Scientist, Cell Therapy Process Development (In Vivo CAR-T)

Position Summary The CT‑PRE team is seeking a Scientist to help translate next‑generation cell therapies from early research into robust development platforms. The Scientist will design and execute laboratory experiments both independently and collaboratively, contributing to a highly interactive, matrixed, agile, team‑driven environment. Responsibilities Design and conduct laboratory experiments to evaluate gene delivery and cell engineering strategies for CAR‑T manufacturing feasibility. Lead workstreams and experiments focused on the optimization and implementation of scalable lentiviral vector production for in vivo CAR‑T therapy platforms. Document experimental workflows, results, and deviations in electronic laboratory notebooks to ensure reproducibility and process understanding. Perform data analysis and communicate findings clearly to enable informed decision‑making by research and development teams. Participate in cross‑functional project teams and effectively communicate CT‑PRE activities, data, and recommendations. Collaborate closely with team members to coordinate experimental execution and deliver study outcomes. Train and mentor junior team members as appropriate. Demonstrate strong scientific rigor through critical thinking, problem‑solving, troubleshooting, and attention to detail. Qualifications Bachelor’s Degree and 5+ years of academic and/or industry experience. Master’s Degree and 3+ years of academic and/or industry experience. Ph.D. or equivalent advanced degree in Life Sciences. Preferred Qualifications Experience with viral vector process development, including upstream production (e.g., suspension culture, transfection parameters, bioreactor scale‑up) and downstream purification and concentration strategies. Experience developing and optimizing bioprocesses that are intentionally designed for scalability into STR culture and manufacturability. Strong understanding of viral transduction mechanisms, tropism and integration. Proficiency with aseptic mammalian cell culture, preferably including primary T cell culture, activation and expansion. Familiarity with analytical characterization and critical quality attributes for an in vivo CAR‑T drug product (titer, purity, potency, sterility). Understanding of T‑cell biology and immunology relevant to CAR‑T – activation, transduction efficiency, phenotype and functional assays. Experience with T‑cell manufacturing workflows – apheresis material handling, activation, gene delivery, expansion, formulation. Understanding of statistical design of experiments methodology and data analysis for process optimization. Familiarity with lipid nanoparticle (LNP) or other nanoparticle‑based delivery systems for in vivo and/or ex vivo T‑cell targeting and engineering. Knowledge of, or hands‑on experience with, site‑specific gene‑editing (preferably CRISPR‑Cas, base or prime editing) technologies. Working knowledge of analyzing and interpreting data from flow‑based cellular, and PCR/sequencing based molecular assays. Awareness of incorporation of cell‑targeting ligands in vectors, for in vivo T‑cell, or organ‑selective targeting. Effective written and verbal communication skills for exchanging technical and scientific information with cross‑functional teams. A collaborative team player who can effectively multi‑task as well as excel independently in a fast‑paced, dynamic and innovative environment. Compensation Seattle – WA: $122,810 - $148,814. The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience. #J-18808-Ljbffr Bristol-Myers Squibb