Principal Scientist, Immunopeptidomics

Locations

Cambridge, Massachusetts, United States of America.

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Biological Research

Job Category

Scientific/Technology

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Purpose

Do you want to use your hard‑earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high‑scale proteomic analysis! Be part of a motivated team deploying innovative mass spectrometry technologies to tackle challenges in end‑to‑end drug discovery and development across a leading multiomics organization. We work shoulder‑to‑shoulder across biology, chemistry, and data science to deliver clear, reproducible proteomic readouts that move medicines forward. With your help, we will drive development of medicines for our patients!

You Will Be Responsible For

• Leading must-win immunogenicity projects across biologics, CAR‑T, and peptide therapeutics from early discovery through candidate selection.
• Owning the design, implementation, and execution of novel high throughput assays; continuously improving methods and workflows to enhance efficiency and quality.
• Translating assay results into clear, decision‑enabling interpretations for program and engineering teams. Ensuring strong data integrity, documentation, and reproducibility.
• Driving rapid innovation and providing technical leadership, while building strong multi‑functional relationships as a scientific partner.
• Developing and operationalizing population‑aware immunogenicity risk assessment strategies, ensuring consistent application across programs and integration within discovery and engineering cycles.

Education

PhD in Immunology, Biochemistry, Cellular/Molecular Biology, Bioengineering or related field is required.

Qualifications / Requirements

• PhD in Immunology, Biochemistry, Cellular/Molecular Biology, Bioengineering or a related field is required.
• 6+ years of proven biotech or pharmaceutical experience is required.
• Demonstrated expertise in immunology with hands‑on experience developing, implementing, and interpreting complex immune cell‑based assays is required.
• Strong cross‑functional communication skills with the ability to translate multi‑dimensional datasets into a decision‑relevant narrative is required.

Preferred

• Hands‑on experience with LC‑MS instrumentation in support of immunopeptidomics workflows is preferred.
• Experience developing high‑throughput assay workflows from pilot to scalable routine deployment is preferred.
• Hands‑on experience with integrated lab automation systems is preferred.
• Familiarity with therapeutic engineering concepts is desirable.
• Experience working with in silico tools and integrating computational outputs with experimental data is preferred.

Compensation

The anticipated base pay range for this position is $117,000 to $201,250.

Benefits

• Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following company‑sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long‑term disability, business accident insurance, and group legal insurance.
• Subject to the terms of their respective plans, employees are eligible to participate in the company’s consolidated retirement plan (pension) and savings plan (401(k)).
• Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
  • Vacation – 120 hours per calendar year
  • Sick time – 40 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year
  • Holiday pay, including floating holidays – 13 days per calendar year
  • Work, personal and family time – up to 40 hours per calendar year
  • Parental leave – 480 hours within one year of the birth/adoption/foster care of a child
  • Condolence leave – 30 days for an immediate family member; 5 days for an extended family member
  • Caregiver leave – 10 days
  • Volunteer leave – 4 days
  • Military spouse time‑off – 80 hours

Posting Information

This job posting is anticipated to close on 06/02/2026. The company may, however, extend this time‑period, in which case the posting will remain available on the company career site to accept additional applications.

Equal Opportunity Employer

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Accommodations

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via the company career contact page; internal employees contact AskGS to be directed to your accommodation resource.