Principal Scientist
$185k - $215kOneDigital NorCal HR Consulting
OneDigital NorCal HR Consulting provided pay range This range is provided by OneDigital NorCal HR Consulting. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range $185,000.00/yr - $215,000.00/yr **Posting for our client, Isotovia Biosciences ** We are looking for an outstanding Principal Scientist to join our Discovery team at Isotovia Biosciences, a new company in San Carlos. This individual will be a part of an integrated highly motivated team developing Attobody-based therapeutic molecules. As a vital member, the successful candidate will play a key role in building the foundation of the company’s Discovery organization. This is an on-site position. Key Responsibilities: Responsible for Attobody discovery campaign using yeast and phage display technology, including design, execution and troubleshooting. Perform hands-on Attobody discovery workflow, from library construction, library panning, output screening, single clone attobody characterization and data analysis. Antibody characterization includes affinity and specificity determination, epitope binning and cell binding. Document and maintain ELN (Benchling) with accuracy in a timely manner Oversee outside vendors in matters related to protein production and characterization Conduct in-depth data analysis, communicate data efficiently in project meetings in line with project timeline and goals. Evaluate and assess new technologies and processes that could improve and streamline the discovery workflow. Analyze and interpret data, identify problems, and develop troubleshooting strategies. Proactively review scientific literature and provide strategic input and generate ideas for project Assesses the needs of a technology platform or Isotovia program and coordinates activities over multiple functions to fulfill company objectives and program goals. Performs other duties as assigned Basic Qualifications: Master’s degree in biology or related field with a minimum of 10 plus years' experience in antibody discovery OR a PhD in Biology or related field with a minimum of 8 years' experience in antibody discovery Demonstrated ability to use and design in vitro antibody discovery display technologies (e.g., phage, yeast display) for discovery and/or engineering Sanger sequence analysis experience Excellent organizational skills and the ability to manage multiple projects simultaneously Demonstrated productivity and scientific independence with strong problem-solving skills. Desire to work in a dynamic startup environment is essential. Preferred Qualifications: Strong communication skills to work within a multidisciplinary team environment. Direct experience with Carterra LSA, Biacore SPR, Octet BLI and flow cytometry (iQUE) Experience with robotic liquid handling systems is a plus. Knowledgeable in recombinant protein production and characterization Proficiency in GraphPad Prism, Geneious and Benchling Demonstrated track record in managing multiple projects and prioritizing tasks to meet schedules and timelines. Excellent written and oral communication skills and the ability to present effectively to teams. Proven contribution to therapeutic antibody development and selection is desirable. Salary range: $185,000-$215,000. The final salary offered is dependent on factors that may include but are not limited to the type and length of experience within the industry, education, etc. Seniority level Seniority level Mid-Senior level Employment type Employment type Full-time Job function Job function Science Referrals increase your chances of interviewing at OneDigital NorCal HR Consulting by 2x Get notified about new Scientist jobs in San Carlos, CA . Foster City, CA $135,000.00-$185,000.00 1 week ago Hayward, CA $125,000.00-$150,000.00 3 weeks ago Fremont, CA $110,000.00-$115,000.00 4 weeks ago Scientist / Sr. Scientist, Medical Hibernation San Francisco, CA $120,000.00-$180,000.00 2 days ago San Francisco Bay Area $100,000.00-$150,000.00 2 weeks ago San Francisco Bay Area $116,000.00-$145,000.00 2 weeks ago South San Francisco, CA $57,574.40-$110,635.20 6 days ago Scientist I/II/Senior Scientist, Medicinal Chemistry Menlo Park, CA $120,000.00-$180,000.00 14 hours ago Assoc Scientist R&D, RNA Assay Development Hayward, CA $125,000.00-$145,000.00 2 weeks ago Scientist I/II, Biologics Cell Line Development San Francisco Bay Area $75,000.00-$115,000.00 1 month ago San Mateo County, CA $60.00-$70.00 2 days ago Principal Clinical Research Scientist # 4365 South San Francisco, CA $100,000.00-$200,000.00 6 days ago Alameda, CA $86,700.00-$173,300.00 1 week ago Scientist — Quality Control Biologics (Clinical Analytical Operations) San Francisco Bay Area $136,340.00-$176,440.00 3 weeks ago Development Associate II to Associate Scientist AI Research, Health, Clinical Specialist Mountain View, CA $146,000.00-$214,000.00 9 hours ago Fremont, CA $15,000.00-$250,000.00 1 week ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. #J-18808-Ljbffr OneDigital NorCal HR Consulting
