Senior Program Manager

Job Description Senior Program Manager responsible for leading cross‑functional teams to develop and launch next‑generation sequencing (NGS)‑based products across Research Use Only (RUO), Laboratory Developed Tests (LDT), and In Vitro Diagnostics (IVD) applications, directly impacting patients with unmet clinical needs. Key Responsibilities Drive end‑to‑end program execution for NGS assay development from concept through commercialization. Align cross‑functional stakeholders (R&D, Operations, Quality, Regulatory, Marketing, Medical Affairs) on priorities, timelines, and deliverables. Manage program plans, timelines, resources, and dependencies across multiple sub‑projects. Partner with internal leadership and executive stakeholders to provide program updates and drive decision‑making. Lead collaboration with external partners to ensure delivery against contractual milestones. Identify, assess, and mitigate program risks; drive issue resolution and root cause analysis. Ensure timely completion of design history file (DHF) documentation and compliance with quality and regulatory requirements. Prepare teams for phase‑gate reviews and key go/no‑go decisions. Provide clear, concise program updates to core teams and executive leadership. Establish effective communication frameworks across cross‑functional teams. Navigate ambiguity and evolving priorities in a fast‑paced environment, demonstrating flexibility and sound judgment to adapt plans and drive programs forward. Basic Qualifications Bachelor’s degree in a technical or business‑related field. 5–8 years of program or project management experience (or 3–5 years with a master’s degree). Experience in FDA‑regulated environments. Demonstrated success leading cross‑functional teams in product development. Experience managing complex systems with multiple interdependent workstreams. Preferred Qualifications Experience in IVD, medical devices, or diagnostics product development. Experience with NGS assay development. PMP or equivalent certification. Familiarity with both Agile and Waterfall methodologies. Hybrid Work Model Employees eligible for hybrid work must be onsite on Mondays, Tuesdays, and Thursdays and may work from home on other days. This model supports both collaborative and focused work within the company’s policies. Compensation Annualized base salary ranges: Primary location (Palo Alto, CA) $169,500 – $233,100; Other U.S. locations $144,075 – $198,135; Colorado $152,550 – $209,790. The range does not include benefits or other compensation. Work Environment & Physical Requirements Employee may be required to lift routine office supplies, use office equipment, and sit for extended periods. The work is primarily desk/office based, with exposure to high noise levels, fumes, and biohazard materials in laboratory environments. Accommodations & Background Screening Guardant Health is committed to providing reasonable accommodations in hiring processes for candidates with disabilities, long‑term conditions, mental health conditions, or sincerely held religious beliefs. A criminal history background screening is required; qualified applicants with criminal arrest or conviction histories will be considered in accordance with applicable law. Equal Opportunity Employer Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. All your information will be kept confidential according to EEO guidelines. #J-18808-Ljbffr Guardant Health, Inc.