Senior Scientist

Sansimeon is a life science tools company developing next-generation single-cell sequencing solutions that address critical barriers in clinical and translational research. Our technology enables scalable and reproducible single-cell sequencing, advancing clinical relevance and expanding applications in immunotherapy, precision medicine, AI-based drug discovery, and translational research. Job Description The company has an opportunity for a Senior Scientist with expertise in single-cell genomics and assay development to execute the biological validation and translational application of our sample preparation platform. The ideal candidate will be a strong communicator who thrives in a dynamic start-up environment, working closely with our San Carlos, CA–based team and collaborating with our Boston-based technical team. Responsibilities Execute the biological validation and translational application of Sansimeon’s sample preparation platform, including design and execution of experiments that quantify platform performance and demonstrate significance for clinical and translational single-cell sequencing workflows. Perform single-cell sequencing library preparation, sequencing runs, and quality assessment, including analysis of gene detection, UMI counts, ambient RNA contamination, and cell-type composition. Collaborate closely with cross-functional team members in engineering, bioinformatics, and operations to align assay development with overall system requirements. Prepare and maintain project documentation, including experimental plans, protocols, and technical reports, in compliance with internal quality standards. Engage with translational researchers in oncology, immunology, and cell therapy to understand unmet needs and translate those into experimental priorities and use cases. Generate data that supports business development, partnership discussions, and investor communications. Maintain biological samples (cell culture, blood/PBMCs, tissue sample acquisition) for R&D use. Qualifications PhD in genomics, molecular biology, bioengineering, immunology, or a related discipline, with hands-on single-cell sequencing experience (10X Chromium, BD Rhapsody, Parse Evercode or similar platforms). 1–2 years of postdoctoral or industry experience, ideally in a translational or clinical research setting working with primary human samples. Demonstrated ability to design, execute, and interpret rigorous experiments, with strong skills in data analysis and scientific communication. Strong capability with various molecular biology techniques (PCR, qPCR, assay design). Experience with NGS library preparation workflows, sequencing data QC metrics, and standard bioinformatics tools for single-cell analysis (Seurat, Scanpy, or equivalent). Experience with CITE-seq, cell hashing, or other multi-modal single-cell assays is a plus. Experience with mammalian cell culture techniques and sample preparation methods for single-cell sequencing. Experience in cell sorting a plus. Interest in engaging with external researchers and understanding how scientific evidence translates into product and commercial value. Self-starter who requires minimal supervision and works with a sense of urgency. Strong attention to detail, organizational skills, and technical writing ability. #J-18808-Ljbffr Sansimeon