$195.67k - $253.22k
...confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Principal Scientist, Analytical Operations at Gilead you will act as the Quality Control (QC) Lead and will be responsible for the strategic...PrincipalContract workFor contractorsLocal areaGilead Sciences
Foster, CA1 day ago$225k - $275k
...Principal Scientist ID 2025-2214 Location US-CA-Menlo Park Practice Polymers and Chemistry Position Type Full-time Posted Salary Range USD $225,000.00 - USD $275,000.00 /Yr. About Exponent Exponent is the only...PrincipalFull timeWork at officeFlexible hoursExponent
Menlo Park, CA4 days ago$143.2k - $265.9k
The Opportunity SE7 As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research...PrincipalFull timeLocal areaRelocation package$143.29k - $266.11k
This role is a vital part of our Cell Therapy Process Development team within Pharma Technical Cell and Gene Therapy Development (PTCC), which is committed to advancing next-generation cell therapies through innovative metabolomics research and media optimization. As a...PrincipalLocal areaRelocation packageF. Hoffmann-La Roche AG
South San Francisco, CA5 days ago$124.3k - $230.9k
...Overview We are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory innovation and technical depth to join our Synthetic Molecule Analytical Chemistry (SMAC) group. The successful candidate will thrive at the bench and...PrincipalLocal areaRelocation packageF. Hoffmann-La Roche AG
South San Francisco, CA3 days ago$168.6k - $313k
...s what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics...PrincipalLocal areaRelocation packageGenentech
South San Francisco, CA1 day ago$143.2k - $265.9k
...The Position The Opportunity We are seeking a creative and highly motivated Principal Scientist, Medicinal Chemist to join our R&D team. This is a primarily lab-based, technical leadership position within the Peptide Therapeutics department. In this lab-based leadership...PrincipalLocal areaRelocation packageGenentech
South San Francisco, CA3 days ago- ...Cambridge, MA, driven by scientific rigor, translational urgency, and a patient-anchored mandate. The Institute is seeking a Principal Scientist, Cell Modeling to lead the design, generation, and characterization of the human cell systems that underpin its therapeutic...PrincipalContract work
- ...intellectual integrity, service ownership, and creative impact. Role Description: We are looking for an experienced, hands-on antibody scientist with deep expertise in antibody discovery, characterization, and antibody drug conjugate (ADC) development to join our team. In...PrincipalFull time
$124.3k - $230.9k
...with the people we love. That what makes us Genentech! Overview The Opportunity: We are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory innovation and technical depth to join our Synthetic Molecule Analytical Chemistry...PrincipalLocal areaRelocation package- ...Analytical Development (AD) and Quality Control (QC) as it advances from Phase I toward Phase II development. As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with...PrincipalFlexible hours
$307k - $427k
...guardrails protect against genuine misuse without bottlenecking legitimate scientific innovation. Partner closely with Research Scientists, Engineers, and ethics experts to embed biosecurity protocols directly into the model development lifecycle. Refine and directly...Principal$130.7k - $163.4k
Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics team dedicated to early cancer detection. As a core member of the Research and Development department, you will play a pivotal role in designing and implementing innovative computational solutions...Full timeImmediate startWorldwide$229k - $269k
...Revolution Medicines is seeking a Senior Machine Learning Scientist in Redwood City, CA to enhance drug discovery using advanced analytics and AI. The candidate will develop predictive models and work at the intersection of data science, chemistry, and biology. Key responsibilities...REVOLUTION Medicines
Redwood City, CA17 hours ago$215.3k - $344.6k
...Visa is seeking a Lead Research Scientist in Foster City, California. In this hybrid role, you will drive quantum information research to shape Visa's strategic vision. The ideal candidate requires a Ph.D., 5+ years of experience, and a proven track record in quantum computing...Visa
Foster, CA1 day ago$200k - $300k
