Senior Scientist II, DMPK

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The DMPK Scientist will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department. Responsibilities: Serve as the DMPK representative on multidisciplinary drug discovery and development teams, driving lead identification through data‑driven decision‑making and cross‑functional collaboration. Design and execute in vitro and in vivo metabolite identification studies using liver microsomes, hepatocytes, recombinant enzymes, and biological samples (blood, plasma, tissue, urine, bile, etc.), and perform metabolite profiling and structural elucidation. Characterize major, unique, or disproportionate metabolites to support candidate selection, MIST (Metabolites in Safety Testing) analysis, and metabolite regulatory strategy. Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities. Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies. Build and maintain strong collaborative partnerships across functional areas, e.g., Discovery research, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research. Required Experience, Skills, and Education: A highly motivated individual with a PhD in Pharmaceutical Sciences, Organic Chemistry, or related field, with 8+ years of experience after graduation. Demonstrated expertise in metabolite identification, structural elucidation, and profiling using state-of-the-art high-resolution mass spectrometry (HRMS). Demonstrated experience as DMPK project representative. Small molecule projects are preferred. Thorough understanding of drug metabolism, pharmacokinetics, ADME principles, and regulatory guidance related to metabolite assessment in nonclinical and clinical safety studies. Demonstrated expertise in pharmacokinetic data analysis, modeling, and interpretation using PK software such as WinNonlin. Excellent verbal and written communication, problem‑solving and critical thinking skills. Ability to independently design experiments, analyze data, and communicate results. Preferred Skills: Prior experience with oncology drug discovery. Experience with PBPK modeling, DDI risk assessment, human PK and dose projection. Salary Range: Base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is $170,000 — $212,000 USD. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io. We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness. #J-18808-Ljbffr Revolution Medicines