, and mechanism of action of iPSC-derived thymic cell products. Develop/refine preclinical mouse models for immune reconstitution, immunosenescence, aging, and immune tolerance. Investigate cellular/molecular mechanisms driving thymic regeneration, T-cell development, immune tolerance, and immunosenescence. Implement high-dimensional immune profiling (e.g., flow cytometry, RNA-seq) and functional assays (T-cell activation, cytotoxicity, mixed lymphocyte reaction); develop biomarker strategies. Collaborate with iPSC Research, Process Development, and Analytical Development on potency/efficacy/safety-related product attributes. Generate robust PoC/pharmacology/MoA data packages to support candidate selection and nonclinical development. Analyze, interpret, and communicate study results; maintain accurate documentation and data integrity. Assess literature/competitive landscape; evaluate new therapeutic opportunities. Mentor junior team members. Minimum Requirements: PhD in immunology, stem cell biology, regenerative medicine, or related field. 5+ years preclinical model experience, including in vivo mouse studies; immunological assay development. Strong knowledge of immunology/thymus biology/T-cell development/immune reconstitution/tolerance. Independent project execution (design, study execution, analysis, interpretation, presentation). Rodent handling, tissue collection/dissection, multiple routes of administration (IV/IP/SQ, etc.). Hands‑on in vitro work with primary human/murine cells; experience developing immunological assays (MLR, T‑cell activation, cytotoxicity). Multi‑color flow cytometry; qPCR/ddPCR; histology; ELISA/MSD; statistical analysis and troubleshooting. Excellent written/verbal communication; collaborative fast‑paced environment experience. Preferred Qualifications: 1+ year nonclinical/IND-enabling/regulatory authoring experience (PoC, pharmacology, MoA, translational sciences). Knowledge of immunosenescence, age‑related immune dysfunction, tumor immunology, autoimmunity, transplantation immunology/tolerance. Publications and/or IP contributions. Benefits: Eligible employees may participate in comprehensive benefits (medical/dental/vision/prescription, wellness resources, 401k/ESPP, paid time off & paid parental leave, disability, and more). Location/Work: Cambridge, MA; fully onsite; occasional weekend work. #J-18808-Ljbffr Scorpion Therapeutics
$100k - $155k
...near South Station. POSITION SUMMARY: Atalanta is seeking a highly skilled and motivated Associate Scientist/Senior associate Scientist to join the in vivo pharmacology group to support Atalanta’s drug discovery programs. This individual will have extensive hands‑on experience...SeniorContract work- ...Job Description Job Description Scientist / Senior Scientist, In Vivo Pharmacology & Translational Biology Location: Boston, MA Company: Tevard Biosciences, Inc. Full time: In person Join Tevard Biosciences and help lead our efforts to develop transformative...SeniorFull time
Tevard Biosciences
Boston, MA19 days ago - Antares Therapeutics in Boston is looking for a highly motivated Scientist II/Sr. Scientist I in In‑Vivo Pharmacology with focus on immunology. The successful candidate will design and execute in vivo studies, particularly in mouse models of autoimmune disease. This role...Senior
- Bristol Myers Squibb seeks a Senior Associate Scientist, In Vivo Pharmacology, Oncology Discovery Biology, to advance early-stage oncology programs in Cambridge, MA. The role emphasizes in vivo and ex vivo models, cross-functional teamwork, and clear communication of scientific...Senior
$127.5k - $170k
...autoimmune disorders.Who you areFor scientists who prefer the frontier over... ...'d love to hear from you.The Senior Scientist is responsible for... ...of proof-of-concept, pharmacology, and mechanism-of-action studies... ...Design, execute, and interpret in vivo studies to assess the...SeniorCasual work$52.52k - $97.54k
We are seeking a motivated and skilled Senior Associate Scientist to support validation and execution of our imaging studies using preclinical in vivo oncology- models. This role is central to our preclinical research team and involves building CDx and clinically relevant...SeniorWeekend work$105.04k - $127.29k
Job Title: R1603459 : Senior Associate Scientist, In Vivo Pharmacology, Oncology Discovery Biology Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual...SeniorHourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work$145k - $185k
...Job Description Job Description Scientist II/Sr. Scientist I, In-Vivo Pharmacology (Must Have Immunology Experience) Salary Band: $145,000-$185,000... ...join our In Vivo Pharmacology team at the Scientist or Senior Scientist level. This individual will play a critical...SeniorAntares Therapeutics
Boston, MA6 days ago$118k - $178k
...passion will drive real-world impact as you contribute to life-changing treatments. We are seeking an experienced Senior Scientist , In Vivo Pharmacology to join a multidisciplinary In Vivo Cell Therapy Discovery team developing innovative viral vectors for oncology....SeniorTemporary workWork at officeFlexible hours3 days per week$126k - $234k
...Summary#LI-Hybrid Internal Title: Principal Scientist II or Senior Principal ScientistLocation: Cambridge... ...will also work closely with clinical pharmacology and pharmacometrics groups to support... ...and interpretation of preclinical in vivo and in vitro studies to support...SeniorFull time$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific... ...spectrometry and quantitative pharmacology across discovery programs,... ...capability supporting in vitro and in vivo pharmacology, advise...SeniorFull timeFor contractorsLocal area- United Therapeutics Corporation, Cambridge, MA, is seeking a Senior Scientist to advance our lead iPSC-derived thymic cell therapy program. You will design and execute proof-of-concept and pharmacology studies in relevant animal models, applying immunology and stem cell...Senior
