Founding Engineer, Applied Research
Backbone Systems
Founding Engineer, Applied Research About Backbone Care should be paid for the moment it’s delivered. At Backbone, we’re making that possible for the first time by building the clinical AI layer for healthcare payments. Today, U.S. healthcare wastes more than $350B yearly on administrative work that has nothing to do with patient care: prior authorizations, denials, appeals, and the staff hired on both sides of the aisle to adjudicate and determine payment for services rendered. As a result, patient care is delayed, clinicians burn out, margins crater, and hundreds of billions of dollars that should be funding care end up funding the friction itself. Backbone is dismantling this friction, building intelligent financial rails atop clinical AI research to facilitate instant payments between payers and providers. We're backed by Andreessen Horowitz (a16z), Lightspeed, Hanabi, and a roster of operators and clinicians who have built and run the largest payers, providers, and healthcare technology platforms in the country. Our founder/CEO, Manan Shah, holds a BS/MS in Math & CS from Stanford and led ML infrastructure at Sequoia-backed Kumo AI, where he built graph neural networks serving DoorDash, Reddit, and Coinbase. Backbone’s revenue is growing quickly, customer demand is outpacing our team, and the road ahead is bright. What you’ll do We’re solving applied research problems in clinical intelligence. Backbone’s core systems, based on post-trained open-weights models and systems of closed-weights models, read charts, claims, denials, appeals, clinical criteria, payer policies, and quality metrics, then make accurate, defensible decisions in production. We also leverage continually improving browser-use and computer-use models to navigate payer portals, EHRs, practice management systems, and the messy software layer that healthcare runs on. This is not a pure research role. Alongside core model improvements, you’ll take ambiguous research problems, turn them into evals, improve model behavior, and work with engineers to put those improvements into production. You will: Build evals for clinical reasoning, chart understanding, claims review, authorization logic, denial analysis, appeal generation, and payer policy interpretation Improve Backbone’s ability to read and reason over real clinical and financial data, with work across model behavior, prompting, fine-tuning, retrieval, structured reasoning, verification, and evaluation Build and improve agentic browser-use and computer-use capabilities for payer portals and healthcare software Translate product feedback from live provider and payer workflows into research problems, partnering with backend engineers to productionize research improvements What we’re looking for New grad through ~5-6 years of experience, with experience with ML research, language models, NLP, evals, reinforcement learning, agentic systems, or model improvement Clear evidence of technical depth through papers, projects, internships, open-source work, competitions, or production ML systems. Infrastructure or systems experience is a major plus. Excitement about building applied research systems where the output touches real workflows, real dollars, and real patient impact. Healthcare experience is helpful, but not required. Curiosity, rigor, and taste matter more. Why join This is a chance to join early and help define both the product and the engineering culture. You’ll work on hard, practical problems: turning fragmented healthcare workflows into software that actually helps people do their jobs faster and better. Your work will touch product decisions, system architecture, user experience, and the core automation engine behind Backbone. We offer competitive compensation, meaningful ownership, and the opportunity to build foundational technology in a massive, broken, high-impact industry. #J-18808-Ljbffr Backbone Systems
- Hebbia AI is looking for an Applied Research Engineer to bridge research and application in natural language processing systems. This role involves defining cutting-edge solutions and collaborating with teams to enhance products using advanced LLM techniques. The ideal...Suggested
$120k - $200k
...Join to apply for the Founding Engineer - Full Stack role at Andy AI (W24) Join to apply for the Founding Engineer - Full Stack role at Andy AI (W24) This range is provided by Andy AI (W24). Your actual pay will be based on your skills and experience — talk...SuggestedFull time$160k - $270k
...As a member of our Forward Deployed Engineering Team, you will partner directly with our... ...enterprise AI implementations and be among our founding FDEs who establish our forward‑deployed... ...founders are strongly encouraged to apply ~ Production LLM experience including...SuggestedHome officeFlexible hours3 days per week- ...An early-stage AI startup in San Francisco is seeking a Founding Engineer to help architect and build their platform from scratch. This role... ...a fast-paced environment and tackle ambiguity. Interested applicants are encouraged to apply confidentially. #J-18808-Ljbffr...Suggested
