Postdoctoral Research Associate - Structural Biology

Postdoctoral Research Associate - Structural Biology Memphis, TN Postdoc Structural Biology Weekday Day Full Time 40 JR5310 Job Description A postdoctoral research associate position is available in the lab of Tanja Mittag in the Department of Structural Biology. Project Description: The Mittag laboratory invites applications for a Postdoctoral Research Associate Position to work on the biophysics of sequence–structure–function relationships of intrinsically disordered protein regions (IDRs). IDRs use different types of sequence-encoded grammars, and these are often tied to their subcellular localization and the biological processes they are involved in. We have extensively characterized how the molecular grammar of prion-like low-complexity domains encode conformational preferences and give rise to condensates with specific emergent properties (e.g., Martin et al. Science 2020, Bremer et al. Nat Chem 2022, Farag et al. Nat Commun 2023; Alshareedah et al. Nat Physics 2024; Posey et al JACS 2024). In this project, we will define sequence-encoded conformational preferences, driving force for phase separation and emergent properties of other types of IDR sequences. Position Responsibilities: The successful candidate will help shape the direction of the research and will use in vitro biophysical and biochemical studies to characterize the conformational properties of IDRs and the properties of the condensates they form. The candidate will interface with trainees and staff scientists in the Mittag lab, and with collaborators in a highly collaborative, interdisciplinary environment that will support their career development. Minimum Education and/or Training: The successful candidate should have a Ph.D. in biophysics or a related discipline. The candidate should demonstrate an academic record of excellence, and a strong interest in the growing field of biomolecular condensates. Special Skills, Knowledge, and Abilities: Experience with quantitative biophysical techniques such as NMR spectroscopy and/or small-angle X-ray scattering is required to capitalize on the opportunities of this project. About the lab and St. Jude: The successful candidate will join a highly collaborative laboratory focused on elucidating the biophysics, biochemistry and function of condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in the Department of Structural Biology and across the hospital. St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work,” and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture. We are in pursuit of the brightest minds in biomedical sciences, individuals poised to contribute to our research progress. Other than access to top-quality scientists and mentors, as a postdoctoral trainee at St. Jude, you will have: A Blend of Academic Freedom and Industrial Efficiency : Access to shared resources and facilities led by expert scientists, coupled with cutting-edge technology, accelerates research productivity. Customized Professional and Career Growth : Experience specifically designed programs to enhance professional growth and career readiness empowering postdocs for success beyond their training. This includes access to grant writing workshops, individual development plans, teaching and mentoring opportunities, non-research career advancement programs, professional development allowance, and so much more. Competitive Compensation : Embark on your journey with a competitive salary starting at $72,500 a year, comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent. A Sense of Community : St. Jude fosters a vibrant postdoc community that supports a well-balanced life. A dynamic environment promotes connections and camaraderie among postdocs from all backgrounds. 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