Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Founding Engineer, Applied Research

Backbone Systems

Founding Engineer, Applied Research About Backbone Care should be paid for the moment it’s delivered. At Backbone, we’re making that possible for the first time by building the clinical AI layer for healthcare payments. Today, U.S. healthcare wastes more than $350B yearly on administrative work that has nothing to do with patient care: prior authorizations, denials, appeals, and the staff hired on both sides of the aisle to adjudicate and determine payment for services rendered. As a result, patient care is delayed, clinicians burn out, margins crater, and hundreds of billions of dollars that should be funding care end up funding the friction itself. Backbone is dismantling this friction, building intelligent financial rails atop clinical AI research to facilitate instant payments between payers and providers. We're backed by Andreessen Horowitz (a16z), Lightspeed, Hanabi, and a roster of operators and clinicians who have built and run the largest payers, providers, and healthcare technology platforms in the country. Our founder/CEO, Manan Shah, holds a BS/MS in Math & CS from Stanford and led ML infrastructure at Sequoia-backed Kumo AI, where he built graph neural networks serving DoorDash, Reddit, and Coinbase. Backbone’s revenue is growing quickly, customer demand is outpacing our team, and the road ahead is bright. What you’ll do We’re solving applied research problems in clinical intelligence. Backbone’s core systems, based on post-trained open-weights models and systems of closed-weights models, read charts, claims, denials, appeals, clinical criteria, payer policies, and quality metrics, then make accurate, defensible decisions in production. We also leverage continually improving browser-use and computer-use models to navigate payer portals, EHRs, practice management systems, and the messy software layer that healthcare runs on. This is not a pure research role. Alongside core model improvements, you’ll take ambiguous research problems, turn them into evals, improve model behavior, and work with engineers to put those improvements into production. You will: Build evals for clinical reasoning, chart understanding, claims review, authorization logic, denial analysis, appeal generation, and payer policy interpretation Improve Backbone’s ability to read and reason over real clinical and financial data, with work across model behavior, prompting, fine-tuning, retrieval, structured reasoning, verification, and evaluation Build and improve agentic browser-use and computer-use capabilities for payer portals and healthcare software Translate product feedback from live provider and payer workflows into research problems, partnering with backend engineers to productionize research improvements What we’re looking for New grad through ~5-6 years of experience, with experience with ML research, language models, NLP, evals, reinforcement learning, agentic systems, or model improvement Clear evidence of technical depth through papers, projects, internships, open-source work, competitions, or production ML systems. Infrastructure or systems experience is a major plus. Excitement about building applied research systems where the output touches real workflows, real dollars, and real patient impact. Healthcare experience is helpful, but not required. Curiosity, rigor, and taste matter more. Why join This is a chance to join early and help define both the product and the engineering culture. You’ll work on hard, practical problems: turning fragmented healthcare workflows into software that actually helps people do their jobs faster and better. Your work will touch product decisions, system architecture, user experience, and the core automation engine behind Backbone. We offer competitive compensation, meaningful ownership, and the opportunity to build foundational technology in a massive, broken, high-impact industry. #J-18808-Ljbffr Backbone Systems

Vacancy posted 18 hours ago
Similar jobs that could be interesting for youBased on the Founding Engineer, Applied Research in San Francisco, CA vacancy
  •  ...clinical AI layer for healthcare payments. We’re solving applied research problems in clinical intelligence, reading charts, denials...  ...support instant, defensible decisions in production. As a Founding Engineer, Applied Research in San Francisco, you’ll turn ambiguous... 
    Suggested
    Remote work

    backbone uk - secure remote working solutions to small & mid...

    San Francisco, CA
    18 hours ago
  • $180k - $250k

     ...startup building AI for hardware engineering at complex manufacturers —...  ...top-tier venture firms. The founding team spans AI, advanced engineering...  ...client is hiring a Founding Applied AI Engineer to build the core...  ...LLM architectures and agent research trends ~ A Bachelor's or... 
    Suggested
    Full time
    H1b
    Remote work
    Visa sponsorship

    David Joseph & Company

    San Francisco, CA
    22 days ago
  • $120k - $180k

     ...cost estimation — making construction faster and more affordable. As a Founding Engineer (Applied AI) , you'll own the intelligence layer: advancing computer vision and AI systems from research to production prototypes that real users rely on every day. This is a... 
    Suggested
    Permanent employment
    Full time
    Work at office
    Remote work
    Relocation

    Clera

    San Francisco, CA
    3 days ago
  • $250k

     ...Founding Engineer (San Francisco Startups | up to $250k+ + equity) Salary: Total compensation up to $250,000+ plus meaningful equity Dex is...  ...roles we show you have already passed the filter you'd want to apply yourself. The opportunities Compensation at these companies... 
    Suggested

