Principal Scientist, Protein Design & In Vitro Selection
Moderna
A prominent biopharmaceutical firm in Cambridge is looking for a scientific leader to provide technical oversight in in vitro selection and cell-surface screening for viral and bacterial antigens. Candidates should have a PhD and at least 5 years of relevant industry experience, particularly in high-throughput screening and mammalian display systems. This role offers a unique opportunity to shape discovery capabilities and drive innovation within a dynamic team focused on advancing cutting-edge therapeutics. #J-18808-Ljbffr Moderna
$142.5k - $256.5k
...seeking a candidate to support protein design for vaccines and biologics... ...that are validated in vitro and in vivo. The candidate... ...partnership with in vitro selection and screening teams. You will... ...in vivo mRNA delivery. As a Principal Scientist, you will also help shape design...Principal$142.5k - $256.5k
...technical leadership for in vitro selection and cell-surface... ...role will lead the design, execution, and continuous... ...with computational protein design teams to... ...role is intended for a scientist ready to own and evolve... ...consistent with a Principal Scientist role.**Here...PrincipalWork at officeWork from home$142.5k - $256.5k
The Role Moderna is seeking a Principal Scientist to support the AI‑enabled design of de novo antibodies and binder modalities... ...role for an experienced protein designer who can build and... ...Director, Computational Design and In Vitro Selection, and will also work closely with...PrincipalPermanent employment$181.01k - $200.07k
...delivering on the promise of targeted protein degradation science to create... ...® platform to efficiently design and optimize small-molecule... ...Hit ID through candidate selection, including optimizing degraders... ...(DMPK) colleagues on the in vitro and in vivo optimization of...PrincipalContract work$166.77k - $202.09k
...an experienced, creative, and highly collaborative scientist to join our Biotherapeutics Computational Design team. In this role, you will build and deploy... ...models for biologics design: develop methods for protein structure modeling, binder design, affinity/specificity...PrincipalFull timeTemporary work- ...Inc. in Cambridge, Massachusetts, is looking for a Principal or Senior Principal Scientist to lead protein drug discovery for next-generation biologics. This... ...driving programs from idea through lead‑candidate selection. The ideal candidate should possess a PhD in a relevant...Principal
$220k - $270k
Principal or Senior Principal Scientist - Protein Drug Discovery Lead protein drug discovery for next‑generation biologics... ...discovery through lead‑candidate selection. The role is part of the new... ...and structure‑informed design across multiple formats (mAbs, bispecifics...Principal- ...engineering cells inside the body using AI-designed, selective mRNA and targeted LNP technology. By... ...Kernal seeks a highly motivated principal scientist for antibody development and... ...development and/or production of recombinant proteins, monoclonal antibodies, and/or...PrincipalFlexible hours
$106k - $176.6k
...cardiovascular diseases. As a member of the In Vitro Pharmacology team, you will be playing a... ...in GPCRs, enzymes, and other target protein classes. In addition, you will contribute... ...throughput. Independently conceptualize, design and conduct in‑vitro studies aimed at...PrincipalPermanent employmentH1bLocal areaWorldwideVisa sponsorshipWork visaRelocation package- ...machine, and nature’s intelligence -- which we call Polyintelligence. Pioneering Intelligence is seeking a Principal Scientist – Computational Protein Design to serve as the technical lead on computational antibody design efforts pushing the forefront of AI-based antibody...Principal
$165k - $200k
...modulating intracellular proteins that have... ...? We are seeking a Principal Scientist with deep expertise in... ...depot formulations) Design and optimize dosage forms... ...interpret biorelevant in vitro and in vivo studies... ...PK/PD and candidate selection Contribute to CMC...PrincipalShift work$74k - $118.4k
Moderna is seeking a Senior Research Associate to join its Protein Design team in Cambridge, MA. This role involves supporting protein expression screening and characterization crucial for vaccine development. Responsibilities include using mammalian cell culture techniques...$146k - $209k
A biotechnology company in Boston is seeking a Senior Scientist in Computational Protein Design to drive innovative computational design and optimization of synthetic proteins. The ideal candidate should possess a PhD and deep experience in de novo protein design and binding...$126k - $181.5k
