Senior Scientist, Translational Computational Biology

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. When you join BMS, you are joining a high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company. We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers. Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma. Position Summary The Oncology Translational IPS team is seeking a Senior Scientist, Translational Computational Biology, to serve as the computational partner to our oncology drug development programs across discovery, translational research, and early clinical development. You will translate patient-derived molecular, spatial, clinical, and real-world data into biomarker hypotheses, patient stratification strategies, indication prioritization, pharmacodynamic readouts, and decision‑grade recommendations. The majority of the role is embedded with oncology drug development programs and clinical development teams. The remainder builds computational capability for the broader portfolio: AI‑enabled translational science, spatial biology, and reusable analytical methods. The exact emphasis of that capability work will evolve with portfolio priorities and emerging technologies. This role is for someone who understands drug development, not only data analysis. We are looking for a scientist with a working understanding of the path from target validation and candidate selection through IND‑enabling work and early clinical studies (including dose escalation and expansion), and of the strategic role biomarkers play at each stage, who can carry an interpretation into the forum where the decision is actually made. What You Will Have To Work With Clinical and multi‑modal patient‑derived datasets from BMS's industry‑leading early‑stage clinical studies in oncology: the molecular and clinical biomarker data generated by our own early‑phase trials, spanning RNA‑seq, WES, TCR‑seq, ctDNA and CTC, together with flow cytometry, cytokine profiling, IHC, and proteomics. Layered on top of that: spatial transcriptomics and multiplex immunofluorescence across multiple concurrent oncology programs, backed by a pan‑cancer spatial atlas license and an H&E‑to‑mIF platform partnership; linked genomic‑clinical real‑world data at scale; and cloud compute alongside a translational informatics team that builds its own methods. These platforms are already funded; this role exists to realize their scientific value. Your contributions will influence development strategies and play a vital role in propelling the BMS early‑stage oncology pipeline forward, directly impacting the treatment of cancer patients. You Will Apply These Data Across Two Areas Oncology drug development program, translational, and early clinical development support. The majority of the role. Biomarker strategy; patient selection and stratification; indication prioritization; target validation; IND‑enabling and early clinical trial interpretation; data‑driven recommendations for program decisions. Computational innovation and portfolio capability. The remainder. AI‑enabled translational science; spatial biology; multimodal integration; reusable workflows, automation, and scalable analytical methods that serve the portfolio rather than a single program. Key Responsibilities Oncology drug development program, translational, and early clinical development support Oncology program partnership. Serve as the translational computational scientist for assigned oncology drug development programs across the discovery‑to‑early‑clinical continuum, from target validation through early clinical studies. Biomarker and patient strategy. Shape biomarker strategy, patient selection and stratification hypotheses, pharmacodynamic marker plans, indication prioritization, and enrichment approaches. Patient‑derived data analysis. Analyze and integrate multimodal molecular, clinical, and translational datasets from oncology studies, including bulk and single‑cell RNA‑seq, WES, ctDNA and liquid biopsy, TCR‑seq, flow cytometry, cytokine profiling, IHC, proteomics, and spatial readouts. Discovery‑to‑translational support. Use patient molecular data, causal and driver inference, regulatory network analysis, perturbation readouts, and orthogonal evidence to support target nomination, validation, candidate selection, and IND‑enabling decisions. Decision‑grade communication. Translate complex multimodal analyses into clear, decision‑grade biological narratives. Every result ships with an interpretation, its limitations, and a recommendation, and you carry that recommendation to the program team, translational review, or governance forum where the decision is made. Computational innovation and portfolio capability AI‑enabled translational science. This is an explicit mandate of the role, not a side project. Design and deploy AI approaches for evidence integration and hypothesis generation across patient omics, genetic evidence, perturbation data, and the literature, including LLM‑based extraction, agentic and multi‑step workflows, and emerging biological foundation models. Given strategic direction, you will have the autonomy to scope, build, and deploy the methods that become the team's translational decision infrastructure. You should not just run existing tools; we want someone who sees what is missing from current approaches and builds it. Spatial biology. Take dedicated analytical ownership of spatial data across the portfolio (spatial transcriptomics and spatial proteomics / multiplex immunofluorescence), and realize the scientific value of the atlas, platform, and vendor investments already committed. You will partner with digital pathology and image‑analysis colleagues on H&E whole‑slide analysis; deep prior digital pathology experience is welcome but not required. Real‑world patient data. Apply