    DEX

    San Francisco, CA
    2 days ago
  • $200k

     ...private market investing. As a Senior Software Engineer on Meridian, you’ll own the technical...  ...through launch and iteration. This is a founding engineer role on a zero‑to‑one product...  ...requirement above, we still encourage you to apply. We value complementary strengths and... 
    Suggested
    Work at office
    2 days per week

    AngelList Venture

    San Francisco, CA
    4 days ago
  • $120k - $200k

     ...project‑specific codes and standards, precedent research, and coordinated AI agents to produce...  ...K, 1.00% – 2.00% equity. About The Role As a Founding Engineer, you will work directly with the founders on difficult applied‑AI and distributed‑systems problems that sit... 
    For contractors
    Local area

    Red Cedar Ventures

    San Francisco, CA
    3 days ago
  •  ...tl;dr: Interface is looking for generalist founding engineers (ml, data, full-stack) who are scrappy, push boundaries and have a need to win...  ...great weather and best tech ecosystem in the world other stuff Apply from anywhere in the world. Competitive pay, strong equity,... 
    Work at office

    Interface

    San Francisco, CA
    5 days ago
  •  ...is Varun Jampani, a leading researcher who co-authored Dreambooth and...  .... The Role This is a founding growth role, and it is not a...  ...ll treat go-to-market as an engineering problem, building scalable,...  ...background in data science, applied math, physics, CS, or a similarly... 

    Arcade Studio Inc

    San Francisco, CA
    2 days ago
  •  ...Backed by Y Combinator ABOUT THE ROLE We are hiring a Founding Sales Engineer to help enterprise customers successfully adopt Voice AI...  ...intersection of sales engineering, solution architecture, applied AI, and enterprise software. You'll work directly with some... 
    H1b

    Retell AI

    San Francisco, CA
    3 days ago
  • $120k - $200k

    Join to apply for the Founding Engineer - Healthcare AI role at Andy AI (W24) Join to apply for the Founding Engineer - Healthcare AI role at Andy AI (W24) Get AI-powered advice on this job and more exclusive features. This range is provided by Andy AI (W24). Your actual... 
    Full time

    Andy AI (W24)

    San Francisco, CA
    2 days ago
  • $170k - $220k

     ...Founder is Sahil Manocha who’s a published researcher and has previously built ad...  ...relevant ads at the right moment. Role Founding engineer who’ll help us design the engine for ad...  ...in a fun and social work environment Apply and you’ll hear back in less than a day... 

    Pear VC

    San Francisco, CA
    1 day ago
  • As a founding member of our engineering team, you’ll play a pivotal role in building the data and evaluation...  ...ambiguous requirements, conduct research, analyze trade‑offs, and own project...  ...‑growth companies. Experience with applied AI / AI research - specifically in post... 
    Immediate start

    MangoDesk (YC S25)

    San Francisco, CA
    1 day ago
  • $120k - $200k

    Join to apply for the Founding Engineer - Full Stack role at Andy AI (W24) Join to apply for the Founding Engineer - Full Stack role at Andy AI (W24) This range is provided by Andy AI (W24). Your actual pay will be based on your skills and experience — talk with your recruiter... 
    Full time

    Andy AI (W24)

    San Francisco, CA
    2 days ago
  • $13 per hour

     ...high-growth companies stay private longer. We are looking for a founding engineer on our new Capital Products Team. This team is building new...  ...opportunities posted for specific teams, so please just apply to one. The team will consider you for all open roles that could... 
    Full time
    Work at office

    AngelList

    San Francisco, CA
    5 days ago
  • $240k - $400k

     ...real‑world guarantees. Join a talent‑dense founding team with meaningful equity and real...  ...intelligence. Role Summary As our Founding Engineer, you will own a zero‑to‑one product and...  ...on use of AI tools with clear ideas for applying AI to development, testing, data, and... 
    Visa sponsorship

    Praxis, Inc.

    San Francisco, CA
    18 hours ago
  •  ...website into your company's main growth engine. We deploy swarms of marketing and web design...  ...infrastructure of a growth team. Ploy is founded by Bryant Chou, the co‑founder and former...  ...exactly but think you'd be great here, apply anyway. We read everything. #J-18808-... 

    Ploy

    San Francisco, CA
    1 day ago
  • Founding Engineer We are building the system of record for AI-native knowledge work. Nessie auto-syncs AI conversations across every major provider...  ...from week 4. That should excite you, not stress you. How to apply Show us something you built. A link to a project, a repo, a... 