$175k - $200k
...stage, Y Combinator-backed AI marketing automation startup as a Founding Engineer (Full-Stack). You'll be one of the first engineers on the... ...Inngest; maintain dedicated deployments on Microsoft Azure Apply user-centric design thinking across the full product lifecycle...SuggestedFull timeWork at officeRelocationVisa sponsorshipRelocation package$130k - $160k
...Job Description Founding Engineer (AI / Full Stack) San Francisco, USA (Relocation + Visa Sponsorship) $130,000 - $160,000 + Equity... ...re a top-tier engineer looking for a founding role in Silicon Valley, apply or reach out directly for a confidential discussion.Work at officeRelocationVisa sponsorship$130k - $200k
...Founding Engineer (Frontend) Title of Role: Founding Engineer (Frontend) Location: San Francisco, onsite Company Stage of Funding... ...satisfaction. Stay updated on emerging technologies and apply them to improve the product. Ideal Candidate Background...Work at officeLocal area- ...interesting technical challenge – our engineering team focuses on reverse engineering the... ..., push the boundary on a new field of research – applied interpretability, and make a positive... ...love to talk. About The Role As a Founding Engineer, you'll own problems end-to-...
$200k
...market investing. As a Senior Software Engineer on Meridian, you’ll own the technical design... ...through launch and iteration. This is a founding engineer role on a zero-to-one product... ...requirement above, we still encourage you to apply. We value complementary strengths and...Work at office2 days per week£60k - £120k per year
...Location Type On-site Department Engineering Compensation £60K - £120K •... ...industry veterans... Our research has recently helped fix a P1... ...a difference here - please, apply! About the role Reporting to... ...great cadence to work. As a Founding Engineer there will definitely...Full timeWork at officeRemote workWork from homeRelocationVisa sponsorshipWork visaRelocation packageFree visaSkilled worker visaFlexible hours- ...TierZero’s mission is to accelerate software engineering. Today, engineers spend 50-70% of... ...be reclaimed. Highlights Team : Our founding team is made up of pioneers in AI... ...regularly. We blend hardcore engineering with applied research to solve real, unsolved problems. You...Work at office3 days per week
$145k - $195k
The Role We’re hiring our first Founding Engineer — someone who will work alongside the founder... ...and turning peer-reviewed cryptographic research into production software that enterprises... ..., FIDO2, WebAuthn), key management, or applied cryptography is a strong signal....Work at office$170k - $220k
...Founder is Sahil Manocha who’s a published researcher and has previously built ad... ...relevant ads at the right moment. Role Founding engineer who’ll help us design the engine for ad... ...in a fun and social work environment Apply and you’ll hear back in less than a day...$160k - $200k
Founding Engineer — Wildcard Location: San Francisco, CA (Onsite) Compensation: $160,000 - $200,000 base + competitive founding equity Visa... ...Logistics Role is fully onsite in San Francisco — please only apply if you can commit to this No visa sponsorship available Shortlisted...Full time$150k - $250k
Founding GTM Engineer — Conversion AI Location: San Francisco, CA (Onsite, 5 days/week) Compensation: $150,000 - $250,000 base + equity Employment... ...fully onsite in San Francisco — 5 days/week — please only apply if you can commit to this Shortlisted candidates will be...Full time$200k
Job Title Founding Engineer - AI Salary $200k+ + Equity Company Description SF-based AI construction startup backed by top-tier VCs who invested... ...technical experience with a proven track record of shipping applied AI, computer vision, or LLM-based products to real users....For contractors- ...employees. Our agents execute product, design, and engineering processes. You will be building and deploying the... ...Machine Learning from Stanford, Berkeley, and CMU, with applied research at Google Brain, Waymo, and co-founded Coursera. The Job You will own features end-to-...Work at office
$140k - $220k
...clinician workflows that make great care feel effortless Role: Founding Engineer - AI‑Native Mental Health Care (In‑Person in SF) I’m hiring a... ...characteristic under applicable law. We encourage applicants from all backgrounds to apply. #J-18808-Ljbffr Legion HealthFull timeFor contractorsLive inVisa sponsorshipFlexible hours$180k - $220k
Job Title Founding Engineer Salary $180K-220K + Equity Company Corveris - a public safety startup backed by South Park Commons. Location... ...environments. Expert-level proficiency with modern web stacks and applied ML technologies like vector databases and embeddings. A...Immediate start- ...leaders behind Amazon, Facebook, Stripe, Applied Intuition, & others; General Catalyst & Neo... ...Dryft is powering the next. THE ROLE As Founding Product Operations Lead , you’ll operate at the intersection of product, engineering, and operations — turning complex manufacturing...
