Principal Scientist, LNP Process Development & MS&T Cambridge - MA - US R1603856 Posted a day ago
$153.66k - $186.2kBristol-Myers Squibb
- # Principal Scientist, LNP Process Development & MS&TCambridge - MA - USFind out how well you match with this job**Working with Us** Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.The Principal Scientist, LNP Process Development & MS&T plays a central role in enabling the success of batches in clinical development across multiple products. Connecting with both the larger LNP PD team and with research to develop clinical scale batches that are representative across scales and sites.The Principal Scientist is a scientific leader responsible for driving clinical manufacturing strategy, influencing cross-functional decisions, and delivering high-impact outcomes across an increasingly diverse portfolio. **Position Summary** The Principal Scientist provides scientific leadership for bulk drug product programs spanning preclinical to early-stage development and leading the tech transfer and implementation of process into clinical production. This role is primarily focused on hands-on scientific contribution by driving sound experimental execution and establishing the linkage from small scale process to manufacturing implementation at scale in a GMP environment. **Key Responsibilities** Scientific Leadership* Lead the tech transfer from nonclinical production and development to a clinical production site, interfacing with site leadership to ensure clinical production success.* Provide strategic oversight of process development and manufacturability, while contributing hands-on scientific input where needed to resolve critical technical challenges.* Apply high throughput data drive approaches to assess and mitigate risks, defining mitigation strategies and making critical scientific recommendations at key program milestones* Represent bulk drug product development strategies in cross-functional CMC teams, ensuring alignment across research, analytical development, engineering, regulatory affairs, and supply chainPeople Leadership & Talent Development* Set clear priorities and objectives for LNP PD MSAT in alignment with portfolio goals and LNP PD’s broader organizational strategy* Mentor and develop scientists across LNP PD MSAT, contributing to a culture of scientific excellence and continuous learning* Foster an inclusive, high-performance team environment built on psychological safety, accountability, and collaborationInnovation & Organizational Contribution* Propose and lead departmental initiatives that improve scientific workflows, sustainability practices, and operational efficiency* Build and maintain collaborative relationships with external academic institutions and industry partners to accelerate scientific advancement* Represent capabilities at internal reviews, scientific conferences, and through peer-reviewed publicationsCross-Functional Collaboration* Serve as a key scientific voice in cross-functional CMC teams and broader enterprise forums* Partner with functional areas - including research, analytical development, engineering, and drug substance development* Collaborate with organization leadership to drive strategic alignment across the portfolio**Qualifications & Experience*** Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field MS with 8+ years’ or PhD with 3+ years’ experience in science related disciplines* Expertise with lipid nanoparticle formation, conjugation reactions, and tangential flow filtration unit operations* Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data* Experience with performing and interpreting process analytics and biophysical characterization techniques such as DLS and Encapsulation Efficiency* Experience working with both internal and external clinical manufacturing sites* Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing* Exceptional written and oral communication skills, with the ability to convey complex scientific concepts clearly to both technical and non-technical audiences* Ability to lead complex projects independently and influence decisions across matrixed teams and governance forums.* Prior experience managing, mentoring, or developing scientists in an industrial setting* Demonstrated background working in a GMP environment and supporting change controls, developing clinical strategies, and resolving deviations in conjunction with Quality teams* Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus* Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus* May require international travel*If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.*******Compensation Overview:******Cambridge - MA - US: $153,660 - $186,203 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:* **Health Coverage:** Medical, pharmacy, dental, and vision care.* **Wellbeing Support:** Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).* **Financial Well-being and Protection:** 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.**Work-life benefits include:**Paid Time Off* US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)* Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidaysBased on eligibility\*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.***\*Eligibility Disclosure:** *T*he summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.***Uniquely Interesting Work, Life-changing Careers** With a single vision as inspiring as “Transforming patients’ lives through scienceTM ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.**On-site Protocol**BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.**Supporting People with Disabilities**BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to View email address on click.appcast.io. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.**Candidate Rights**BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Protection**We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at View email address on click.appcast.io. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.R1603856 : Principal Scientist, LNP Process Development & MS&T
- J-18808-Ljbffr Bristol-Myers Squibb
Vacancy posted 1 day ago
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