    Nessie Labs, Inc

    San Francisco, CA
    2 days ago
  • $250k - $400k

    foam — Founding Engineer Type : Full-time | On-site | San Francisco, CA Compensation : $250,000-$400,000 + 0.25%-2% equity Hiring count : 1...  ...housing near office, $10,000 misc. 24‑month repayment agreement applies Employment type: Full-time Location: San Francisco, CA... 
    Full time
    Temporary work
    H1b
    Work at office
    Relocation
    Visa sponsorship

    davidjoseph-co

    San Francisco, CA
    18 hours ago
  •  ...AI is a San Francisco-based tech company founded in 2022. We provide a Delivery Intelligence...  ...The Role We are looking for a Founding Engineer with 4+ years of backend engineering experience...  .... Critical Thinking & Problem Solving: Apply first‑principles thinking to solve... 
    Temporary work

    Loop AI - Delivery Intelligence Platform

    San Francisco, CA
    3 days ago
  • An early-stage AI startup in San Francisco is seeking a Founding Engineer to help architect and build their platform from scratch. This role...  ...fast-paced environment and tackle ambiguity. Interested applicants are encouraged to apply confidentially. #J-18808-Ljbffr XUMAN.AI

    XUMAN.AI

    San Francisco, CA
    18 hours ago
  •  ...TierZero’s mission is to accelerate software engineering. Today, engineers spend 50-70% of...  ...be reclaimed. Highlights Team : Our founding team is made up of pioneers in AI...  ...regularly. We blend hardcore engineering with applied research to solve real, unsolved problems. You... 
    Work at office
    3 days per week

    Embedding VC

    San Francisco, CA
    1 day ago
  •  ...aerospace, and industrial manufacturers. Engineering Agent Workflows Design and implement...  ...the Role We’re hiring a world-class Applied AI Engineer to build the core systems...  ...with LLM architectures and agent research trends Excellent programming skills with... 
    Permanent employment
    H1b
    Remote work
    Relocation
    Visa sponsorship

    Product Pulse

    San Francisco, CA
    21 hours ago
  • $130k - $200k

    Join us to apply for the Founding Engineer (Systems + ML) role at Partcl . Get AI-powered advice on this job and more exclusive features. This range is provided by Partcl. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more... 
    Full time

    Partcl

    San Francisco, CA
    3 days ago
  • $150k - $220k

     ...the decisions it makes, and we need a founding engineer to own that intelligence. As a Founding...  ...own decision quality end-to-end, from research bench to production. Compensation range...  ...and set the example for what world-class applied AI looks like here. What you'll bring... 

    Optimized, Inc.

    San Francisco, CA
    3 days ago
  • $500 per month

     ...DESCRIPTIONThis company handles millions of calls per month and needs an engineer who has worked at that scale before and knows how to build...  ...sub-100 milliseconds.You will work on-site directly with the founding team, contributing across architecture, infrastructure, and... 
    H1b

    Affinity Executive Search

    San Francisco, CA
    1 day ago
  • Socket.dev is seeking a founding Mechanical Engineer to own the design and integration of a reusable reentry vehicle for Dispatch, from CAD to qualification...  ...-stage hardware. You’ll work daily with the founders, applying your strong CAD and FEA skills to develop robust flight... 

    Socket.dev

    San Francisco, CA
    1 day ago
  • Career Launch is seeking an India Founding Engineer (Computer Vision) who can move quickly in ambiguous...  ..., and solid analytical judgment across research, prototyping, and production. This...  ...Career Launch opportunities. Please apply with your resume and context to help recruiting... 

    Career-Launch.net

    San Francisco, CA
    2 days ago
  • Salesforce, Inc. is seeking an Applied Research Engineer to join their AI team in San Francisco. This role involves building and deploying the next generation of AI-enabled services while working closely with research scientists. You will be responsible for designing and... 

    Salesforce, Inc.

    San Francisco, CA
    18 hours ago
  • $180k - $225k

     ...models, reasoning techniques, agent architectures, and research papers emerge every week. Yet building AI systems...  ...real-world problems remains one of the hardest engineering challenges.As a Frontier Agent Engineer (Applied AI), you'll bridge the gap between cutting-edge AI... 
    Full time

    Scale AI

    San Francisco, CA
    3 days ago
  • $120k - $180k

     ...more cost-efficient. About the Role We’re hiring a Full Stack Engineer to build and scale end-to-end web applications across our platform...  ...role sits at the intersection of product, infrastructure, and applied AI, working closely with a small, fast-moving team to ship... 
    Internship
    Flexible hours

    Vector Legal

    San Francisco, CA
    4 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Founding Engineer, Applied Research. Be the first to apply!