Senior Research Associate: Histology

Senior Research Associate - Permanent - San Francisco, CA Passionate about transforming tissue into breakthrough insights? Step into a role where your histology expertise drives real drug discovery impact. We are seeking a Senior Research Associate to join our client's dynamic team in CA, US. Primary Responsibilities The successful candidate will support research projects by performing histological procedures, including tissue preparation, sectioning, standard staining, immunostaining, imaging, and image quantification. Skills & Requirements MS in Biology or a similar discipline with at least 4 years of industry experience, or a BA/BS with 6 years of relevant experience demonstrating direct participation in drug discovery efforts by IHC and other tissue-based techniques ASCP certification (HT or HTL) is desirable Experience in performing, optimizing, and implementing qualitative and quantitative tissue-based methodologies, ranging from tissue handling and processing, sectioning with microtome or cryostat, and histochemical staining, is required Experience with standard and advanced microscopy and digital pathology is required Proficient at employing whole-slide automated image analysis (e.g., HALO and Definiens) and analyzing large data sets using statistical and data visualization programs (e.g., Prism, Spotfire) to quantify tissue-based efficacy markers is preferred Understanding of mouse and human comparative microscopic anatomy, characterization of transgenic animals Familiar with the analysis and interpretation of data generated from tissue-based target expression studies, with statistical approaches, and successful presentation of pathology The Senior Research Associate's responsibilities will be: Preparation of tissue, including grossing and embedding Sectioning tissue using various equipment, including cryostat, microtome, vibratome, and sliding-frozen microtome High volume automated and manual Immunostaining Experience with chromogenic and fluorescence immunodetection (single and multiplex) Experience with automatic slide stainers such as Leica Bond Rx and Biocare IntelliPATH FLX is a plus Manual and automatic cover-slipping Experience with high-throughput slide scanners such as Hamamatsu Nanozoomer and Zeiss Axioscan is a plus Capturing images with fluorescence and brightfield microscopy Carry out histological staining such as H&E, nuclear counterstaining, and other standard histological stains Design and troubleshoot experiments, analyze data, and present in meetings with guidance from senior staff Use of a microscope to examine the quality of staining, perform standard microscopic tasks, view samples, and produce high-quality images Work with CRO for the outsourcing of tissue embedding and sectioning, when necessary Compensation $120 000 - $140 000 Per Annum Contact Shannon Briggs at View email address on click.appcast.io. By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data. #J-18808-Ljbffr Proclinical Group