statistical inference and machine learning to linked genomic‑clinical real‑world data to support cohort definition and patient stratification, extending the team's existing real‑world capability in partnership with our real‑world data and epidemiology colleagues. Reusable methods and automation. Build reproducible workflows and cloud‑ready pipelines for multimodal data (single‑cell, CRISPR and Perturb‑seq screens, spatial), so capability persists as a team asset rather than as one‑off analyses. Scientific influence. Mentor junior scientists and interns, document methods to publication‑quality standards, and help raise the computational maturity of the broader translational organization. Basic Qualifications Bachelor's Degree 7+ years of academic / industry experience Or Master's Degree 5+ years of academic / industry experience Or PhD 2+ years of academic / industry experience Preferred Qualifications We do not expect any one candidate to bring all of the following. Depth in several of these areas, combined with the judgment to know which question a program is actually asking, matters more than breadth across all of them. Ph.D. in computational biology, bioinformatics, biostatistics, statistics, human genetics, computer science, or a related quantitative field, with 2+ years of relevant academic and/or industry experience. Demonstrated experience analyzing, integrating, and interpreting high‑dimensional patient‑derived molecular data in oncology or another translational disease area. Strong programming skills in R and/or Python, with practical experience in reproducible analysis and data visualization. Working knowledge of the oncology drug development process, sufficient to anticipate what a program needs at target validation, candidate selection, IND‑enabling work, and early clinical development. Clear scientific communication and the ability to collaborate effectively with biology, translational medicine, clinical development, statistics, and quantitative science partners. Prior experience in oncology drug development at a biopharmaceutical company, in translational sciences, discovery, or early clinical development. AI and machine learning applied to translational problems: LLM‑based evidence and literature extraction, agentic or multi‑step analytical workflows, biological foundation models, or multimodal representation learning. Experience with biomarker strategy, patient selection, pharmacodynamic readouts, companion diagnostic (CDx) development, or clinical translational data interpretation. Spatial biology: hands‑on experience with spatial transcriptomics (e.g., Visium, Xenium, CosMx, GeoMx, MERFISH) and/or spatial proteomics and multiplex immunofluorescence (e.g., Lunaphore COMET, RareCyte Orion, Akoya), including cell segmentation, phenotyping, and neighborhood or spatial statistics; familiarity with the analysis stack (Squidpy, SpatialData, scverse) and with digital pathology tooling (HALO, QuPath). Causal and driver inference, regulatory network analysis, or other approaches that nominate and prioritize targets from patient molecular data. Perturbation biology and functional genomics: CRISPR screens, Perturb‑seq, and genetic validation in patient‑derived model systems, including integrating perturbation readouts against patient data. Cell‑type inference and gene‑expression deconvolution from bulk, single‑cell, and spatial data. Large‑scale real‑world oncology data linking genomic, clinical, and EHR‑derived information, and familiarity with the statistical issues these data carry (confounding, missingness, cohort selection, longitudinal follow‑up). Reproducible engineering practice: workflow managers (e.g., Nextflow, Snakemake), version control (Git), high‑performance computing, and cloud platforms. A record of methods development evidenced by peer‑reviewed publications and, ideally, released open‑source tools or packages. A collaborative problem‑solver who can operate in ambiguous program settings and translate complex computational output into practical recommendations. Compensation Overview Cambridge Crossing: $148,210 - $179,601. The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job‑related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit Benefits Health Coverage: Medical, pharmacy, dental and vision care. Wellbeing Support: Programs such as BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well‑being and Protection: 401(k) plan, short‑and‑long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work‑life Benefits Include Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non‑Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part‑time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. Eligibility Disclosure: The summer hours program is for United States (U.S.) office‑based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote‑by‑design or lab‑based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life‑changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On‑site Protocol Responsibilities BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site‑essential, site‑by‑design, field‑based and remote‑by‑design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site‑essential roles require 100% of shifts onsite at your assigned facility. Site‑by‑design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field‑based and remote‑by‑design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People With Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to View email address on click.appcast.io. Visit careers.bms.com/eeo‑accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at View email address on click.appcast.io. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley. Job Requisition R1605028 : Senior Scientist, Translational Computational Biology #J-18808-Ljbffr Bristol Myers Squibb