Senior Scientist, Antibody Discovery

Job Description Merck & Co., Inc. (Merck Sharp & Dohme LLC) is a leading biopharmaceutical company dedicated to turning breakthrough science into life‑changing medicines. We are seeking a highly motivated, energetic Senior Scientist to join the Discovery Biologics team in South San Francisco. This hands‑on, lab‑facing role focuses on antibody discovery using in vivo immunization, single‑cell antibody discovery platforms, and the 10x Genomics workflow. The successful candidate will design and execute high‑throughput discovery strategies, collaborate across multidisciplinary teams, and help deliver high‑quality antibody candidates on accelerated timelines. Key Responsibilities Design, execute, and lead antibody discovery campaigns using single‑B‑cell discovery workflows. Identify and implement opportunities to reduce timelines, improve throughput, and increase operational efficiency. Represent the antibody discovery group on multidisciplinary project teams and provide scientific leadership on discovery strategy, screening plans, and candidate progression. Stay current with emerging scientific and technological advances relevant to antibody discovery and single‑cell platforms. Contribute to the external scientific visibility of the Discovery Biologics team through publications, presentations, and scientific engagement. Qualifications Education: Bachelor’s (with 7+ years), Master’s (with 4+ years) or Ph.D. in Biology, Biochemistry or related discipline and relevant experience. Strong technical expertise with the 10x Genomics Single Cell 5′ V(D)J workflow for antigen‑specific antibody isolation, including sample preparation, B‑cell sorting, and library generation. Hands‑on laboratory skills in cell culture, molecular biology, high‑throughput screening, assay development, and flow cytometry. Significant experience in antibody discovery, specifically in vivo immunization‑based discovery approaches using single B‑cell screening and sequencing. Excellent communication, collaboration, and cross‑functional partnership skills. Demonstrated ability to manage multiple projects and competing priorities while maintaining scientific rigor and attention to detail. Proven success working in a fast‑paced, deadline‑driven environment. Highly motivated and collaborative scientist with a strong sense of ownership, urgency, and adaptability. Established external reputation through publications, presentations, and/or scientific community engagement. Champion for a diverse and inclusive culture. Preferred Experience and Skills Experience with next‑generation sequencing approaches and related data interpretation in antibody discovery workflows, including 10x Genomics data. Experience managing antibody discovery campaigns. Location and Compensation Location: South San Francisco, CA. Salary range: $131,400.00 – $206,800.00 (at time of posting). Annual bonus and long‑term incentive eligibility, if applicable. Benefits Medical, dental, vision, and other insurance benefits for employee and family. Retirement benefits, including 401(k). Paid holidays, vacation, compassionate and sick days. Comprehensive benefits package. Equal Employment Opportunity Statement As an Equal Employment Opportunity Employer, Merck provides equal opportunities to all employees and applicants for employment and prohibits discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. #J-18808-Ljbffr MSD Malaysia