Lead Data Manager

$144k - $176k

Madrigalpharma

Conshohocken, PA

# Lead Data ManagerApplylocations: PA - Conshohocken - Officetime type: Full timeposted on: Posted 3 Days Agojob requisition id: JR\_000772Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.The Lead Data Manager is responsible for the independent oversight and delivery of all data management activities for assigned clinical studies, ensuring high-quality, reliable clinical trial data in accordance with regulatory standards and Madrigal Pharmaceuticals’ operational excellence principles. This position serves as the primary point of contact for Data Management on assigned trials, collaborating with cross-functional teams including Clinical Operations, Biostatistics, Programming, and external vendors. The Lead Data Manager ensures timely and accurate database delivery and plays an active role in continuous improvement of data management processes and standards across the R&D organization. Key Responsibilities • Serve as the Data Management lead for one or more clinical studies, accountable for end-to-end data management activities from study start-up through database lock. • Develop and maintain study-level Data Management Plans (DMPs), CRF completion guidelines, edit check specifications, and other data management documentation. • Lead EDC system setup, user acceptance testing (UAT), and database change control in collaboration with vendors and internal teams. • Coordinate and perform ongoing data review, query management, and data cleaning activities to ensure data integrity and completeness. • Oversee external data handling, including laboratory, ECG, imaging, PK/PD, and ePRO integrations, ensuring timely reconciliation and issue resolution. • Monitor study progress, track data metrics, and proactively identify and address data-related risks and delays. • Lead database lock planning and execution, including review of data listings and coordination of cross-functional deliverables. • Serve as the primary point of contact for CROs, EDC vendors, and functional partners for assigned studies. • Ensure compliance with Madrigal SOPs, GCP, ICH, and regulatory requirements in all data management activities. • Contribute to process improvement initiatives and provide input on departmental tools, templates, and standards. • May provide training, mentoring, and oversight to junior data management staff. Qualifications and Experience • Bachelor’s degree in Life Sciences, Computer Science, or related field. • Minimum of 5–7 years of experience in clinical data management within the pharmaceutical or biotechnology industry, including study-level lead experience. • Demonstrated proficiency with EDC systems such as Medidata Rave, Oracle InForm, or Veeva CDMS. • Strong understanding of clinical data standards (CDASH, SDTM) and data integration practices. • Working knowledge of ICH GCP, FDA, and other regulatory guidelines relevant to clinical research. • Proven ability to manage vendor deliverables, timelines, and budgets. • Excellent organizational, analytical, and problem-solving skills. • Strong written and verbal communication skills with experience presenting data management deliverables cross-functionally. • Proficiency in Microsoft Office Suite (Excel, Word, PowerPoint, Outlook). Preferred Experience • Experience leading data management for Phase II or III global studies. • Familiarity with adaptive trial designs and complex data models. • Experience managing data from multiple external vendors (e.g., imaging, central labs, ECG, ePRO, PK/PD). • Exposure to therapeutic areas such as oncology, metabolic, or cardiovascular disease. • Experience participating in regulatory inspections or sponsor audits. • Familiarity with data review and visualization tools (e.g., JReview, Spotfire, SAS listings). Core Competencies • Leadership: Provides direction and coordination to study teams and external partners. • Accountability: Drives data management deliverables to completion with minimal supervision. • Quality Focus: Maintains meticulous attention to data accuracy, completeness, and documentation integrity. • Collaboration: Works effectively with cross-functional teams to achieve clinical program milestones. • Continuous Improvement: Identifies and implements process enhancements that optimize data flow and efficiency.Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $144,000 - $176,000 per year. We comply with all applicable minimum wage laws.All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact View email address on click.appcast.io. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. *Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.* *Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to* *View email address on click.appcast.io**.*
J-18808-Ljbffr Madrigalpharma

Apply

Vacancy posted 11 hours ago

Similar jobs that could be interesting for youBased on the Lead Data Manager in Conshohocken, PA vacancy

