Principal Scientist, In Vitro Pharmacology

Use Your Power for Purpose At Pfizer, our purpose is to deliver breakthroughs that change patients' lives. Your work will directly impact the development of therapies and vaccines that improve patients' lives globally. By leveraging advanced science and cutting‑edge technologies, you will play a crucial role in transforming innovative ideas into life‑changing medical solutions. Whether you are involved in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your contributions will be vital in accelerating the delivery of top‑tier medicines to patients worldwide. What You Will Achieve The key strategic focus within the Internal Medicine Research Unit (IMRU) is identifying novel therapies for the treatment of obesity and cardiovascular diseases. As a member of the In Vitro Pharmacology team, you will be playing a significant role in the early drug discovery process by developing in vitro screening assays using pharmacology expertise in GPCRs, enzymes, and other target protein classes. In addition, you will contribute to the mechanistic understanding of emerging therapeutic hits, support lead optimization efforts, and work collaboratively with project teams and across partner lines to advance programs into the clinic. Strong technical and problem‑solving skills, self‑motivation, communication skills, and the ability to both lead and thrive as part of a team are essential. In this role, you will: Develop assays for in‑vitro screening using binding, signaling and functional endpoints and support low to medium throughput screening. Validate in‑vitro cell models using immortalized, primary cells, and co‑culture systems and adapt to cell‑based screening assays at the required throughput. Independently conceptualize, design and conduct in‑vitro studies aimed at dissecting the complex molecular pharmacology of emerging therapeutic modulators targeting GPCRs, enzymes, and other protein classes within the IMRU portfolio. Apply rigorous data analytical methods to ensure robust scientific interpretation of results. Translate experimental results to advance understanding of target biology and help define how physiological endpoints are impacted by pharmacological agents. Facilitate and co‑author manuscript submissions and publication to high‑impact peer‑reviewed journals. Maintain an awareness of "cutting edge" scientific and technical developments in preclinical to clinical translation and apply these to advance portfolio programs. Ensure that all research/discovery work is conducted with highest quality and ethical guidelines and in accordance with relevant regulatory, QC, and compliance guidelines. Here Is What You Need (Minimum Requirements) BA/BS and 12 years or MS and 9 years or PhD and 4 years of relevant experience in biochemistry, cell biology and/or pharmacology. Industry and cardiometabolic experience are a plus. Experience supporting in vitro screening in a drug discovery environment involving a diverse mix of GPCR, enzyme, and other protein classes as pharmacological targets , with strong plate‑based pharmacology background . Lab automation experience is a plus. Experience with Mechanism of Action (MoA) or molecular pharmacology work, including hands‑on experience with traditional and novel screening methodologies and concepts related to GPCR and enzyme drug discovery, signaling and trafficking . Background on cell‑based assay development and extensive mammalian cell culture experience. Scientific rigor with demonstrated ability to review critically available data and think independently and creatively in formulating and testing novel scientific hypotheses. Excellent communication and interpersonal skills and ability to work independently and as part of an interdisciplinary team in a collaborative environment. Strong scientific writing skills supported by a successful record of publications in high‑impact pharmacology journals and presentations at international conferences Ability to mentor junior colleagues both technically and scientifically.

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. Ability to perform laboratory bench and tissue culture work. The annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share‑based long‑term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation support available Work Location Assignment: On Premise Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email View email address on click.appcast.io. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. #J-18808-Ljbffr Pfizer Belgium