Associate Principal Scientist, Discovery Oncology

We are seeking a highly motivated and innovative Associate Principal Scientist to join our Discovery Oncology team in South San Francisco. The successful candidate will have a strong track record in oncology and drug discovery and will lead the conception, design, and execution of discovery‑stage research programs. In this role, you will partner closely with cross‑functional teams across the organization to advance differentiated cancer therapies from target validation through early development. Key Responsibilities Design, establish, and optimize in vitro and ex vivo assays to elucidate mechanisms of action and assess therapeutic potential. Make timely, data‑driven decisions that balance innovation, risk, and experimental rigor. Communicate scientific strategy, rationale, and results clearly to internal teams and help build external scientific presence through publications, conference presentations, and collaboration. Drive ideation and early‑stage discovery efforts to deliver competitive oncology programs, leveraging internal expertise and emerging technologies. Qualifications Education Ph.D. in Cancer Biology, Cell Biology, Pharmacology, Immunology, Biochemistry, or a related discipline with four (4) or more years of relevant oncology drug discovery experience. Required Experience and Skills Deep expertise in tumor biology and immune oncology, including cancer genomics and oncogenic signaling. Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods. Extensive hands‑on in vitro experience designing, executing, and analyzing multi‑color flow cytometry and mechanistic cell‑based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts). Demonstrated ability to drive innovative research, evidenced by high‑impact publications, patents, and/or successful advancement of discovery programs. Passionate, creative, and collaborative scientist committed to improving outcomes for people living with cancer. Excellent oral and written communication skills, a positive, team‑oriented mindset, and strong leadership potential. Preferred Experience and Skills Hands‑on experience with different therapeutic modalities (e.g., small molecules, mAbs, ADCs and TCEs). Extensive hands‑on experience designing, executing, and analyzing in vivo mouse model data to evaluate therapeutics. Required Skills Biochemistry Cancer Cell Biology Cancer Research Cell Biology Immuno‑Oncology In Vitro Biology In Vitro Research In Vitro Studies Molecular Biology Oncology Tumor Biology Preferred Skills Current Employees apply Current Contingent Workers apply Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. If you need an accommodation during the application or hiring process, please click here. Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights and EEOC GINA Supplement. We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. Salary & Benefits Salary range: $159,600.00 - $251,200.00. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at Job posting end date: 07/10/2026. A job posting is effective until 11:59:59 PM on the day before the listed job posting end date. Please ensure you apply to a job posting no later than the day before the job posting end date. Location & Travel San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance. Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance. Additional Details Employee status: Regular Relocation: Domestic/International VISA Sponsorship: Yes Travel requirements: 10% Flexible work arrangements: Not applicable Shift: 1st - Day Valid driving license: No Hazardous material(s): N/A #J-18808-Ljbffr