Principal Scientist, RNA Synthesis Process Sciences

Position Summary The Principal Scientist, RNA Synthesis Process Sciences plays a central role in collaborating with research and manufacturing teams to define early process conditions and scale‑down process development. This position provides scientific leadership for drug substance programs spanning preclinical to early stage development across circular and linear mRNA modalities, driving RNA drug substance synthesis and circularization strategies, influencing cross‑functional decisions, and delivering high‑impact outcomes across an increasingly diverse portfolio. Key Responsibilities Lead RNA synthesis process research for drug substance programs across a portfolio that may include circular RNA and mRNA, spanning preclinical to early‑stage development. Provide strategic oversight of reaction design, process development, and manufacturability, while contributing hands‑on scientific input where needed to resolve critical technical challenges. Apply high‑throughput, data‑driven approaches to assess and mitigate risks, defining mitigation strategies and making critical scientific recommendations at key program milestones. Represent drug substance development strategies in cross‑functional CMC teams, ensuring alignment across research, analytical development, engineering, regulatory affairs, and supply chain. Set clear priorities and objectives for Synthesis Process Sciences in alignment with portfolio goals and the broader organizational strategy. Mentor and develop scientists across the team, fostering an inclusive, high‑performance environment built on psychological safety, accountability, and collaboration. Propose and lead departmental initiatives that improve scientific workflows, sustainability practices, and operational efficiency. Build and maintain collaborative relationships with external academic institutions and industry partners to accelerate scientific advancement. Represent capabilities at internal reviews, scientific conferences, and in peer‑reviewed publications. Serve as a key scientific voice in cross‑functional CMC teams and broader enterprise forums. Collaborate with functional areas—including research, analytical development, engineering, and drug product development—to drive strategic alignment across the portfolio. Qualifications & Experience Degree in Bio/Chemical Engineering, Bio/Chemistry, or a related field with an MS and 8+ years of experience or a PhD with 3+ years of experience in science‑related disciplines. Expertise in in‑vitro transcription, enzymatic reactions, and innovative reaction unit‑operations. Expertise in high‑throughput experimentation and automation of upstream unit operations. Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data. Experience with process analytics and biophysical characterization techniques such as HPLC, CE, NGS, and gel electrophoresis. Experience working with CROs managing DNA supply and supporting DNA process troubleshooting related to RNA production. Knowledge of cGMP, ICH, regulatory guidelines, and QbD principles as they apply to risk management and clinical manufacturing. Exceptional written and oral communication skills, with the ability to convey complex scientific concepts clearly to both technical and non‑technical audiences. Ability to lead complex projects independently and influence decisions across matrixed teams and governance forums. Prior experience managing, mentoring, or developing scientists in an industrial setting. Demonstrated background in establishing early process definitions in preclinical to clinical manufacturing settings. Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus. Knowledge of establishing and qualifying scale‑down models and mechanistic models for process characterization is a plus. Compensation Overview Cambridge – MA – US: $153,660 – $186,203The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience. Benefits Health Coverage: Medical, pharmacy, dental, and vision care. Well‑being Support: BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work‑life benefits: Paid Time Off, flexible time off with manager approval, 11 paid national holidays, unpaid volunteer days, and a Global Shutdown. BristolMyersSquibb is an equal‑opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or any other protected status. #J-18808-Ljbffr Bristol-Myers Squibb