Lead Data Manager
$144k - $176k
...member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (... ...rigor, and collaboration. Key Responsibilities Serve as the Data Management lead for one or more clinical studies, accountable for end‑to...
Suggested
Minimum wage
Full time
Work at office
Local area
Flexible hours
Madrigal
Conshohocken, PA
2 days ago
Data Domain Lead
...Lead Data Domain Steward Location: Hybrid 3 days onsite Type: Full-Time Overview We are seeking a Data Domain Lead to build and scale... ...evolving regulatory requirements Qualifications Experience in data management, governance, or stewardship, ideally within regulated...
Suggested
Full time
Liberty Personnel Services, Inc.
Conshohocken, PA
3 days ago
SR. CLINICAL DATA MANAGER
...DUTIES: • Serve as the DM study lead and the primary point of contact for clinical... ...teams and external partners, (e.g., external data vendors and CROs) for multiple trials... ...within the program • Collaborate with data management peers and other cross functional...
Suggested
Local area
ACL Digital
King of Prussia, PA
2 days ago
Lead Supervisor I
$17 - $27.75 per hour
...Coach values and increasing brand awareness. Leads implementation of company initiatives and... ...the team. Monitors and analyzes sales data, identifies trends, and makes... ...Requirements 1+ years of equivalent experience in managing competitive retail space at the Lead Supervisor...
Suggested
Shift work
Coach
King of Prussia, PA
2 days ago
Manager of Data Governance
...Job Description Job Description Manager of Data Governance A highly respected, rapidly growing organization is seeking a strategic... ...groups, to drive alignment, ownership, and issue resolution Lead governance forums and cross-functional initiatives, ensuring transparency...
Suggested
Temporary work
Liberty Personnel Services, Inc
Plymouth Meeting, PA
3 days ago
Clinical Data Manager
...Clinical Data Manager Integrated Resources, Inc., is led by a seasoned team with combined decades in the industry. We deliver strategic workforce solutions that help you manage your talent and business more efficiently and effectively. Since launching in 1996, IRI...
Flexible hours
Careers Integrated Resources Inc
Spring House, PA
2 days ago
FOH Lead
...Overview The FOH Lead is the store manager’s right hand and plays a key role in setting the tone for hospitality and daily operations. This role combines hands‑on service with leadership responsibilities, supporting opening/closing procedures, assisting with training,...
Shift work
The Buttery
Bryn Mawr, PA
5 days ago
Sr. Clinical Data Manager
...Responsibilities: The Senior Clinical Data Manager provides oversight and accountability and/or executes data management activities... ...Regulatory Agency and Pharmaceutical internal audits as necessary Lead the planning and tracking of content, format, quality, and...
Immediate start
Katalyst Healthcares and Life Sciences
Philadelphia, PA
4 days ago
Clinical Data Manager
...Tech Project Delivery Manager ZS is a place where passion changes lives. As a management... ...transform ideas into impact by bringing together data, science, technology and human ingenuity... ...a Tech Project Delivery Manager to lead a high-velocity team focused on the future...
Work at office
Local area
Work from home
Worldwide
Flexible hours
ZS Associates
Philadelphia, PA
3 days ago
Clinical Data Manager II
...Clinical Data Manager II This is a professional individual contributor role that provides oversight and accountability for more than one low to moderate complexity trial or one high complexity trial. May be a member of more than one project of low to moderate complexity...
Contract work
Immediate start
Careers Integrated Resources Inc
Spring House, PA
2 days ago
Receiving Team Lead
...Receiving Team Lead We are hiring a Receiving Team Lead at our Norristown, PA warehouse.... ...position will also take an active role in the management of inventory monitoring. Essential Job Functions: Key receiving data into the computer from purchase orders, stock...
Full time
Contract work
Temporary work
Casual work
Work at office
Local area
Monday to Friday
Midwest Veterinary Supply
Norristown, PA
2 days ago
Meat Lead Full Time
$22 per hour
## Meat Lead Full TimeApplylocations: Plymouth Meeting, PA #0092time type: Full timeposted... ...:** Get paid every week so that you can manage your money on your terms.* **Free BJ’s Memberships... ...and analyze sales, waste, and shrink data to identify opportunities for process...
Weekly pay
Full time
Seasonal work
Flexible hours
BJ's Wholesale Club
Plymouth Meeting, PA
2 days ago
Data Lead
...Data Migration Lead We are seeking a highly skilled Data Migration Lead to oversee and manage the planning, execution, and delivery of data migration projects. The ideal candidate will have deep expertise in SAP environments, hands-on experience with enterprise data...
Natuvion GmbH
Malvern, PA
4 days ago
Demand Generation Lead
...solutions, we’re seeking a Demand Generation Lead in Coopersburg, PA to scale our... ...strong marketing automation expertise , and a data‑driven, hands‑on approach to driving results... ...events, and nurture initiatives Own lead management, including lifecycle stages, scoring,...
Lutron
Conshohocken, PA
3 days ago
Sustainability Lead (Data Centers)
$91.4k
...Data Center Sustainability Lead At Jacobs, we're challenging today to reinvent tomorrow by solving the world's most critical problems for thriving... ...goals. You'll collaborate closely with project management, design teams, construction leadership, subcontractors,...
Full time
For subcontractor
Jacobs Solutions
Conshohocken, PA
4 days ago
Data Scientist Manager
