Principal Scientist, Target Binding

Generate Biomedicines seeks a Principal Scientist to lead target binding efforts within the Protein Analytics & Biophysics department. This role combines technical expertise in biophysical assay development, technology innovation, cross-functional program leadership, and direct management of junior scientists across multiple biotherapeutic discovery programs.

Responsibilities

• Lead target binding strategy and execution across multiple biotherapeutic programs
• Design, develop, and optimize quantitative protein-protein interaction and cell-binding assays
• Develop approaches to measure affinity, kinetics, stoichiometry, and complex binding mechanisms
• Advance the target binding platform by evaluating and implementing emerging technologies
• Establish standards for assay quality, instrumentation, data processing, and reproducibility

Requirements

• Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, or related discipline
• 8+ years of relevant industry experience in protein-protein interaction assay development
• Deep expertise with SPR, BLI, KinExA, and cell-binding measurement technologies
• Demonstrated success characterizing complex protein interactions and developing novel measurement methods
• Experience leading scientific strategy across cross-functional programs
• Proven track record managing and mentoring scientists or research associates
• Strong quantitative, statistical, and problem-solving skills