Director, HR Business Partner

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). This HR Business Partner (Director level) is focused on driving critical initiatives such as workforce planning, employee engagement, performance management, and leadership coaching to support Madrigal’s strategic objectives. The position plays a pivotal role in building a high-performance culture by aligning HR programs with the company’s core values—Focus on Patients, Owner Mindset, Innovation, and Collaboration. Key Responsibilities Establish trusted, collaborative, and responsive relationships with leaders across the organization, understanding their strategies, priorities, and goals to shape impactful HR programs and priorities that align with Madrigal’s core values. Lead key HR initiatives, including workforce planning, talent acquisition, employee relations, employee engagement and retention, learning & development, and succession planning, with measurable outcomes in mind. Coach and develop managers to strengthen their management and leadership skills, fostering high-performing and collaborative teams. Implement and manage performance management programs that align with Madrigal’s high-performance culture, driving accountability and growth. Coach managers and partner with Employee Relations team on ER issues in alignment with Company culture and policies. Collaborate across HR functions to implement tailored HR programs that address dynamic organizational needs and priorities. Contribute to HR projects and initiatives on an as-needed basis to drive organizational and operational success. Qualifications and Skills Bachelor’s degree in human resources management (or related field) is required. Graduate degree highly preferred. 10+ years of progressive HR Business Partner experience, with expertise in organizational effectiveness, change management, learning and development, and talent management. At least 2 years supporting field commercial teams in pharma or biotechnology companies. At least 3 years of experience supporting or building HR functions within biotech or pharmaceutical organizations and a demonstrated understanding of HR operating models in small to mid-size environments. Highly organized with exceptional attention to detail, ensuring clarity, accuracy, and precision in work. Analytical mindset with the ability to interpret data, identify trends, and translate insights into actionable recommendations. Proficiency in Workday and Microsoft Office Suite (Word, Excel, PowerPoint, Outlook). Demonstrated consultative style with experience supporting employees and management at all levels. Excellent communication skills, both verbal and written, with the ability to convey complex ideas clearly and concisely. Ability to travel up to 20%. Benefits Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Base salary for this position is estimated at $203,000 - $249,000 per year. Employees receive equity and are eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings. Additional voluntary benefits include supplemental life insurance, legal services, and mental health support through an Employee Assistance Program. Equal Opportunity Employer Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran status, or other characteristics protected by applicable federal, state, or local law. #J-18808-Ljbffr