Single-Cell / Spatial Profiling Specialist

Job Description:
• The GRC is a single organization that supports and drives genomics and genetics research across R&D.
• The GRC has core capabilities and research efforts in Genomic Technologies, Functional Genomics, Computational Genomics, Human Disease Genetics, Pharmacogenetics, and has dedicated support for IT infrastructure.
• The core mission of the group is to apply genomics and genetics research to target discovery, target validation, translational research, and design and analysis of clinical trials.
• The GRC Genomic Technologies Group (GTECH) supports preclinical and clinical research teams by applying genomic profiling technologies with the goal of improving the success rates for drug discovery and development.
• The GRC is seeking to hire a scientist proficient in Next-Generation-Sequencing (NGS) to support single cell and Visium spatial transcriptomic profiling capabilities.

Skills:
• Hands-on single cell sequencing experience
• Hands-on spatial transcriptomics experience
• NGS data QC experience
• Hands-on NGS experience

Experience:
• Typically, 7 years of experience, master's degree, or equivalent education and typically 5 years of experience in molecular biology, genetics, genomics or a related field.
• Demonstrated record of high-proficiency, hands-on molecular biology experience with PCR-based assays and technical knowledge of high-throughput genomic profiling technologies with emphasis on Illumina sequencing platforms and complex library preparation workflows for bulkRNA-seq, 10X Genomics scRNA-seq, and 10X Genomics Visium spatial transcriptomics.
• Knowledge of QC metrics, interpretation , and demonstrated use of approaches for assessing the quality of samples and libraries for bulkRNA, scRNA, and spatial profiling, such as capillary electrophoresis, qPCR, fluorometry, spectrophotometry, cell counting and viability.
• Proficiency with basic bioinformatics tools and sequencing data analysis concepts, such as Illumina SAV, bcl2fastq/BCLConvert, fastQC, and working in a UNIX HPC environment .
• Experience with 10X Genomics Cellranger and/or Spaceranger software is highly preferred.
• Experience being part of a centralized high-throughput genomic lab is highly desirable.
• Proven direct end-to-end hands-on experience with 10X Genomics technologies such as single-cell RNAseq or Visium is highly preferred.
• The successful candidate will work closely with NGS technical leads and be responsible for carrying out end-to-end NGS experiments and communicating results to stakeholders and collaborators.

Key Responsibilities:
• Reporting to the Single Cell Lead, work closely with other NGS Technical Leads and staff to fulfill single cell/spatial transcriptomic profiling needs for active studies from client Genomic Research Centre (GRC) stakeholders and client therapeutic area (TA) scientists.
• Support single cell and spatial transcriptomic workflows.
• Perform sample and library prep, and sequencing, initial data QC and first pass analysis of results.
• Closely work with NGS technical leads and partner with bioinformatics specialists and disease area scientists to interpret results and troubleshooting.
• Operate and maintain NGS and its supportive platforms within centralized technology group.
• Prepare written summaries of experimental results and verbally present at team meetings.
• Maintain accurate documentation of experiments, protocols, and results. Support inventory and maintenance .
• Effectively communicate with stakeholders, especially around experimental design, troubleshooting, and responding to changes in priorities and adjusting timelines.

Qualifications:
• Bachelor's Degree or equivalent education

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