...Philadelphia right now. About the Role: Our data team is organized across three groups:... ...half individual contribution and half management. You should expect to be writing code,... ...report directly to the Head of Data and lead a Data Science team that spans early-...
Odd job
Full time
Work at office
Local area
Relocation package
Weekend work
Perpay - Career's Page
Philadelphia, PA
5 days ago
Floor Lead (Retail) (Part-time)
...Floor Lead (Retail) (Part-time) Since 2015, Mejuri has reimagined what fine jewelry can be in a modern world—shifting it from a... ...supplies. Proficient in using point-of-sale systems, inventory management software, and other retail technology. Support in mitigating...
Part time
Worldwide
Shift work
Weekend work
Afternoon shift
mejuri
King of Prussia, PA
2 days ago
Team Lead
...culture built on five core values: Generosity First, Always: We lead with kindness. Our best work happens when we act in service of... ...performance success in partnership with our Assistant General Managers and General Managers by leading the team daily, promoting a...
Local area
Shift work
CAVA
King of Prussia, PA
2 days ago
Strategic Growth & Partnerships Lead
...Archwell is looking for a Strategy Manager to lead the company's strategic planning initiatives across all sectors. This role involves collaborating with various leaders to develop strategies aimed at driving corporate growth and operational efficiency. The ideal candidate...
Archwell
Conshohocken, PA
2 days ago
Team Lead
...Team Lead The Team Lead is responsible for managing restaurant operations, in conjunction with or in the absence of the Restaurant Manager. Uses discretion in daily management decisions with accountability for living the Brand values and helping the brand thrive. Focuses...
Flexible hours
Qdoba
Conshohocken, PA
1 day ago
Curbside Express Lead
...Job Summary Curbside Express Leads are key players in in our stores' success. They make sure our Curbside Express orders are fulfilled quickly, accurately and with a smile. They also provide unparalleled guest service and support the Asst. Guest Service Team Leader...
Flexible hours
Night shift
Giant Eagle
Blue Bell, PA
5 days ago
Shift Lead
$18 per hour
...Guest Experience Lead - LEGOLAND Discovery Center Philadelphia This is what we do every day. Our 31,000+ awesome colleagues create... ...support, and motivate front-line teams to be truly guest-obsessed Manage queues and guest flow safely and efficiently during peak times...
Immediate start
Shift work
Sealife Services LLC
Plymouth Meeting, PA
5 days ago
Strategic Enterprise Partnerships Lead
...Vestwell is looking for an experienced Enterprise Relationship Manager to join their team in Scottsdale, AZ. This role is pivotal in managing strategic partnerships, ensuring revenue growth, and providing excellent support to existing clients. The ideal candidate will...
Vestwell
King of Prussia, PA
4 days ago
Culinary Lead
...A Healthier Future Starts With You! As a Culinary Lead (what we call a Kitchen Lead at Sweetgreen), you are the food quality... ...through craft, coaching, and consistency. This is not a people manager role. You wont write schedules or run performance reviews. You...
Full time
Part time
Casual work
Local area
Shift work
Early shift
sweetgreen
King of Prussia, PA
5 days ago
Construction Manager (Data Centers)
...JACOBS has an immediate opportunity for a Construction Manager to support our data center project in Corpus Christi, TX As a Data Center Construction... ...The Construction Manager's (CM) primary function is to lead the Pre-construction and construction process in reviewing...
Contract work
Temporary work
For contractors
Work experience placement
For subcontractor
Work at office
Immediate start
Jacobs
Conshohocken, PA
4 days ago
Data Scientist Manager
$139.22k - $184.46k
...discriminatory means. A Brief Overview The Data Science and Biostatistics Unit (DSBU)... ...'s Research Institute to provide data management, analysis, and consultation on methods... ...Scientist Manager. This individual will lead a team of data scientists to ensure the delivery...
Full time
Part time
For contractors
Traineeship
Shift work
Children's Hospital of Philadelphia
Philadelphia, PA
3 days ago
Culinary Lead (Sur La Table)
...Culinary Lead With over 58 stores and the largest avocational cooking program in the US, Sur La Table offers an unsurpassed selection... ...-wide standard for excellence in service, and helps build and manage a high-performing culinary team. Leadership & Team...
Work at office
Local area
Flexible hours
Night shift
Touch of Modern (CSC Generation)
King of Prussia, PA
4 days ago
Power BI & Data Analytics Lead
...by offering private mortgage insurance, reinsurance, risk management products and title insurance and settlement services to mortgage... ...mortgage insurance industry. Title : Power BI & Data Analytics Lead – Operational Reporting Location: Radnor, PA (...
Full time
Work at office
Essent Guaranty, Inc.
Radnor, PA
11 days ago
2nd Shift Lead Cashier
...possibilities quite this beautiful. GENERAL SUMMARY & SCOPE The Lead Cashier (LC) is responsible for the efficiency of guest... ...professional development and drive sales performance. * Collaborate with managers and associates throughout the store to help grow the business....
Work experience placement
Local area
Flexible hours
Shift work
Afternoon shift
Ulta Beauty
King of Prussia, PA
4 days ago
Lead Architect
$147k - $226k
...research and manufacturing facilities. We are looking for a dedicated Lead Architect to join our talented team at our office in Somerset,... ...the application of prudent judgment and implementation of risk management techniques while maintaining supervision over all health,...
For contractors
Work at office
IPS-Integrated Project Services, LLC
Blue Bell, PA
5 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Lead Data Manager. Be the first to apply!