Senior Scientist I / II - Translational Experimental Cancer Biology (OTR)

Band Level 3 Job Description Summary Job Title: Senior Scientist I / II – Translational Experimental Cancer Biology (OTR) #LI-Onsite Location: Cambridge, USA Relocation Support: This role is based in Cambridge, USA. Novartis is unable to offer relocation support: please only apply if accessible. Drive the mechanistic understanding of how cancer therapies succeed—and fail—at the cellular level. Within Oncology Translational Research, you will interrogate therapeutic response and resistance in breast cancer using advanced molecular and cellular biology approaches, including engineered human cell line systems and functional assays. Working at the interface of discovery and early clinical development, you will generate high-resolution insights into intrinsic and acquired resistance pathways, enabling patient stratification strategies and informing the design of next-generation therapies with improved efficacy, durability, and safety. Job Description Key Responsibilities Lead mechanism-of-action studies to interrogate therapeutic response and resistance in breast cancer models Design and execute in vitro assays to uncover intrinsic and acquired resistance pathways Engineer and optimize human cell line models for functional screening and mechanistic investigations Collaborate cross-functionally across discovery, data science, and early clinical development teams Analyze, interpret, and clearly communicate experimental data to drive translational insights Document experiments rigorously and maintain high-quality scientific records and reproducibility standards Stay current with emerging scientific literature and integrate new methodologies into research strategies Essential Requirements Doctor of Philosophy in biology, cancer biology, molecular biology, or a related scientific discipline Strong expertise in cell biology and advanced molecular biology techniques Proven experience studying resistance to small molecule therapies using molecular approaches Deep understanding of hormone-driven cancer biology, including breast or prostate cancer Experience designing and executing in vitro assays to investigate cellular mechanisms Demonstrated ability to engineer and work with human cell line models Strong problem-solving skills, scientific curiosity, and ability to interpret complex biological data Proven ability to collaborate effectively within multidisciplinary scientific teams Desirable Requirements Experience with data mining and computational analysis applied to biological datasets Familiarity with single-cell sequencing or spatial transcriptomics approaches Novartis Compensation and Benefit Summary: The salary for this position is expected to range between $98,700.00 - 183,300.00 USD Annual per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to View email address on click.appcast.io call View phone number on click.appcast.io and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $98,700.00 - $183,300.00 Skills Desired Analytical Skill, Analytical Skill, Analytical Thinking, Biotechnology, Collaboration, Communication Skills, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Dna Extraction, Drug Discovery, Ethics Laboratory, HPLC (High-Performance Liquid Chromatography), Immunology, Lifesciences, Machine Learning (ML), Molecular Biology, Operational Excellence, Organization, Presentation Skills, Problem Solving Skills, Project Teams, Reports Writing, Research {+ 2 more} Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing people’s lives. 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