Associate Scientist, Pharmacology

Cartography Biosciences is advancing a differentiated oncology pipeline of antibody-based therapies designed to target tumors with unprecedented precision. The company’s ATLAS and SUMMIT discovery platforms are powered by an industry-leading, fully integrated dataset spanning hundreds of thousands of cell states across healthy tissues alongside large-scale single-cell profiling of patient tumors. By combining petabyte-scale proprietary data, machine learning, and AI-driven biological insights, Cartography is identifying highly specific tumor targets and logic-gated target combinations to generate therapies engineered for maximal tumor selectivity and meaningful patient impact. The company’s lead program, CBI-1214, is a T-cell engager in development for colorectal cancer. CBI-1214 entered the clinic in early 2026 and is currently enrolling and treating patients in a phase 1 trial. Cartography Biosciences is seeking a highly motivated Associate Scientist to join our Pharmacology team and play a pivotal role in the in vitro development and characterization of novel T cell engagers across our pipeline. This lab-focused role centers on high-throughput functional screening as well as secondary characterization assays. The ideal candidate brings experience in T cell biology, in vitro assay development and MoA studies. Key Responsibilities Execute high-throughput in vitro screening assays for T cell engagers, such as in vitro cytotoxicity Perform characterization assays, including flow cytometry Maintain and expand primary cell culture (PBMCs, primary T cells) and cancer cell line culture Design, execute, and troubleshoot assays independently as well as in collaboration with others Maintain accurate, well-organized records in the electronic lab notebook (ELN) and contribute to SOP development and assay documentation Analyze, visualize, and interpret experimental data (e.g., FlowJo, GraphPad Prism, Excel) Contribute to general lab operations, including reagent preparation, equipment maintenance, and inventory management Summarize and present experimental results and progress updates at team meetings Qualifications Master's/Bachelor's degree in Biology, or a related scientific field 3+ years of relevant hands-on laboratory experience in academia or industry Proficiency in tissue culture, including both primary cell culture (e.g., PBMCs, primary T cells) and cancer cell line maintenance Experience in T cell biology and in vitro functional assays Hands-on experience with flow cytometry Strong analytical skills, with the ability to independently analyze, interpret, and troubleshoot experimental data Excellent organizational skills, attention to detail, and accurate record-keeping (ELN) Self-motivated, adaptable, and proactive in a fast-paced environment Demonstrated team player with a professional and positive attitude Strong written and oral communication skills Able to be on-site and in person 5 days a week Preferred Experience working with T cell engagers is strongly preferred Familiarity with TDCC and on-cell binding assays Experience with data analysis software such as FlowJo and GraphPad Prism Location South San Francisco, CA — on-site, 5 days a week (Pharmacology team). #J-18808-Ljbffr Cartography Biosciences