Principal/Sr. Principal Scientist - Development

Principal Scientist The Department of Translational Safety at Genentech seeks a Principal Scientist in Toxicology to lead safety assessment and provide toxicology representation for drug development programs, with a focus on oncology, cardiovascular, respiratory, and metabolism portfolios, including small molecules, immunomodulators, bi‑specific antibodies, ADCs, cancer vaccines, and cellular therapeutics. Responsibilities Scientific leadership in the design and implementation of safety assessment strategies to support program advancement and decision‑making. Preparation and review of regulatory documentation. Preparation and review of study reports and manuscripts. Representation of Genentech in meetings with regulatory authorities. Investigations into mechanisms of toxicity. Proactive management of potential safety liabilities and communication of impact to teams and governance committees. Mentoring and providing support to inter‑ and intra‑departmental initiatives. Qualifications PhD or equivalent in toxicology or a relevant field, with 3+ years of industry experience in toxicology. Extensive experience in drug development and interaction with global regulatory authorities. Experience in oncology and cardiovascular, respiratory, or metabolism therapy areas with modalities such as small molecules, degraders, and ADCs. Evidence of a consistent and extensive record of impact internally and externally. Strong decision‑making, complex problem solving, critical data analysis and interpretation skills. Excellent written and verbal communication skills and ability to build cross‑functional collaborations within and outside Genentech. Board certification in toxicology is desirable. Salary & Benefits The expected salary range is $141,500–$262,900 (primary location California). Actual pay will be determined based on experience, qualifications, geographic location, and other factors permitted by law. A discretionary annual bonus may be available. This position qualifies for benefits as detailed in Genentech’s benefits package. Senior Principal Scientist Program: Senior Principal Scientist in Toxicology with 8+ years of industry experience. Responsibilities Scientific leadership in the design and implementation of safety assessment strategies to support program advancement and decision‑making. Preparation and review of regulatory documentation. Preparation and review of study reports and manuscripts. Representation of Genentech in meetings with regulatory authorities. Investigations into mechanisms of toxicity. Proactive management of potential safety liabilities and communication of impact to teams and governance committees. Mentoring and providing support to inter‑ and intra‑departmental initiatives. Qualifications PhD or equivalent in toxicology or a relevant field, with 8+ years of industry experience in toxicology. Extensive experience in drug development and interaction with global regulatory authorities. Experience in oncology and cardiovascular, respiratory, or metabolism therapy areas with modalities such as small molecules, degraders, and ADCs. Evidence of a consistent and extensive record of impact internally and externally. Strong decision‑making, complex problem solving, critical data analysis and interpretation skills. Excellent written and verbal communication skills and ability to build cross‑functional collaborations within and outside Genentech. Board certification in toxicology is desirable. Salary & Benefits The expected salary range is $171,110–$321,490 (primary location California). Actual pay will be determined based on experience, qualifications, geographic location, and other factors permitted by law. A discretionary annual bonus may be available. This position qualifies for benefits as detailed in Genentech’s benefits package. Location & Employment SanFrancisco, CA. Primarily onsite with relocation benefits available. Equal Opportunity Employer Genentech is an equal opportunity employer. We employ, promote, and otherwise treat all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of protected veteran status, disability status, and in accordance with all federal, state, and local laws. If you have a disability and need accommodation in the online application process, please complete the Accommodations for Applicants form. #J-18808-Ljbffr F. Hoffmann-La Roche AG