$175k - $250k
Founding Engineer — Empathic Location: San Francisco, CA (100% Onsite) Compensation: $175,000 - $250,000 base + 1% - 6% equity Employment Type... ...Role is 100% onsite in San Francisco — please only apply if you can commit to this Shortlisted candidates will be contacted...Full time- ...building the first truly functional personal agent powered by applied AI. As a Founding Engineer, you'll work directly with our core team to establish... ..., and security across our systems Collaborate with AI researchers to implement cutting-edge agent capabilities Help...
- tl;dr: Interface is looking for generalist founding engineers (ml, data, full-stack) who are scrappy, push boundaries and have a need to win.... ...great weather and best tech ecosystem in the world other stuff Apply from anywhere in the world. Competitive pay, strong equity,...Work at office
- As a founding member of our engineering team, you’ll play a pivotal role in building the data and evaluation... ...ambiguous requirements, conduct research, analyze trade‑offs, and own project... ...‑growth companies. Experience with applied AI / AI research - specifically in post...Immediate start
$200k - $300k
...a quickly growing group of committed researchers, engineers, policy experts, and business leaders... ...systems. About The Role As a member of the Applied AI team at Anthropic, you will be a... ...AI deployments and serve as one of our founding FDEs who helps to shape our forward‑...Work at officeVisa sponsorshipFlexible hours- ...top-tier investors, and are founded by Keegan McCallum, who scaled... ...that model labs, builders, and research teams ship on top of. Where... ...quo. As our ML Performance Engineer, you will be the person who makes... ...you know that before you apply. Watch our launch party video...Flexible hoursShift work
- About Hyperscale Founding Sales Engineer (SF In-Person Preferred) Hyperscale is building the AI-native intelligence layer for physical operations... ...role is for you. You'll be working on the frontier of applied AI deployment: taking sophisticated agentic systems from demo...Immediate startFlexible hours
- ...aerospace, and industrial manufacturers. Engineering Agent Workflows Design and implement... ...the Role We’re hiring a world-class Applied AI Engineer to build the core systems... ...with LLM architectures and agent research trends Excellent programming skills with...Permanent employmentH1bRemote workRelocationVisa sponsorship
$150k - $250k
OVERVIEW: ROLE : Founding Robotics Engineer ROLE TYPE : Direct Hire COMPENSATION : $150,000 - $250,0... ...real-world data , not simulation-only research Broad technical scope spanning robotics... ...-stage company can offer. HOW TO APPLY: If you are a motivated and organized...Permanent employmentH1bWork at officeLocal areaImmediate startRelocationFlexible hours$150k - $250k
...As our Founding Security Reliability Engineer at Charta Health, you'll pioneer the application of Site Reliability... ...'s security architecture by applying SRE principles: ensuring robust security... ...advancements. Continuously research and integrate the latest security technologies...
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Founding Engineer, Applied Research. Be the first to apply!
- anthropology research San Francisco, CA
- research dietitian San Francisco, CA
- history research San Francisco, CA
- education policy research San Francisco, CA
- research pharmacist San Francisco, CA
- research professional San Francisco, CA
- student research intern San Francisco, CA
- research intern San Francisco, CA
- physics research San Francisco, CA
- pharmaceutical research San Francisco, CA

