Associate Director, Quantitative Pharmacology & Pharmacometrics - Mechanistic Modeling, Immunology
$156.9k - $247kFull-time
Merck
Job Description The Associate Director is an expert mechanistic modeler and a quantitative drug developer who independently designs and executes model analysis plans with minimal supervision informing translational and drug development research questions within immunology.- The ideal candidate is collaborative, possesses a learning mindset and effectively partners with functional departments and external vendors to develop aligned strategies and deliver solutions.- In addition, you share your skills and ideas with the department to advance our science. Excellent communication skills are required including the ability to clearly present scientific data in group settings.-- As an Associate Director, you will participate in cross-functional teams of experienced scientists to discover and advance the clinical development of novel therapeutic agents for immunologic disorders. -You will apply your expertise to frame critical drug development questions to optimize drug development using model-based approaches and influence cross-functional teams to adopt such strategies. More specifically, you will apply your quantitative skills to integrate preclinical and clinical data developing and using PK/PD, PBPK, QSP, or other mechanistic models of drug disposition and drug action to define success criteria and make model-informed decisions. Moreover, you develop and implement translational PK/PD strategies, perform clinical trial simulations, conduct comparator modeling and other model-based analyses to inform dose selection and schedule, clinical trial design and go/no-go decisions.-- Required:
#EligibleforERP Required Skills:
Data Analysis, Data Modeling, Data Visualization, Drug Development, Immunology Research, Machine Learning (ML), Model Development, Pharmacology, Pharmacometrics, PKPD Modeling, Quantitative Models, Scientific Presentations Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is
$156,900.00 - $247,000.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
No Hazardous Material(s):
n/a Job Posting End Date:
10/24/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R419671
- Ph.D. or equivalent degree with at least 4 years of relevant experience; PharmD or equivalent degree with at least 6 years of relevant experience; or MS or equivalent degree with at least 8 years of relevant experience. Relevant experience should reflect increasing responsibility and independence in pharmaceutical drug development, a regulatory agency, or academia.
- An educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering.
- Experience in performing hands-on (population) PK / PKPD / QSP modeling using standard pharmacometric software (e.g. Phoenix, R, Matlab, NONMEM, Monolix)
- Advanced skills in experimental design, mathematical problem solving, critical thinking about data analysis and interpretation
- Proficiency in written and verbal communication and interdisciplinary collaboration
- An exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches
- Knowledge of immunology biology
- Experience with complex therapeutic biologics
- Expertise in developing novel modeling strategies or automated workflows that rely on PBPK, QSP or related mechanistic modeling
- Experience in integrating AI/ML methods in mechanistic modeling and/or modeling workflows
- Scientific understanding of ADME and biopharmaceutic properties of biologics, small molecules, or non-traditional therapeutics
#EligibleforERP Required Skills:
Data Analysis, Data Modeling, Data Visualization, Drug Development, Immunology Research, Machine Learning (ML), Model Development, Pharmacology, Pharmacometrics, PKPD Modeling, Quantitative Models, Scientific Presentations Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is
$156,900.00 - $247,000.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
No Hazardous Material(s):
n/a Job Posting End Date:
10/24/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R419671
Vacancy posted 2 days ago
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