Sr. Downstream Processing Technician

Downstream Processing Technician III

This role offers the opportunity to advance your manufacturing career by supporting large-scale biological and chemistry pharmaceutical operations in a state-of-the-art facility in St. Louis. As a Downstream Processing Technician III, you will work in cleanroom and aseptic suites to execute manufacturing batch records, work instructions, and standard operating procedures (SOPs) with a strong focus on accuracy and compliance. You will contribute directly to the production of biologics, such as large-scale proteins used in pharmaceutical products for conditions like autoimmune diseases, while upholding strict cGMP standards and collaborating closely with a team of experienced professionals.

Responsibilities include:

• Executing manufacturing batch records, work instructions, and SOPs with a proactive "right the first time" mindset to ensure consistent product quality.
• Assisting with batch record reconciliation to verify completeness, accuracy, and compliance with cGMP requirements.
• Supporting all department functions by maintaining production suites, supplies, equipment, logbooks, and data in accordance with site SOPs and policies.
• Documenting all activities accurately and in a timely manner to meet cGMP standards, including completing document reviews, revisions, and daily record reviews.
• Maintaining and updating tasks and databases as required, ensuring data integrity and traceability.
• Actively providing feedback on processes, documentation, and operations to support continuous improvement and lean initiatives.
• Participating in and, when needed, leading shift exchanges, one-on-one discussions, and team meetings to communicate changes, priorities, and area needs.
• Attending cross-functional meetings as required to facilitate smooth operations and address production or process changes.
• Supporting quality investigations by answering questions, providing detailed feedback, and suggesting improvements to prevent recurrence of issues.
• Practicing and promoting safe work habits at all times, strictly adhering to safety procedures, guidelines, and cleanroom protocols.
• Critically evaluating processes with foresight, identifying potential issues and opportunities for optimization before they impact operations.
• Interpreting production schedules and prioritizing tasks accordingly to ensure deadlines and production targets are met.
• Applying aseptic techniques and cleanroom practices to maintain product and environmental integrity during downstream processing.
• Collaborating with team members and subject matter experts on downstream processing steps to ensure consistent execution of procedures.
• Supporting training and knowledge sharing within the team by demonstrating best practices in documentation, aseptic technique, and cGMP compliance.

Work environment includes cleanroom and aseptic suites where you will support large-scale biological and chemistry pharmaceutical operations. You will work with biologics such as large-scale proteins that are used in pharmaceutical products. The environment follows strict cGMP, safety, and aseptic standards. You must be willing to fully gown up, including wearing a bodysuit, gloves, hair and beard nets, face covers, safety glasses, and other required protective equipment. Cleanroom gowning requirements include wearing Tyvek garments and nitrile and/or latex gloves. Certain personal items such as makeup, jewelry, nail polish, cologne or perfume, and scented lotions or hair care products are not permitted in the cleanroom. The training schedule runs Monday through Friday for 46 weeks, from 8:00 a.m. to 4:30 p.m. Following training, the position operates on a second-shift schedule from 1:00 p.m. to 11:30 p.m. with a rotating two-week pattern: Week 1 off Sunday, work MondayWednesday, off ThursdayFriday, work Saturday; Week 2 work Sunday, off MondayTuesday, work WednesdayFriday, off Saturday. The role requires the ability to lift at least 25 lbs independently and to stand for approximately 80% of the shift. You will work as part of a collaborative team in a structured, process-driven environment focused on quality, safety, and continuous improvement.

Job type and location: This is a contract to hire position based out of Saint Louis, MO.

Pay and benefits: The pay range for this position is $30.80/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: medical, dental & vision; critical illness, accident, and hospital; 401(k) retirement plan pre-tax and Roth post-tax contributions available; life insurance (voluntary life & AD&D for the employee and dependents); short and long-term disability; health spending account (HSA); transportation benefits; employee assistance program; time off/leave (PTO, vacation or sick leave).

Workplace type: This is a fully onsite position in Saint Louis, MO.

Application deadline: This position is anticipated to close on Jun 11, 2026.