Principal Scientist, Analytical Development - Gene Therapy
$71.25k - $187kScorpion Therapeutics
Job Responsibilities: Follow relevant business, compliance, regulatory, quality, environmental, and safety policies; make sound technical decisions and communicate them to others. Manage project deliverables across multiple projects/phases; may serve as project lead. Execute and assess analytical methods; set up, operate, and troubleshoot instruments (AUC, bioassay, ELISA, vector genome titer). Perform routine analytical and in vitro bioassays to characterize product quality, strength, and potency. Document results using good documentation practices (e.g., ELN, test data worksheets). Basic Qualifications: BS with 10+ years OR MS with 8+ years in analytical development/molecular biology/biochemistry/chemistry/biotech/chemical engineering or related field. Experience leading analytical method development, qualification, validation, transfer, and lifecycle management in regulated environments (e.g., GMP) for gene therapy/advanced modalities. Track record supporting early/late-stage development, comparability, regulatory submissions, and/or commercial readiness for viral vector/gene therapy. Preferred Qualifications / Skills: Potency and functional assay development/execution (cell-based; MOA-relevant). Hands‑on ELISA, cell‑based assays, AUC; qPCR/ddPCR, vector genome quantification, capsid/impurity analysis (highly preferred). AAV knowledge; production models (HEK293 or Bac/SF9); critical quality attributes; phase-appropriate analytical strategy; leadership in technical strategy/risk. Experience with CRO/CDMO/testing lab collaborations; data integrity/compliance; mammalian cell culture/aseptic techniques (preferred). Work Authorization: Must be authorized to work in the U.S. full‑time; no visa sponsorship. Compensation/Benefits (eligible employees): Anticipated base pay: $71,250–$187,000; possible company bonus; 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance, leave benefits, and well‑being benefits. #J-18808-Ljbffr Scorpion Therapeutics
Vacancy posted 5 days ago
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