Flagship Pioneering is seeking a Senior Scientist in Molecular Biology to design next-generation DNA constructs. The role involves developing proteins, designing complex DNA libraries, and managing workflows for high-throughput screening. Ideal candidates will have a PhD...- ...ROLE We’re looking to hire a Principal Scientist in Bioengineering or Biology... ..., including peptides and proteins, for topical and non‑topical... ...nomination, validation and selection for anti‑aging or other skin... ...experience: Pre‑clinical in‑vitro testing within dermatology and...PrincipalWork at officeShift work
- Position Overview The Principal Machine Learning Scientist II will advance deep learning methods for biologics discovery at AbbVie. This individual... ...- and structure-based deep learning models for protein and antibody design with emphasis on adapting them to the constraints...PrincipalWork at officeLocal areaRelocation3 days per week
$115.5k - $192.5k
...Find out more: Our approach to R&D The Protein Biochemistry team at the GSK Vaccines R... ...disease‑related initiatives. As a Principal Scientist, you will provide deep subject‑matter expertise... ...solutions, contribute to workflow design and method development, and ensure experimental...PrincipalLocal area$146k - $209k
Senior Scientist, Computational Protein Design Boston, MA USA About Abiologics Abiologics is a Flagship Pioneering company developing Synteins™ — a transformative class of fully synthetic proteins composed entirely of artificial building blocks such as D-amino acids and...$145.5k - $218.3k
Manufacturing Science and Technology Principal Scientist page is loaded## Manufacturing Science and... ..., Quality and R&D of Vertex on the design of processes and technologies required... ...remotely up to two days per week; **or select** 2. **On-Site**: work five days per week...PrincipalContract workSummer workRemote workFlexible hours2 days per week- ...AbbVie is seeking a Senior Scientist I with deep, hands-on... ...role will involve designing and executing innovative... ...Independently lead in vitro siRNA discovery... ...orthogonal readouts (protein, functional, and transcriptomic... ...go/no-go, lead selection, or optimization decisions...Temporary workLocal area
$148.21k - $179.6k
Senior Scientist, Computational Sciences - Computational Antibody Discovery and Design Location: Cambridge Crossing - MA #LI-Hybrid... ...sequencing and selection NGS data (such as in vitro display or in vivo immunization... ...sequence data such as protein language models, structure...Hourly payFull timeTemporary workPart timeSummer workRemote workFlexible hoursShift work- Scientist - Protein Expression (Full-Time) Location: Cambridge, MA (On-site) Company: Anthology Bio Company summary Anthology is Boston-based genome design company. We engineer fungi through advanced genetics, microfluidics, and AI to biomanufacture functional proteins...Full timeImmediate start
- Scientist, Protein Production and Screening Join to apply for the Scientist, Protein Production and Screening role at GSK Scientist, Protein... ...structural biology, protein biochemistry, and computational tools to design vaccine antigens, RNAs, delivery systems, and formulations...Full timeLocal area
- Allergan is seeking a Principal Machine Learning Scientist II based in Cambridge, MA to advance deep learning methods for biologics discovery and therapeutic antibody design. This role involves collaborating with antibody engineers and computational biologists, focusing...Principal
- Lancesoft is seeking a Principal Scientist in Cambridge, MA to lead the development of scalable, cell-based assay platforms for mRNA vaccine constructs. The role requires a PhD in a relevant field along with substantial experience in flow cytometry and microscopy-based...PrincipalContract work
- A biotechnology firm is seeking an AI/ML Scientist to enhance their models for protein therapeutic design in San Francisco or Boston. The role involves advancing model training with proprietary experimental data and requires experience in deep learning frameworks like...
$220k - $270k
Principal or Senior Principal Scientist - Peptide & Bioconjugate Drug Discovery Does it excite... ...through lead‑candidate selection, partnering closely with... ...computational chemistry, protein engineering, biology,... ...Deep expertise in peptide design, solid‑phase peptide synthesis...Principal$170k - $190k
...Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit... ...manufacture of next-generation therapeutics. We are seeking a Principal Scientist to join our Biologics Cell Line Development team in Boston,...Principal$122.25k - $176.58k
Job Title and Location Principal Scientist, Neurology Research - Cambridge, MA About the... ...single‑cell, spatial omics (RNA, protein, lipids), fluid proteogenomics (... ...progression; refine patient selection criteria for future trial designs. Champion the "Everyday AI" initiative...PrincipalShift work- Bristol Myers Squibb is looking for an experienced scientist to join their Biotherapeutics Computational Design team in Cambridge. The role focuses on utilizing machine learning and structure-based methods to enhance biologics discovery and supports the development of...
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