Associate Research Scientist

Associate Research Scientist

Location: Alameda, CA Type: Contract Compensation: 40/hr Work Model: Onsite – onsite Hours: 40.0

Responsibilities

• Independently develop, optimize and execute small molecule compound profiling and HTS biochemical and biophysical assays • Consistently contribute to the design, planning, and execution of HTS campaigns and mechanism of action (MoA) studies • Independently nominate, evaluate, and implement new technologies, protocols, and workflows to support projects from hit finding, hit validation, to lead optimization stages, as well as MoA studies • Collaborate with internal teams and departments to discuss and resolve project and/or department needs • Present data and reports on project status to department head/manager and at research meetings • Communicate scientific results to manager, department, and project team partners and/or collaborators • Maintain laboratory notebooks in a complete, consistent, and concise manner in accordance with company policies • Comply with company health and safety policies and general laboratory practices • Other responsibilities, as assigned

Requirements

• Hands-on experience with biophysical and biochemical assay technologies relevant to small molecule drug discovery is required • Thorough knowledge of surface plasmon resonance (SPR) techniques for characterizing small molecule-protein complexes is highly desired • Experience with assay development for HTS applications and designing workflows is required • Significant experience developing assays in 1536- and 384-well plate formats is required • Hands-on experience with laboratory automation equipment such as liquid handlers, dispensers, and readers is a strong plus • Broad understanding of biophysical (SPR, MST, NanoDSF, BLI, thermal shift assays, etc.) and biochemical assays (HTRF, AlphaLISA, Lumit, MSD, ELISA, FP, GLO, etc.) • Ability to apply automation tools to assay development and execution • Awareness of current scientific literature and advancements in drug discovery technologies • Experience with heterobifunctional degraders or molecular glues is a plus • Education: Bachelor's degree in related discipline + 5 years of related experience; or Associate's degree + 7 years; High School Diploma/GED + 9 years • Excellent laboratory, communication, and interpersonal skills