Executive Director, Clinical Program Lead

Executive Director, Clinical Program Lead (CPL)

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:

We're looking for an Executive Director, Clinical Program Lead (CPL) to help us expand what's possible for patients with serious diseases. Reporting to the Clinical Therapeutic Area Head, Respiratory, the Executive Director, CPL will provide clinical leadership for a respiratory asset across late Phase 2 and Phase 3b development. This role is a core member of the Global Project Team (GPT) and leads the Global Clinical Team, overseeing physicians and clinical scientists responsible for study design, execution, safety oversight, and supporting regulatory engagements.

What You'll Do:

In this role, you'll have the opportunity to own and maintain the global Clinical Development Plan (CDP) aligned to the Target Product Profile (TPP) and portfolio strategy. You'll also:

• Serve as clinical lead on the cross-functional GPT, accountable for all clinical strategy and deliverables.
• Provide senior medical oversight of global studies, including benefit–risk assessment, safety signal management, and clinical input to regulatory interactions (FDA, EMA, PMDA).
• Lead the design of mid-to-late-stage clinical trials ensuring compliance with ICH-GCP, ethical standards, and global regulatory requirements.
• Build, lead, and develop a high-performing global clinical team of physicians and scientists to support current and future programs.
• Establish and maintain strategic relationships with key external experts, investigators, and advisors supporting the development program.

Who You Are:

You must have an MD or MD/PhD and 10+ years of clinical development experience in biotech or pharma, with late-stage program leadership across small molecules and biologics. Additionally, you have:

• Demonstrated leadership of global Phase 2–3b programs, including clinical strategy, execution, and data interpretation.
• Strong knowledge of global regulatory pathways and interactions (FDA, EMA, PMDA).
• Proven ability to lead and influence in complex, matrixed, cross-functional organizations.
• Exceptional written and verbal communication skills with scientific, regulatory, and executive stakeholders.
• Strategic clinical judgment and scientific rigor.
• Ability to influence and act decisively within matrixed environments.
• Executive-level communication and external presence.
• Ability to navigate ambiguity and drive timely, high-quality decisions.
• Commitment to patient safety, data integrity, and ethical standards.

Nice to have (but not required):

• Board certification in Pulmonary or Allergy strongly preferred.
• Combination drug–device experience focusing on respiratory diseases strongly preferred.

Where You'll Work

This is a hybrid role based out of our Bridgewater, NJ office. You'll have the option to work remotely most of the time, with in-person collaboration when it matters most.

Travel Requirements

This role requires occasional domestic or international travel (approximately 20%).

Pay Range:

$306,000.00-417,000.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.