Vice President, Medical Affairs Oncology

About Parabilis Medicines Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit [ or follow us on LinkedIn [ What’s the opportunity? The Vice President, Medical Affairs Oncology is a member of the Development Leadership Team reporting to the Chief Medical Officer. This senior executive leader is accountable for the end-to-end design and execution of the Medical Affairs strategy across Parabilis portfolio, including Scientific Communications, Medical Education, Evidence Generation, Key Opinion Leader (KOL) Engagement, Publication Planning, and Medical Information. This role ensures scientific excellence and cross-functional integration across all development programs and builds a scalable Medical Affairs organization capable of supporting global, multi-indication growth. Key Responsibilities: Strategic Leadership * Define and execute the Medical Affairs Oncology strategy aligned with the clinical development roadmap and portfolio priorities * Serve as a core member of the Development Leadership Team and contribute to broader development governance and portfolio decision-making * Support portfolio-level medical prioritization, lifecycle planning, and cross-indication strategy KOL Engagement & Medical Education * Build and sustain relationships with leading KOLs, academic medical centers, and cooperative groups relevant to Parabilis’ pipeline * Design and oversee Medical Education programs that advance understanding of Parabilis’ science, novel mechanisms, and unmet need across tumor types Evidence Generation & Publication Strategy * Lead the development and execution of a robust evidence generation strategy, including investigator-initiated studies, real-world evidence, and health outcomes research * Oversee development and execution of a comprehensive publication plan aligned with clinical milestones and regulatory timelines * Build global medical affairs infrastructure to support multi-program, multi-regional growth * Drive medical affairs KPIs and impact metrics in support of portfolio strategy and commercial readiness Scientific Communications & Medical Information * Lead scientific communications strategy to accurately and compellingly convey the differentiated profile of Parabilis’ Helicon™ platform and pipeline assets * Oversee Medical Information function, ensuring timely, accurate, and compliant responses to healthcare professional inquiries * Oversee the creation of high-quality medical education materials, slide decks, and scientific exchange resources * Establish scalable medical affairs infrastructure to support launch readiness across tumor types and geographies Patient Advocacy and Patient Support * Building trusted partnerships with advocacy organizations across Parabilis' specific tumor types * Integrating the patient voice into MA strategy, trial design, and evidence generation

• Collaborating with patient communities on disease awareness and education
• Developing patient support programs to improve access, adherence, and trial

participation ensuring all patients’ engagement is conducted with ethical rigor and full compliance Cross-functional Partnership & Commercial Readiness * Partner closely with Clinical Development, Regulatory Affairs, and New Product Planning to ensure scientific and medical alignment across the development and pre-commercialization continuum * Support payer strategies by contributing to value dossiers, HEOR data packages Compliance & Medical Governance * Lead development and continuous improvement of Medical Affairs SOPs, governance frameworks, and compliance systems * Ensure all Medical Affairs activities are executed in accordance with applicable regulations, industry codes, and Parabilis’ internal policies Organizational Leadership * Build and mentor a high-performing Medical Affairs Oncology team with deep scientific expertise and strong cross-functional collaboration skills * Establish clear accountability, performance metrics, and a culture of scientific rigor and integrity * Foster a culture of collaboration, scientific curiosity, and patient-centricity across the Medical Affairs team What you’ll need to be successful: * MD required; PharmD or PhD in a relevant biomedical discipline may be considered with commensurate experience * 15+ years of progressive biopharmaceutical industry experience, with a minimum of 8 years in Medical Affairs with deep scientific expertise in oncology * Demonstrated success building and leading Medical Affairs organizations, including KOL engagement, evidence generation, and scientific communications * Experience standing up Medical Affairs capabilities in high-growth, clinical-stage biotech or pharmaceutical environments * Strong scientific credibility, executive leadership presence, and ability to engage effectively with both internal and external stakeholders * High emotional intelligence and track record of cross-functional influence across Development, Commercial, and Regulatory functions Core Values Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit. * Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable. * In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options. * Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact. * All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history. The base salary range for this position is $360,000-$410,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being. As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law. 30 Acorn Park Drive | Cambridge, MA 02140 |