...and exceptional customer experiences, we are on a mission to set new standards in online gaming. We are now looking for a Senior/Principal Software Engineer to join our dynamic team. This key role will help shape the architecture, design, and development of our platform...PrincipalLocal areaOverseasBellota Labs
Redwood City, CA16 hours ago$100k - $160k
...about the right treatments for the right patients, at the right time. We are seeking a highly motivated and capable Bioinformatics Scientist to join our Liquid Biopsy Science team. This role will focus directly on assay and algorithmic development, optimization, and...Full timeRemote work$180k - $200k
...A high-functioning family office in Atherton, CA is seeking an Executive Assistant to support their Principal. The ideal candidate is adaptable, with at least 5 years of experience in a similar role. Responsibilities include managing a dynamic calendar, coordinating travel...PrincipalFull timeWork at officeBespoke Private Service
Atherton, CA3 days ago- At Oracle Cloud Infrastructure (OCI), we are building the next generation of cloud services for autonomous and intelligent robotics. The OCI Robotics Cloud team is developing a secure, scalable, and cloud-native robotics platform that enables customers to seamlessly ...PrincipalFull timeFlexible hours
$155k - $180k
Description:s, control strategy/validation/PPQ‑supporting documentation, and Module 3 DP sections (IND and BLA). ~ Contribute to the establishment of DP best practices and mentoring of future DP hires as the team scales. Position Requirements & Qualifications: ...PrincipalFull timeLocal area- ...Job Description Job Description Position Summary We are seeking an innovative and highly motivated Supervising Principal Scientist with expertise in cell therapy process development and people management. This individual will interface across many parts of the organization...PrincipalFlexible hours
$229k - $269k
...patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a Senior Machine Learning Scientist to help accelerate drug discovery through advanced analytics and artificial intelligence. This role will develop predictive models...Full timeLocal areaREVOLUTION Medicines
Redwood City, CA5 days ago$155k - $180k
...therapy on-demand, more reliably, and at greater scale to more patients. About the role: Allogene Therapeutics is seeking Principal Scientist, Cell Starting Material - Process Sciences group within the Process and Product Development organization. This role will be...PrincipalFull timeLocal area$155k - $180k
...on-demand, more reliably, and at greater scale to more patients. About the role: Allogene is seeking a highly motivated Principal Scientist to lead the Pilot Plant function within Process & Product Development (PPD). This individual will serve as a technical and...PrincipalFull timeInternshipLocal area$255.8k - $402.7k
...Job Description The Clinical Director (Principal Scientist) has primary responsibility for the strategic planning and directing clinical research activities involving investigational compounds in Immunology. With a focus on late-stage development, the Clinical Director...PrincipalFull timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$185k - $250k
Senior Geologist Terra AI is building a new category at the intersection of artificial intelligence, geoscience, and critical resource development. As global demand for copper, lithium, nickel, rare earth elements, geothermal energy, and other strategic resources accelerates...Remote workterra.ai Inc.
Redwood City, CA4 days ago$85k - $100k
Senior Analytical Scientist Location: Menlo Park, CA Pay Rate: $85,000-100,000 Advance Peptide Discovery with Cutting-Edge Mass Spectrometry Staffmark is seeking an experienced Senior Analytical Scientist for a consulting opportunity supporting an innovative peptide discovery...- We’re seeking a Senior Product Marketing Manager who is passionate about understanding customer needs and pain points, influencing product strategy, and continuously improving how customers engage with our products. This role offers the opportunity to join a dynamic, high...Principal
Method Recruiting, LLC
Menlo Park, CA3 days ago - ...precision medicine, AI-based drug discovery, and translational research. Job Description The company has an opportunity for a Senior Scientist with expertise in single-cell genomics and assay development to execute the biological validation and translational application of...
$140k - $175k
...another casino app — it’s a competitive ecosystem where players learn, train, and play to win real prizes. We’re looking for a Senior / Principal Game Artist to help define the visual identity of our games and player experiences. This role is focused on creating world-class...PrincipalBellota Labs
Redwood City, CA2 days ago
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