$105k - $127k
...of-concept. Position Summary We are seeking a Senior Associate Scientist with strong in vivo skills, experience with standard molecular biology/biochemical... .../background in neuroscience to join our in vivo pharmacology group. As part of the Neuroscience Thematic Research...SeniorHourly payFull timeContract workTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work$98.7k - $183.3k
...team. These include agent stability, in vitro studies, and in vivo biodistribution studies. The candidate will also have a role in... ...fieldBackground in chemistry/radiochemistryInterest/experience in pharmacology and/or PK researchStrong technical writing and oral...SeniorContract workFlexible hours$126k - $160k
...seeking a highly motivated and experienced Senior Scientist to join our research team. The... ...expertise in cell isolation and sorting, in vivo/ in vitro mouse studies, gene-silencing... ...Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Biomedical Sciences, or a...Senior- Scorpion Therapeutics seeks a Senior Scientist to lead cell therapy research focused on thymic iPSC-derived products. You will drive in vivo studies, model development, and biomarker discovery to support nonclinical development. Strong collaboration with immunology and...Senior
$100k - $155k
...POSITION SUMMARY: Atalanta is seeking a highly motivated Senior Associate Scientist to join our Research team and support the discovery and... ...perform cell-based and tissue-based assays, support in vivo pharmacology studies, and collaborate closely with multidisciplinary...Senior- ...in Cambridge, MA is seeking an exceptional Scientist or Senior Scientist to lead discovery efforts in cardiovascular... ...disease, bridging in vitro and in vivo studies. The role emphasizes target validation, mechanistic pharmacology, and collaboration with computational...Senior
- Perceptive Inc. in Needham, MA is seeking a Senior Associate Scientist to support validation and execution of imaging studies in preclinical oncology... ..., manage procurement, ensure SOP adherence, supervise in vivo tasks, monitor animal health with the AV, and maintain...Senior
- United Therapeutics invites a Senior Scientist to lead preclinical research for iPSC-derived thymic cell therapies at our Cambridge, MA site. You will design in vivo studies, build relevant mouse models, and generate MOA data to advance our immunology platform for aging...Senior
- ...blockbuster drug space. The Role We are seeking a highly motivated Senior Scientist, Neuropharmacology to join our growing team. This... ...hands-on experience designing, executing, and interpreting in vivo pharmacology studies that inform efficacy, safety and the mechanism of...Senior
- Eli Lilly and Company seeks a skilled scientist to join its Drug Discovery team as an Advisor. This senior role focuses on discovering novel in vivo CAR products by screening, testing, and driving studies. Candidates will collaborate with experts in LNP and RNA delivery...Senior
- ...motivated, collaborative and resourceful scientist/senior scientist with extensive experience in... ...teams including delivery, analytical, pharmacology, and manufacturing to advance platform... ...CAR-T cell expansion, flow cytometry, ex-vivo processing, etc). Previous experience...SeniorFull time
- ...immunologically "cold" tumors. We're looking for a Senior Scientist with deep in vitro immunology expertise... ...optimize, and execute in vitro and ex vivo cellular assays leveraging primary... ...Build and run T cell engager‑specific pharmacology assays — including T cell‑dependent...SeniorFull timeWork at office
$129k - $203.1k
...(PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization... ...across therapeutic areas; Integrate in vitro and in vivo data to build PKPD, PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms...SeniorFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- Senior Scientist - Immunology and Inflammation Senior Scientist - Immunology and Inflammation Get... ..., utilizing advanced in vitro and ex vivo skin models. Apply expertise in cytokine... ...Scientist/Sr. Scientist for in vitro Pharmacology Waltham, MA $90,000.00-$110,000.00 1 week...SeniorFull timeContract workPart timeH1bWork at officeVisa sponsorshipShift work
- ...Job Description Job Description Scientist/Senior Scientist, Biology Lead – Kidney Experience... ...deep expertise in both in vitro and in vivo kidney biology, renal disease... ...biology, kidney disease models, in vivo pharmacology/efficacy studies, and translational assay...Senior
RAPTOR MEDICINES INC
Allston, MA19 days ago $142.22k - $172.34k
...sites in Cambridge and Seattle, scientists focus on novel targets and... ...state-of-the-art in vitro, in vivo and ex‑vivo models of Cancer... ...for co‑authoring non‑clinical pharmacology study reports and scientific... ...Chat with Ripley. R1605020 : Senior Scientist, Translational...SeniorHourly payFull timeContract workTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work- ...please visit us at . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description Scientist I, In Vivo Pharmacology Job Description: The Discovery Neuroscience In Vivo Pharmacology group in Cambridge, Massachusetts, is seeking a...Full timeTemporary workLocal area
AbbVie Inc.
Cambridge, MAa month ago $146k - $236k
...milestone decisions (target engagement, therapeutic window, modality feasibility, competitive differentiation) Quantify probability of pharmacological success by integrating uncertainty across compound, mechanism, and disease dimensions Translate scientific complexity into...Senior
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