Manager / Senior Manager, Program Management - Clinical Operations

About Artiva Artiva is clinical-stage, publicly-traded biotechnology company focused on developing natural killer (NK) cell-based therapies for patients suffering from devastating autoimmune diseases and cancers. Artiva’s lead program, AlloNK®, is an allogeneic, off-the-shelf, non-genetically modified NK cell therapy candidate designed to enhance the antibody-dependent cellular cytotoxicity effect of monoclonal antibodies to drive B-cell depletion. AlloNK is delivered in the outpatient setting with no required hospitalization. AlloNK is currently being evaluated in three ongoing clinical trials for the treatment of B-cell driven autoimmune diseases. This includes two company-sponsored trials, one in systemic lupus erythematosus for patients with or without lupus nephritis, and a basket trial across autoimmune diseases (Rheumatoid Arthritis, Systemic Sclerosis, Idiopathic Inflammatory Myopathies and Sjögren’s Disease), as well as an investigator-initiated basket trial in B-cell driven autoimmune diseases. Artiva’s pipeline also includes CAR‑NK candidates targeting both solid and hematologic cancers. Artiva was founded in 2019 as a spin‑out of GC Cell, formerly GC Lab Cell Corporation, a leading healthcare company in the Republic of Korea, pursuant to a strategic partnership granting Artiva exclusive worldwide rights (excluding Asia, Australia and New Zealand) to GC Cell’s NK cell manufacturing technology and programs. Artiva is headquartered in San Diego, California. For more information, visit Job Summary Artiva is seeking a Manager/Sr. Manager, Program Management to support the execution of clinical-stage programs, including randomized controlled trials (RCTs) and ongoing Phase 2 studies. This role will partner closely with Clinical Operations, Clinical Development, Data Management, and external vendors to ensure trials are executed efficiently, on time, and with high quality. This individual will focus on driving operational rigor, maintaining cross-functional alignment, and ensuring clear visibility into timelines, risks, and performance across clinical programs. Duties / Responsibilities Clinical Program Execution Support end-to-end program management of clinical trials, including RCT startup, enrollment, execution, and closeout activities Develop and maintain integrated clinical timelines, aligned with key milestones and deliverables Track progress across sites, vendors, and internal teams to ensure timely execution Cross-Functional Coordination Partner with Clinical Operations, Clinical Development, Biostatistics, Data Management, and Regulatory to ensure alignment across all aspects of trial execution Coordinate inputs and dependencies across functions to maintain program continuity Support communication across internal teams and external stakeholders Vendor & CRO Oversight Assist in oversight of CROs and other vendors to ensure deliverables are met on time and within scope Track vendor performance against timelines, budgets, and quality expectations Escalate issues and support resolution in collaboration with Clinical Operations Risk & Issue Management Identify and track risks related to site activation, enrollment, protocol adherence, and data delivery Support development and execution of mitigation strategies Ensure timely escalation of critical issues impacting study timelines or quality Data Tracking & Reporting Develop and maintain dashboards to track enrollment, site activation, data flow, and key study metrics Prepare clear, concise program updates for cross-functional teams and leadership Ensure consistent reporting across ongoing clinical studies Governance & Communication Support clinical governance meetings, including agenda setting, materials preparation, and follow-ups Ensure decisions, actions, and dependencies are clearly documented and tracked Drive accountability across teams for agreed-upon deliverables Requirements Bachelor’s degree in life sciences or related field 5–8+ years of experience of program management in biotechnology, pharmaceutical, or clinical research settings Proven experience supporting or managing clinical trials (Phase 2 and/or Phase 3 preferred) Solid understanding of clinical trial operations, including site activation, patient enrollment, and vendor management Strong organizational and project management skills Ability to manage competing priorities and other tasks as needed Preferred Experience working with CROs and external vendors Familiarity with clinical systems (e.g., CTMS, EDC) Exposure to randomized controlled trials (RCTs) PMP or similar certification (a plus, not required) Core Competencies Strong execution and organizational skills Ability to manage multiple priorities in a fast-paced environment Effective cross-functional communication and collaboration Attention to detail with the ability to see the bigger picture Proactive, solutions-oriented mindset In addition to a great culture, we offer: A beautiful facility An entrepreneurial, highly collaborative, and innovative environment Comprehensive benefits, including: Medical, Dental, and Vision Group Life Insurance Long Term Disability (LTD) 401(k) Retirement Plan Employee Assistance Program (EAP) Flexible Spending Account (FSA) Paid Time Off (PTO) Company paid holidays, including the year-end holiday week Our recognition program, Bonus.ly, is where you can trade in points earned for things you want. If all this speaks to you, come join us on our journey! Base Salary: $130,000 - $180,000. Exact compensation may vary based on level, skills and experience #J-18808-Ljbffr Artiva Biotherapeutics Inc.